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View article: Germline and somatic mutational variants of Tunisian high grade serous ovarian cancer identified by next-generation sequencing
Germline and somatic mutational variants of Tunisian high grade serous ovarian cancer identified by next-generation sequencing Open
This study provides the first comprehensive genetic profiling of Tunisian HGSOC patients, highlighting the prevalence of pathogenic mutations in key cancer-related genes. These findings emphasize the importance of genetic screening in the …
View article: Genetic profiling of inherited colorectal cancer syndromes in Tunisian patients
Genetic profiling of inherited colorectal cancer syndromes in Tunisian patients Open
Objective Colorectal cancer (CRC) is among the most commonly diagnosed cancers worldwide, with 2% to 5% of cases being linked to inherited syndromes. Material and methods A cohort of 30 Tunisian patients was selected and divided into two g…
View article: Abdominal Actinomycosis Abscess Mimicking Malignancy: A Case Report and Review of the Literature
Abdominal Actinomycosis Abscess Mimicking Malignancy: A Case Report and Review of the Literature Open
Actinomycosis is a rare chronic granulomatous infection caused by Actinomyces species. We report the case of a 47-year-old man with no previous medical history, who presented with a slowly growing abdominal mass extending to the abdominal …
View article: Primary Ewing Sarcoma in the Sphenoidal Sinus: A Case Report
Primary Ewing Sarcoma in the Sphenoidal Sinus: A Case Report Open
Ewing’s sarcoma (EWS) is a rare malignant bone tumor that primarily affects children and young adults. While it typically affects long bones, it can occur in the head and neck region, including the paranasal sinuses in rare cases. We prese…
View article: Epidemiology of bone tumors in children and adolescents: a retrospective study of 266 patients in the south of Tunisia
Epidemiology of bone tumors in children and adolescents: a retrospective study of 266 patients in the south of Tunisia Open
Although bone tumors (BT) are relatively uncommon among the human neoplasm, they constitute the most frequent tumors in children and adolescents (CAA). Little information is available about the epidemiologic features of BT in CAA. We aimed…
View article: Assessment of histology's performance compared with PCR in the diagnosis of <i>Helicobacter pylori</i> infection
Assessment of histology's performance compared with PCR in the diagnosis of <i>Helicobacter pylori</i> infection Open
Aim: Histology is the most widely used test to detect H. pylori. PCR is less used but allows the detection of both infection and antibiotics' resistance. Methods: We conducted a monocentric cross-sectional study, collecting 97 symptomatic …
View article: Impact of the COVID-19 pandemic on breast cancer pathological stage at diagnosis in Tunisian patients
Impact of the COVID-19 pandemic on breast cancer pathological stage at diagnosis in Tunisian patients Open
BACKGROUND: Breast cancer (BC) patients’ diagnosis and management was affected by a global reorganization after the Coronavirus disease 2019 (COVID-19). Our study aimed to assess the impact of the pandemic on the pathological stage of newl…
View article: Bladder metastasis originating from gastric signet-ring cell carcinoma: a case report
Bladder metastasis originating from gastric signet-ring cell carcinoma: a case report Open
Bladder metastasis of gastric adenocarcinoma is a rare phenomenon. Hereby, we report a case of a 52-year-old patient who presented with upper gastro-intestinal bleeding and ascites and was diagnosed with gastric signet-ring cell carcinoma.…
View article: Enterobius vermicularis induced bartholin gland abscess
Enterobius vermicularis induced bartholin gland abscess Open
Bartholin gland abscesses are typically caused by bacterial agents. Abscesses induced by Enterobius vermicularis are exceptional. We report, here, the case of a 27-year-old woman, whose histopathological examination of the Bartholin gland …
View article: Anaplastic Thyroid Carcinoma Mimicking Cervical Tuberculosis: A Case Report
Anaplastic Thyroid Carcinoma Mimicking Cervical Tuberculosis: A Case Report Open
Anaplastic thyroid carcinoma is a rare and aggressive form of thyroid cancer that has a poor prognosis and a high mortality rate. It is characterized by rapid growth and invasion of nearby tissues. It typically presents as a rapidly growin…
View article: Colorectal Cancer Archaeome: A Metagenomic Exploration, Tunisia
Colorectal Cancer Archaeome: A Metagenomic Exploration, Tunisia Open
Colorectal cancer (CRC) is a serious public health problem known to have a multifactorial etiology. The association between gut microbiota and CRC has been widely studied; however, the link between archaea and CRC has not been sufficiently…
View article: Tetraploidization Increases the Motility and Invasiveness of Cancer Cells
Tetraploidization Increases the Motility and Invasiveness of Cancer Cells Open
Polyploidy and metastasis are associated with a low probability of disease-free survival in cancer patients. Polyploid cells are known to facilitate tumorigenesis. However, few data associate polyploidization with metastasis. Here, by gene…
View article: Anaplastic Thyroid Carcinoma Mimicking Cervical Tuberculosis: A Case Report
Anaplastic Thyroid Carcinoma Mimicking Cervical Tuberculosis: A Case Report Open
Introduction:Cancer and tuberculosis are two common diseases that affect health worldwide. They affect various organs and typically present with different clinical manifestations. However, these two diseases can sometimes present with unus…
View article: Warthin-like papillary thyroid carcinoma: a case report and comprehensive review of the literature
Warthin-like papillary thyroid carcinoma: a case report and comprehensive review of the literature Open
Background Papillary Thyroid Carcinoma (PTC) is the most frequent endocrine malignancy with a variety of histological presentations. Warthin-like Papillary Thyroid Carcinoma (WLPTC) is an uncommon neoplasm that is recognized as a distinct …
View article: Predominance of the Rare EGFR Mutation p.L861Q in Tunisian Patients with Non-Small Cell Lung Carcinoma
Predominance of the Rare EGFR Mutation p.L861Q in Tunisian Patients with Non-Small Cell Lung Carcinoma Open
Objectives: Several new cancer therapies targeting signaling pathways involved in the growth and progression of cancer cells were developed as personalized medicine. Our study aimed to identify epidermal growth factor receptor (EGFR) mutat…
View article: Atypical spindle cell lipomatous tumor of the tongue: A rare entity arising in an unusual location
Atypical spindle cell lipomatous tumor of the tongue: A rare entity arising in an unusual location Open
Atypical spindle cell/pleomorphic lipomatous tumor (ASCPT) constitutes an emerging entity of lipomatous tumors. It is a benign tumor. It occurs typically in limbs and limb girdles. The occurrence in oral cavity is unusual. The diagnosis of…
View article: Unusual facial lesions in H syndrome
Unusual facial lesions in H syndrome Open
H Syndrome is a rare genodermatosis. It may include facial involvement such as: facial telangiectasia, both hypo‐ and hyperpigmented lesions, hirsutism, swollen cheeks due to subcutaneous infiltration and eczematous lesions. We describe a …
View article: Fat necrosis: A neglected side effect of intramuscular injections
Fat necrosis: A neglected side effect of intramuscular injections Open
Panniculitis has various etiologies. One of the less common causes is trauma and hence traumatic fat necrosis ( FN ). These soft tissue injuries usually appear on the shins, thighs, breasts, arms, and buttocks. FN is mainly caused by traum…
View article: Great imitator with exclusive oral manifestations
Great imitator with exclusive oral manifestations Open
Oral manifestations in syphilis are frequent through the different stages of the disease. Exclusive oral localization in secondary syphilis (SS) is yet uncommon. Delays in diagnosis are frequent in these patients. We describe a case of SS …
View article: Extragenital Lichen Sclerosus
Extragenital Lichen Sclerosus Open
Introduction: Lichen sclerosus is a chronic inflammatory and atrophic dermatosis affecting preferentially the anogenital region. However, the cutaneous involvement remains less known and studied. Methods: We collected 17 patients to study …
View article: Fat necrosis: a neglected side effect of intramuscular injections.
Fat necrosis: a neglected side effect of intramuscular injections. Open
Fat necrosis (FN) is an uncommon etiology of panniculitis. It is mainly caused by trauma and may be associated to other conditions such as pancreatic disease. We report an interesting case of subcutaneous FN caused by intramuscular injecti…
View article: Multiple nodules in the scrotal wall
Multiple nodules in the scrotal wall Open
Herein, we report a rare case of extensive ISC. It affects dark‐colored skin men aged from 20 to 40 years old, suggesting an ethnic susceptibility. Pathogenesis of scrotal calcinosis remains controversial.