Serena M. Dudek
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View article: Mineralocorticoid receptor deletion alters spontaneous behavior in an automated home-cage monitoring apparatus
Mineralocorticoid receptor deletion alters spontaneous behavior in an automated home-cage monitoring apparatus Open
Mineralocorticoid receptors (MRs) are transcription factors expressed throughout the body and brain, with especially high expression in the hippocampal area CA2. MRs are essential for maintaining the physiological stress response and regul…
View article: Mineralocorticoid receptor knockout alters hippocampal CA2 neurons to become like those in CA1
Mineralocorticoid receptor knockout alters hippocampal CA2 neurons to become like those in CA1 Open
Hippocampal area CA2 has emerged as a functionally and molecularly distinct part of the hippocampus and is necessary for several types of social behavior including social aggression. As part of the unique molecular profile of both mouse an…
View article: Perineuronal Nets on CA2 Pyramidal Cells and Parvalbumin-Expressing Cells Differentially Regulate Hippocampal-Dependent Memory
Perineuronal Nets on CA2 Pyramidal Cells and Parvalbumin-Expressing Cells Differentially Regulate Hippocampal-Dependent Memory Open
Perineuronal nets (PNNs) are a specialized extracellular matrix that surrounds certain populations of neurons, including (inhibitory) parvalbumin (PV)-expressing interneurons throughout the brain and (excitatory) CA2 pyramidal neurons in h…
View article: Fate (or state) of CA2 neurons in a mineralocorticoid receptor knockout
Fate (or state) of CA2 neurons in a mineralocorticoid receptor knockout Open
Hippocampal area CA2 has emerged as a functionally and molecularly distinct part of the hippocampus and is necessary for several types of social behavior, including social aggression. As part of the unique molecular profile of both mouse a…
View article: Hippocampal CA2 neurons disproportionately express AAV-delivered genetic cargo
Hippocampal CA2 neurons disproportionately express AAV-delivered genetic cargo Open
Hippocampal area CA2 is unique in many ways, largely based on the complement of genes expressed there. We and others have observed that CA2 neurons exhibit a uniquely robust tropism for adeno-associated viruses (AAVs) of multiple serotypes…
View article: Perineuronal nets on CA2 pyramidal cells and parvalbumin-expressing cells differentially regulate hippocampal dependent memory
Perineuronal nets on CA2 pyramidal cells and parvalbumin-expressing cells differentially regulate hippocampal dependent memory Open
Perineuronal nets (PNNs) are a specialized extracellular matrix that surround certain populations of neurons, including (inhibitory) parvalbumin (PV) expressing-interneurons throughout the brain and (excitatory) CA2 pyramidal neurons in hi…
View article: Prenatal exposure to the mineralocorticoid receptor antagonist spironolactone disrupts hippocampal area CA2 connectivity and alters behavior in mice
Prenatal exposure to the mineralocorticoid receptor antagonist spironolactone disrupts hippocampal area CA2 connectivity and alters behavior in mice Open
In the brain, the hippocampus is enriched with mineralocorticoid receptors (MR; Nr3c2 ), a ligand-dependent transcription factor stimulated by the stress hormone corticosterone in rodents. Recently, we discovered that MR is required for th…
View article: Characterization of spironolactone and metabolites derivatized using Girard's reagent P using mass spectrometry and ion mobility spectrometry
Characterization of spironolactone and metabolites derivatized using Girard's reagent P using mass spectrometry and ion mobility spectrometry Open
Rationale Spironolactone is a steroidal drug prescribed for a variety of medical conditions and is extensively metabolized quickly after administration. Measurement of spironolactone and its metabolites remains challenging using mass spect…
View article: Identification of hippocampal area CA2 in hamster and vole brain
Identification of hippocampal area CA2 in hamster and vole brain Open
Prairie voles ( Microtus ochrogaster ) and Syrian, or golden, hamsters ( Mesocricetus auratus ) are closely related to mice ( Mus musculus ) and are commonly used in studies of social behavior including social interaction, social memory, a…
View article: Hippocampal area CA2 activity supports social investigation following an acute social stress
Hippocampal area CA2 activity supports social investigation following an acute social stress Open
Neuronal activity in the hippocampus is critical for many types of memory acquisition and retrieval and influences an animal’s response to stress. Moreover, the molecularly distinct principal neurons of hippocampal area CA2 are required fo…
View article: Identification of hippocampal area CA2 in hamster and vole brain
Identification of hippocampal area CA2 in hamster and vole brain Open
Prairie voles ( Microtus ochrogaster ) and Syrian, or golden, hamsters ( Mesocricetus auratus ) are closely related to mice ( Mus musculus ) and rats ( Rattus norvegicus , for example) and are commonly used in studies of social behavior in…
View article: Defining hippocampal area <scp>CA2</scp> in the fox (<scp><i>Vulpes vulpes</i></scp>) brain
Defining hippocampal area <span>CA2</span> in the fox (<span><i>Vulpes vulpes</i></span>) brain Open
Since 1959, the Russian Farm‐Fox study has bred foxes to be either tame or, more recently, aggressive, and scientists have used them to gain insight into the brain structures associated with these behavioral features. In mice, hippocampal …
View article: Mechanisms of <scp>mGluR</scp>‐dependent plasticity in hippocampal area <scp>CA2</scp>
Mechanisms of <span>mGluR</span>‐dependent plasticity in hippocampal area <span>CA2</span> Open
Pyramidal cells in hippocampal area CA2 have synaptic properties that are distinct from the other CA subregions. Notably, this includes a lack of typical long‐term potentiation of stratum radiatum synapses. CA2 neurons express high levels …
View article: Cover Image, Volume 33, Issue 3
Cover Image, Volume 33, Issue 3 Open
The cover image is based on the Editorial Introduction to the special issue on: A new view of hippocampal area CA2, by Serena M. Dudek, Georgia M. Alexander, and Shannon Farris Published online in Wiley Online Library, https://doi.org/10.1…
View article: Morphological and molecular markers of mouse area<scp>CA2</scp>along the proximodistal and dorsoventral hippocampal axes
Morphological and molecular markers of mouse area<span>CA2</span>along the proximodistal and dorsoventral hippocampal axes Open
Hippocampal area CA2 is a molecularly and functionally distinct region of the hippocampus that has classically been defined as the area with large pyramidal neurons lacking input from the dentate gyrus and the thorny excrescences (TEs) cha…
View article: Perineuronal net degradation rescues CA2 plasticity in a mouse model of Rett syndrome
Perineuronal net degradation rescues CA2 plasticity in a mouse model of Rett syndrome Open
Perineuronal nets (PNNs), a specialized form of extracellular matrix, are abnormal in the brains of people with Rett syndrome (RTT). We previously reported that PNNs function to restrict synaptic plasticity in hippocampal area CA2, which i…
View article: Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5
Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5 Open
Responding to different dynamic levels of stress is critical for mammalian survival. Disruption of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) signaling is proposed to underlie hypothalamic-pituitary-adrenal (HPA) axis…
View article: Distinct and dementia‐related synaptopathy in the hippocampus after military blast exposures
Distinct and dementia‐related synaptopathy in the hippocampus after military blast exposures Open
Explosive shockwaves, and other types of blast exposures, are linked to injuries commonly associated with military service and to an increased risk for the onset of dementia. Neurological complications following a blast injury, including d…
View article: Modified adeno‐associated virus targets the bacterial enzyme chondroitinase ABC to select mouse neuronal populations in vivo using the Cre‐LoxP system
Modified adeno‐associated virus targets the bacterial enzyme chondroitinase ABC to select mouse neuronal populations in vivo using the Cre‐LoxP system Open
Current methods of experimentally degrading the specialized extracellular matrix (ECM), perineuronal nets (PNNs) have several limitations. Genetic knockout of ECM components typically has only partial effects on PNNs, and knockout of the m…
View article: Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice
Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice Open
Obsessive-compulsive disorder (OCD) is an anxiety-spectrum disorder characterized by persistent intrusive thoughts (obsessions) and repetitive actions (compulsions). Dysfunction of cortico-striato-thalamo-cortical circuitry is implicated i…
View article: Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons
Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons Open
The human genome contains vast genetic diversity as naturally occurring coding variants, yet the impact of these variants on protein function and physiology is poorly understood. RGS14 is a multifunctional signaling protein that suppresses…
View article: Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons
Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons Open
The human genome contains vast genetic diversity in the form of naturally occurring coding variants, yet the impact of these variants on protein function and physiology is poorly understood. RGS14 is a multifunctional signaling protein tha…
View article: Adenosine A1 Receptor-Mediated Synaptic Depression in the Developing Hippocampal Area CA2
Adenosine A1 Receptor-Mediated Synaptic Depression in the Developing Hippocampal Area CA2 Open
Immunolabeling for adenosine A1 receptors (A1Rs) is high in hippocampal area CA2 in adult rats, and the potentiating effects of caffeine or other A1R-selective antagonists on synaptic responses are particularly robust at Schaffer collatera…
View article: Hippocampal Interneuronal α7 nAChRs Modulate Theta Oscillations in Freely Moving Mice
Hippocampal Interneuronal α7 nAChRs Modulate Theta Oscillations in Freely Moving Mice Open
Muscarinic acetylcholine receptors (mAChRs) are critically involved in hippocampal theta generation, but much less is known about the role of nicotinic AChRs (nAChRs). Here we provide evidence that α7 nAChRs expressed on interneurons, part…
View article: Perineuronal Nets Suppress Plasticity of Excitatory Synapses on CA2 Pyramidal Neurons
Perineuronal Nets Suppress Plasticity of Excitatory Synapses on CA2 Pyramidal Neurons Open
Long-term potentiation of excitatory synapses on pyramidal neurons in the stratum radiatum rarely occurs in hippocampal area CA2. Here, we present evidence that perineuronal nets (PNNs), a specialized extracellular matrix typically localiz…
View article: Recombinase-Dependent Mouse Lines for Chemogenetic Activation of Genetically Defined Cell Types
Recombinase-Dependent Mouse Lines for Chemogenetic Activation of Genetically Defined Cell Types Open
Chemogenetic technologies, including the mutated human Gq-coupled M3 muscarinic receptor (hM3Dq), have greatly facilitated our ability to directly link changes in cellular activity to altered physiology and behavior. Here, we extend the hM…
View article: Hippocampal CA2 Organizes CA1 Slow and Fast γ Oscillations during Novel Social and Object Interaction
Hippocampal CA2 Organizes CA1 Slow and Fast γ Oscillations during Novel Social and Object Interaction Open
A key goal in hippocampal research is to understand how neuronal activity is generated and organized across hippocampal subregions to enable memory formation and retrieval. Neuronal activity in CA2 is regulated by spatial and social invest…