Smitha Jayakumar
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View article: RNA Polymerase Pausing Complex Promotes CD8+ T Cell Response in the Tumor Microenvironment 9355
RNA Polymerase Pausing Complex Promotes CD8+ T Cell Response in the Tumor Microenvironment 9355 Open
Description Tumor immunity is influenced by CD8+ T cell responses, which have significant implications for hospitalization, treatment costs, and patient outcomes. However, the molecular mechanisms that control CD8+ T cell activity in the t…
View article: The β-catenin C terminus links Wnt and sphingosine-1-phosphate signaling pathways to promote vascular remodeling and atherosclerosis
The β-catenin C terminus links Wnt and sphingosine-1-phosphate signaling pathways to promote vascular remodeling and atherosclerosis Open
Canonical Wnt and sphingosine-1-phosphate (S1P) signaling pathways are highly conserved systems that contribute to normal vertebrate development, with key consequences for immune, nervous, and cardiovascular system function; despite these …
View article: PLX3397, a CSF1 receptor inhibitor, limits allotransplantation-induced vascular remodelling
PLX3397, a CSF1 receptor inhibitor, limits allotransplantation-induced vascular remodelling Open
Aims Graft vascular disease (GVD), a clinically important and highly complex vascular occlusive disease, arises from the interplay of multiple cellular and molecular pathways. While occlusive intimal lesions are composed predominantly of s…
View article: Allograft inflammatory factor-1-like is not essential for age dependent weight gain or HFD-induced obesity and glucose insensitivity
Allograft inflammatory factor-1-like is not essential for age dependent weight gain or HFD-induced obesity and glucose insensitivity Open
The allograft inflammatory factor (AIF) gene family consists of two identified paralogs – AIF1 and AIF1-like ( AIF1L ). The encoded proteins, AIF1 and AIF1L, are 80% similar in sequence and show conserved tertiary structure. While studies …
View article: Inhibition of Smooth Muscle β-Catenin Hinders Neointima Formation After Vascular Injury
Inhibition of Smooth Muscle β-Catenin Hinders Neointima Formation After Vascular Injury Open
Objective— Smooth muscle cells (SMCs) contribute to neointima formation after vascular injury. Although β-catenin expression is induced after injury, whether its function is essential in SMCs for neointimal growth is unknown. Moreover, alt…