Smijin Soman
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View article: The Mitochondrial Foundations of Parkinson’s Disease: Therapeutic Implications
The Mitochondrial Foundations of Parkinson’s Disease: Therapeutic Implications Open
Mitochondria are dynamic organelles vital for neuronal function due to their ability to generate ATP, sequester cytosolic calcium (Ca2+), regulate lipid metabolism, and modulate apoptosis signaling. In order to maintain these essential fun…
View article: <scp>Brain‐derived</scp> neurotrophic factor protects neurons by stimulating mitochondrial function through protein kinase A
<span>Brain‐derived</span> neurotrophic factor protects neurons by stimulating mitochondrial function through protein kinase A Open
Brain‐derived neurotrophic factor (BDNF) stimulates dendrite outgrowth and synaptic plasticity by activating downstream protein kinase A (PKA) signaling. Recently, BDNF has been shown to modulate mitochondrial respiration in isolated brain…
View article: Editorial: Altered bioenergetics, mitochondrial quality control, and calcium signaling in the brain: Implications to age-related diseases
Editorial: Altered bioenergetics, mitochondrial quality control, and calcium signaling in the brain: Implications to age-related diseases Open
EDITORIAL article Front. Aging, 01 March 2023Sec. Aging, Metabolism and Redox Biology Volume 4 - 2023 | https://doi.org/10.3389/fragi.2023.1171221
View article: Role of Cleaved PINK1 in Neuronal Development, Synaptogenesis, and Plasticity: Implications for Parkinson’s Disease
Role of Cleaved PINK1 in Neuronal Development, Synaptogenesis, and Plasticity: Implications for Parkinson’s Disease Open
Mitochondrial dysfunction plays a significant role in the pathogenesis of Parkinson’s disease (PD). Consistent with this concept, loss of function mutations in the serine/threonine kinase- PINK1 (PTEN-induced putative kinase-1) causes auto…
View article: Cleaved PINK1 induces neuronal plasticity through PKA‐mediated BDNF functional regulation
Cleaved PINK1 induces neuronal plasticity through PKA‐mediated BDNF functional regulation Open
Mutations in PTEN‐induced kinase 1 (PINK1) lead to early onset autosomal recessive Parkinson's disease in humans. In healthy neurons, full‐length PINK1 (fPINK1) is post‐translationally cleaved into different lower molecular weight forms, a…
View article: Restriction of mitochondrial calcium overload by <i>mcu</i> inactivation renders neuroprotective effect in Zebrafish models of Parkinson's disease
Restriction of mitochondrial calcium overload by <i>mcu</i> inactivation renders neuroprotective effect in Zebrafish models of Parkinson's disease Open
The loss of dopaminergic neurons (DA) is a pathological hallmark of sporadic and familial forms of Parkinson's Disease (PD). We had previously shown that inhibiting mitochondrial calcium uniporter (mcu) using morpholinos can rescue DA neur…
View article: Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons in <i>pink1</i><sup><i>−</i>/<i>−</i></sup> zebrafish
Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons in <i>pink1</i><sup><i>−</i>/<i>−</i></sup> zebrafish Open
Mutations in PTEN ‐induced putative kinase 1 ( PINK 1 ) are a cause of early onset Parkinson's disease ( PD ). Loss of PINK 1 function causes dysregulation of mitochondrial calcium homeostasis, resulting in mitochondrial dysfunction and ne…