Saleh Ibrahim
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View article: Evolving Therapeutic Paradigms in Bladder Cancer: the Impact of Immunotherapy and Antibody-Drug Conjugates
Evolving Therapeutic Paradigms in Bladder Cancer: the Impact of Immunotherapy and Antibody-Drug Conjugates Open
Bladder cancer is a significant global health challenge. Despite advances in surgery and platinum-based chemotherapy over the decades, limited improvements in clinical outcomes have been observed. However, recent years have witnessed the d…
View article: The Emirati T2T-Level Pangenome: A Graph of 58 Complete Genomes
The Emirati T2T-Level Pangenome: A Graph of 58 Complete Genomes Open
Reference data on genomic variation form the basis of genetic research. Limitations in identifying genetic variation from single reference sequences have been recently overcome, as improvements in sequencing technologies have allowed the g…
View article: Gut Microbiota Modulates and Predicts Disease Severity in Experimental Pemphigoid Disease
Gut Microbiota Modulates and Predicts Disease Severity in Experimental Pemphigoid Disease Open
Pemphigoid diseases (PD) are autoimmune blistering diseases with reported alterations in skin and gut microbiota, though their causal contribution to disease pathophysiology remains unclear. Using a passive model of bullous pemphigoid-like…
View article: Proteo-transcriptomic reprogramming and resource reallocation define the aging mammalian brain
Proteo-transcriptomic reprogramming and resource reallocation define the aging mammalian brain Open
Brain aging is a major risk for neurodegeneration, yet the underlying molecular mechanisms remain poorly understood. Here we performed an integrative proteo-transcriptomic analysis of the aging mouse brain, uncovering molecular signatures …
View article: Lipid nanoparticle delivery of the CRISPR/Cas9 system directly into the mitochondria of cells carrying m.7778G>T mutation in MtDNA (mt-Atp8)
Lipid nanoparticle delivery of the CRISPR/Cas9 system directly into the mitochondria of cells carrying m.7778G>T mutation in MtDNA (mt-Atp8) Open
Mitochondrial genome mutations are associated with various diseases and gene therapy targeted to mitochondria has the potential to effectively treat such diseases. Here, we targeted a point mutation in mitochondrial DNA (mtDNA) that can ca…
View article: An effective approach to modulate mitochondrial function in murine primary macrophages by a mitochondria-targeted nanocapsule, MITO-Porter
An effective approach to modulate mitochondrial function in murine primary macrophages by a mitochondria-targeted nanocapsule, MITO-Porter Open
Macrophages play crucial roles in various pathological conditions as well as maintenance of homeostasis. Many chronic inflammatory conditions, such as atherosclerosis, rheumatoid arthritis, and obesity, are known to involve the polarizatio…
View article: Maternal Serum Ferritin Concentration in Patient with Preterm Labor and Intact Membranes
Maternal Serum Ferritin Concentration in Patient with Preterm Labor and Intact Membranes Open
Background: Preterm labor poses significant obstetric challenges due to its multifactorial etiology and associated neonatal risks. Accurate prediction is essential for timely medical interventions, which can improve maternal and neonatal o…
View article: Seroprevalence of Feline Toxoplasmosis in Kuwait State
Seroprevalence of Feline Toxoplasmosis in Kuwait State Open
This study is conducted in Animal House Veterinary Hospital Laboratory in Kuwait stat. Therefore, the aim of the current study is to assess the seroprevalence of toxoplasmosis in cats. A total of 120 samples were taken randomly from the ca…
View article: DOP030 Mucosal deficiency of mitochondria-driven humoral immunity is linked to Crohn’s Disease
DOP030 Mucosal deficiency of mitochondria-driven humoral immunity is linked to Crohn’s Disease Open
Background Secretory IgA (sIgA) is critical for the maintenance of the mucosal barrier function, preventing bacterial translocation and reducing the risk of chronic inflammation. Several decades of research have revealed a dysregulation of…
View article: Characterization of the Gut and Skin Microbiome over Time in Young Children with IgE-Mediated Food Allergy
Characterization of the Gut and Skin Microbiome over Time in Young Children with IgE-Mediated Food Allergy Open
Background/Objectives: The prevalence of food allergy (FA) in children is increasing. Dysbiosis of the microbiome has been linked to FA but needs to be better understood. We aimed to characterize the gut and skin microbiome of young food-a…
View article: Beyond one size fits all: Probing patient choices in gestational diabetes management, from screening to postpartum
Beyond one size fits all: Probing patient choices in gestational diabetes management, from screening to postpartum Open
During antenatal care, gestational diabetes mellitus (GDM) screening is crucial for early diagnosis and treatment to ameliorate clinical outcomes and limit health care expenses. Dietary management and physical activity are central to GDM t…
View article: Modulation of Plet1 Expression by N-Acetylglucosamine through the IL-17A- MAPK Pathway in an Imiquimod-Induced Psoriasis Mouse Model
Modulation of Plet1 Expression by N-Acetylglucosamine through the IL-17A- MAPK Pathway in an Imiquimod-Induced Psoriasis Mouse Model Open
Psoriasis (Ps) is a chronic inflammatory disorder marked by skin plaque formation, driven by immune dysregulation and genetic factors. Despite the available treatments, the incidence of Ps is increasing in the dermatology patients. Novel s…
View article: Tingkat Pengetahuan dan Persepsi Masyarakat Tentang Vaksin Covid-19 di Kecamatan yang berada di Kabupaten Gorontalo
Tingkat Pengetahuan dan Persepsi Masyarakat Tentang Vaksin Covid-19 di Kecamatan yang berada di Kabupaten Gorontalo Open
Vaccination is aimed at preventing the spread of COVID-19. In this case, the lack of knowledge and negative perceptions are included in the factors that cause people to be afraid to get vaccinated. The purpose of this study was to determin…
View article: Mitochondrial DNA variants and microbiota: An experimental strategy to identify novel therapeutic potential in chronic inflammatory diseases
Mitochondrial DNA variants and microbiota: An experimental strategy to identify novel therapeutic potential in chronic inflammatory diseases Open
We previously demonstrated that mice carrying natural mtDNA variants of the FVB/NJ strain (m.7778 G>T in the mt-Atp8 gene in mitochondrial complex V), namely C57BL/6 J-mtFVB/NJ (B6-mtFVB), exhibited (i) partial protection from experimental…
View article: Precision Nutrition Unveiled: Gene–Nutrient Interactions, Microbiota Dynamics, and Lifestyle Factors in Obesity Management
Precision Nutrition Unveiled: Gene–Nutrient Interactions, Microbiota Dynamics, and Lifestyle Factors in Obesity Management Open
Background: Obesity is a complex metabolic disorder that is associated with several diseases. Recently, precision nutrition (PN) has emerged as a tailored approach to provide individualised dietary recommendations. Aim: This review discuss…
View article: Mitochondrial somatic mutation and selection throughout ageing
Mitochondrial somatic mutation and selection throughout ageing Open
Mitochondrial genomes co-evolve with the nuclear genome over evolutionary timescales and are shaped by selection in the female germline. Here we investigate how mismatching between nuclear and mitochondrial ancestry impacts the somatic evo…
View article: 1H-NMR metabolomics analysis identifies hypoxanthine as a novel metastasis-associated metabolite in breast cancer
1H-NMR metabolomics analysis identifies hypoxanthine as a novel metastasis-associated metabolite in breast cancer Open
Breast cancer is one of the leading causes of death in females, mainly because of metastasis. Oncometabolites, produced via metabolic reprogramming, can influence metastatic signaling cascades. Accordingly, and based on our previous result…
View article: Unraveling the gut-Lung axis: Exploring complex mechanisms in disease interplay
Unraveling the gut-Lung axis: Exploring complex mechanisms in disease interplay Open
The link between gut and lung starts as early as during organogenesis. Even though they are anatomically distinct, essential bidirectional crosstalk via complex mechanisms supports GLA. Emerging studies have demonstrated the association of…
View article: Genetic Association and Differential RNA Expression of Histone (De)Acetylation-Related Genes in Pemphigus Foliaceus—A Possible Epigenetic Effect in the Autoimmune Response
Genetic Association and Differential RNA Expression of Histone (De)Acetylation-Related Genes in Pemphigus Foliaceus—A Possible Epigenetic Effect in the Autoimmune Response Open
Pemphigus foliaceus (PF) is an autoimmune skin blistering disease characterized by antidesmoglein-1 IgG production, with an endemic form (EPF) in Brazil. Genetic and epigenetic factors have been associated with EPF, but its etiology is sti…
View article: The gut microbiome in bullous pemphigoid: implications of the gut-skin axis for disease susceptibility
The gut microbiome in bullous pemphigoid: implications of the gut-skin axis for disease susceptibility Open
Bullous pemphigoid (BP) is an autoimmune blistering disease that primarily affects the elderly. An altered skin microbiota in BP was recently revealed. Accumulating evidence points toward a link between the gut microbiota and skin diseases…
View article: A comprehensive analysis of gut and skin microbiota in canine atopic dermatitis in Shiba Inu dogs
A comprehensive analysis of gut and skin microbiota in canine atopic dermatitis in Shiba Inu dogs Open
Background Like its human counterpart, canine atopic dermatitis (cAD) is a chronic relapsing condition; thus, most cAD-affected dogs will require lifelong treatment to maintain an acceptable quality of life. A potential intervention is mod…
View article: A life for autoimmune blistering diseases: in memoriam Detlef Zillikens
A life for autoimmune blistering diseases: in memoriam Detlef Zillikens Open
Detlef Zillikens, MD, director and chair of the Department of Dermatology at the University of Lübeck, Lübeck, Germany, died in September 2022, aged only 64. He dedicated his professional life to autoimmune blistering diseases (AIBDs) and …
View article: Mining medicine prescriptions to enhance predictive management of COVID-19 patients in the UAE
Mining medicine prescriptions to enhance predictive management of COVID-19 patients in the UAE Open
Data mining is becoming more popular in the healthcare industry to enhance decision-making and patient outcomes. In this study, we examined medication patterns in over 10,000 COVID-19 patients spanning over three years from the UAE. Prescr…