Explanipedia

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A. Heufelder, M. Pugeat, S Shalet, A. Leal Cerro, M.L. Vance , et al. · 2004

The Relationship between 24-Hour Growth Hormone Secretion and Insulin-Like Growth Factor I in Patients with Successfully Treated Acromegaly: Impact of Surgery or Radiotherapy Open

Steven R. Peacey, Andrew Toogood, Johannes D. Veldhuis, Michael O. Thorner, S Shalet · 2001

In patients with treated acromegaly, improved survival is associated with serum GH concentrations below 2 microgram/L (5 mU/L). A principal aim of therapy in acromegaly is to achieve a GH level less than 2 microgram/L, as such levels are t…

Influences on quality of life in GH deficient adults and their effect on response to treatment Open

Robert Murray, C. J. Skillicorn, Sacha J. Howell, Catherine A. Lissett, A. Rahim , et al. · 1999

OBJECTIVE Studies of the effect of GH on quality of life (QOL) in growth hormone deficient (GHD) adults have reported conflicting results. Recently, however, we have demonstrated that by selecting only those patients with impaired QOL the …

Gonadotrophin-releasing hormone analogues: a novel treatment for premenstrual asthma Open

R.Daniel Murray, John P. New, P.V. Barber, S Shalet · 1999

Premenstrual exacerbation of asthma, as reflected by a reduction in peak expiratory flow rate (PEFR), has been demonstrated in 40-100% of female asthmatics. Epidemiological data demonstrate that admission to hospital with an exacerbation o…

Leptin Binding Activity Changes with Age: The Link between Leptin and Puberty1 Open

Naomi Quinton, Robert F. Smith, Peter Clayton, Matthew S. Gill, S Shalet , et al. · 1999

The timing of the physical transition from child to adult is determined by a biological clock that switches off the pituitary gonadal axis during infancy until puberty. Body composition (and in particular, fat mass), through leptin, are cr…

Thyroid hormone actions on cartilage and bone: interactions with other hormones at the epiphyseal plate and effects on linear growth Open

G. R. Williams, Helen Robson, S Shalet · 1998

Normal linear growth is determined by variable contributions from genetic, nutritional and endocrine factors and continues until bone maturation and epiphyseal closure in early adulthood. The major systemic hormones that influence growth d…

Neurosurgery in a patient with Creutzfeldt-Jakob disease after pituitary derived growth hormone therapy in childhood. Open

Sarah J. Holmes, James W. Ironside, S Shalet · 1996

The case of a young man who had previously received pituitary derived growth hormone for treatment of radiation induced growth hormone deficiency is reported. He underwent neurosurgery for presumed recurrence of a posterior fossa tumour bu…

Disproportionate short stature after cranial irradiation and combination chemotherapy for leukaemia. Open

Helena Davies, E Didcock, Mo Didi, Amanda Ogilvy‐Stuart, J K Wales , et al. · 1994

The effect of combination chemotherapy and cranial irradiation on final height and body proportions was retrospectively examined in a cohort of 142 children treated for acute lymphoblastic leukaemia (ALL). Eighty four children (48 girls, 3…

FINAL HEIGHT AND DISPROPORTION AFFER CRANIAL RADIOTHERAPY FOR LEUKAEMIA Open

Helena Davies, Mohammed Didi, E Didcock, A L Ogilvy-Siuan, S Shalet , et al. · 1993

ENDOCRINE OUTCOME Open

S Shalet · 1993

WEIGHT GAIN FOLLOWING PROLONGED REMISSION IN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKAEMIA Open

Mo Didi, E Didcock, Helena Davies, Amanda Ogilvy‐Stuart, J K Wales , et al. · 1993

Does growth hormone treatment improve final height attainment of children with intrauterine growth retardation? Open

S Shalet · 1992

The evolution of spinal growth after irradiation Open

Peter Clayton, S Shalet · 1991

Ovarian function following chemotherapy for childhood brain tumours Open

Peter Clayton, S Shalet, David A. Price, P H Morris Jones · 1989

Pubertal development, basal gonadotrophin, and oestradiol levels were assessed in 21 girls who had received neuroaxis irradiation for a brain tumour followed by adjuvant chemotherapy with carmustine (BCNU) or lomustine (CCNU) and procarbaz…

Clinics in Endocrinology and Metabolism Open

S Shalet · 1978

Ovarian failure following abdominal irradiation in childhood Open

S Shalet, C G Beardwell, P H Morris Jones, D Pearson, D. H. Orrell · 1976

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