Smriti Mehra
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View article: Distinct clinical outcomes in pediatric tuberculosis: a study utilizing infant macaques exposed to low and high doses of aerosol mycobacterium tuberculosis 2367
Distinct clinical outcomes in pediatric tuberculosis: a study utilizing infant macaques exposed to low and high doses of aerosol mycobacterium tuberculosis 2367 Open
Description Clinically relevant pediatric animal models are required to advance research and therapies for Mycobacterium tuberculosis (Mtb) infections in children. Utilizing infant rhesus macaques exposed to controlled doses of aerosolized…
View article: Development and preclinical evaluation of next-generation ΔsigH-based live candidate vaccines
Development and preclinical evaluation of next-generation ΔsigH-based live candidate vaccines Open
To radically diminish tuberculosis (TB) incidence and mortality by 2035, as set out by the WHO End TB Strategy, there is a desperate need for improved TB therapies and a more effective vaccine against the deadly pathogen Mycobacterium tube…
View article: Increased vaccine efficacy against tuberculosis with a recombinant BCG overexpressing the STING agonist cyclic di-AMP.
Increased vaccine efficacy against tuberculosis with a recombinant BCG overexpressing the STING agonist cyclic di-AMP. Open
Tuberculosis (TB) remains the leading cause of death due to infection globally. Bacillus Calmette Guérin (BCG), a live attenuated bacterial strain, is the only available TB vaccine, but it has poor efficacy in preventing pulmonary TB in ad…
View article: Using Imaris to rigorously track PET-defined sites of lung inflammation in <i>Mycobacterium tuberculosis</i>-exposed non-human primates
Using Imaris to rigorously track PET-defined sites of lung inflammation in <i>Mycobacterium tuberculosis</i>-exposed non-human primates Open
Aerosol exposure of non-human primates ( NHPs ) to Mycobacterium tuberculosis ( Mtb ) typically results in discrete sites of inflammation of the lung that is detectable by 2-deoxy-2-[fluorine-18]fluoro-D-glucose ( 18 F- FDG )-based PET/CT …
View article: Indoleamine-2,3-dioxygenase inhibition improves immunity and is safe for concurrent use with cART during Mtb/SIV coinfection
Indoleamine-2,3-dioxygenase inhibition improves immunity and is safe for concurrent use with cART during Mtb/SIV coinfection Open
Chronic immune activation promotes tuberculosis (TB) reactivation in the macaque Mycobacterium tuberculosis (M. tuberculosis)/SIV coinfection model. Initiating combinatorial antiretroviral therapy (cART) early lowers the risk of TB reactiv…
View article: Prevention of TB in nonhuman primates by a stress-response deficient mutant of Mycobacterium tuberculosis via induction of classical T cell immunity
Prevention of TB in nonhuman primates by a stress-response deficient mutant of Mycobacterium tuberculosis via induction of classical T cell immunity Open
The need for novel vaccination strategies to control tuberculosis (TB) is underscored by the limited and variable efficacy of the currently licensed vaccine, Bacillar Calmette-Guerin (BCG). SigH is critical for Mycobacterium tuberculosis (…
View article: Immune Responses in Lung Granulomas during Mtb/HIV Co-Infection: Implications for Pathogenesis and Therapy
Immune Responses in Lung Granulomas during Mtb/HIV Co-Infection: Implications for Pathogenesis and Therapy Open
HIV and TB are the cause of significant worldwide mortality and pose a grave danger to the global public health. TB is the leading cause of death in HIV-infected persons, with one in four deaths attributable to TB. While the majority of he…
View article: Inhibition of indoleamine dioxygenase leads to better control of tuberculosis adjunctive to chemotherapy
Inhibition of indoleamine dioxygenase leads to better control of tuberculosis adjunctive to chemotherapy Open
The expression of indoleamine 2,3-dioxygenase (IDO), a robust immunosuppressant, is significantly induced in macaque tuberculosis (TB) granulomas, where it is expressed on IFN-responsive macrophages and myeloid-derived suppressor cells. ID…
View article: Impact of SIV infection on mycobacterial lipid-reactive T cell responses in Bacillus Calmette-Guérin (BCG) inoculated macaques
Impact of SIV infection on mycobacterial lipid-reactive T cell responses in Bacillus Calmette-Guérin (BCG) inoculated macaques Open
Background Although BCG vaccine protects infants from tuberculosis (TB), it has limited efficacy in adults against pulmonary TB. Further, HIV coinfection significantly increases the risk of developing active TB. In the lack of defined corr…
View article: Early treatment with anti-α4β7 antibody facilitates increased gut macrophage maturity in SIV-infected rhesus macaques
Early treatment with anti-α4β7 antibody facilitates increased gut macrophage maturity in SIV-infected rhesus macaques Open
Despite advances in combination antiretroviral therapy (cART), people living with HIV (PLWH) continue to experience gastrointestinal dysfunction. Infusions of anti-α 4 β 7 monoclonal antibodies (mAbs) have been proposed to increase virolog…
View article: System-wide identification of myeloid markers of TB disease and HIV-induced reactivation in the macaque model of Mtb infection and Mtb/SIV co-infection
System-wide identification of myeloid markers of TB disease and HIV-induced reactivation in the macaque model of Mtb infection and Mtb/SIV co-infection Open
Mycobacterium tuberculosis ( Mtb ) has developed specialized mechanisms to parasitize its host cell, the macrophage. These mechanisms allow it to overcome killing by oxidative burst and persist in the wake of an inflammatory response. Mtb …
View article: Isoniazid and rifapentine treatment effectively reduces persistent M. tuberculosis infection in macaque lungs
Isoniazid and rifapentine treatment effectively reduces persistent M. tuberculosis infection in macaque lungs Open
A once-weekly oral dose of isoniazid and rifapentine for 3 months (3HP) is recommended by the CDC for treatment of latent tuberculosis infection (LTBI). The aim of this study is to assess 3HP-mediated clearance of M. tuberculosis bacteria …
View article: Peripheral Blood Markers Correlate with the Progression of Active Tuberculosis Relative to Latent Control of Mycobacterium tuberculosis Infection in Macaques
Peripheral Blood Markers Correlate with the Progression of Active Tuberculosis Relative to Latent Control of Mycobacterium tuberculosis Infection in Macaques Open
Despite a century of research into tuberculosis (TB), there is a dearth of reproducible, easily quantifiable, biomarkers that can predict disease onset and differentiate between host disease states. Due to the challenges associated with hu…
View article: Response to Hypoxia and the Ensuing Dysregulation of Inflammation Impacts<i>Mycobacterium tuberculosis</i>Pathogenicity
Response to Hypoxia and the Ensuing Dysregulation of Inflammation Impacts<i>Mycobacterium tuberculosis</i>Pathogenicity Open
Rationale: Different Mycobacterium tuberculosis (Mtb) strains exhibit variable degrees of virulence in humans and animal models. Differing stress response strategies used by different strains of Mtb could influence virulence. Objectives: W…
View article: The immunoregulatory landscape of human tuberculosis granulomas
The immunoregulatory landscape of human tuberculosis granulomas Open
Tuberculosis (TB) in humans is characterized by formation of immune-rich granulomas in infected tissues, the architecture and composition of which are thought to affect disease outcome. However, our understanding of the spatial relationshi…
View article: Antiretroviral therapy timing impacts latent tuberculosis infection reactivation in a Mycobacterium tuberculosis/SIV coinfection model
Antiretroviral therapy timing impacts latent tuberculosis infection reactivation in a Mycobacterium tuberculosis/SIV coinfection model Open
Studies using the nonhuman primate model of Mycobacterium tuberculosis/simian immunodeficiency virus coinfection have revealed protective CD4+ T cell-independent immune responses that suppress latent tuberculosis infection (LTBI) reactivat…
View article: Robust IgM responses following intravenous vaccination with Bacille Calmette–Guérin associate with prevention of Mycobacterium tuberculosis infection in macaques
Robust IgM responses following intravenous vaccination with Bacille Calmette–Guérin associate with prevention of Mycobacterium tuberculosis infection in macaques Open
Development of an effective tuberculosis (TB) vaccine has suffered from an incomplete understanding of the correlates of protection against Mycobacterium tuberculosis ( Mtb ). Intravenous (i.v.) vaccination with Bacille Calmette–Guérin (BC…
View article: Transcriptional Response of Mycobacterium tuberculosis to Cigarette Smoke Condensate
Transcriptional Response of Mycobacterium tuberculosis to Cigarette Smoke Condensate Open
Smoking is known to be an added risk factor for tuberculosis (TB), with nearly a quarter of the TB cases attributed to cigarette smokers in the 22 countries with the highest TB burden. Many studies have indicated a link between risk of act…
View article: Myeloid cell interferon responses correlate with clearance of SARS-CoV-2
Myeloid cell interferon responses correlate with clearance of SARS-CoV-2 Open
The emergence of mutant SARS-CoV-2 strains associated with an increased risk of COVID-19-related death necessitates better understanding of the early viral dynamics, host responses and immunopathology. While studies have reported immune pr…
View article: Myeloid cell interferon responses correlate with clearance of SARS-CoV-2
Myeloid cell interferon responses correlate with clearance of SARS-CoV-2 Open
The emergence of mutant SARS-CoV-2 strains associated with an increased risk of COVID-19-related death necessitates better understanding of the early viral dynamics, host responses and immunopathology. While studies have reported immune pr…
View article: Robust IgM responses following vaccination are associated with prevention of Mycobacterium tuberculosis infection in macaques
Robust IgM responses following vaccination are associated with prevention of Mycobacterium tuberculosis infection in macaques Open
Development of an effective tuberculosis (TB) vaccine has suffered from an incomplete understanding of the correlates of protection against Mycobacterium tuberculosis ( Mtb ). However, recent work has shown that compared to standard intrad…
View article: Robust IgM responses following vaccination are associated with prevention of<i>Mycobacterium tuberculosis</i>infection in macaques
Robust IgM responses following vaccination are associated with prevention of<i>Mycobacterium tuberculosis</i>infection in macaques Open
Development of an effective tuberculosis (TB) vaccine has suffered from an incomplete understanding of the correlates of protection against Mycobacterium tuberculosis ( Mtb ). However, recent work has shown that compared to standard intrad…
View article: Lung myeloid cell interferon response correlates with clearance of SARS-CoV-2
Lung myeloid cell interferon response correlates with clearance of SARS-CoV-2 Open
This is the dataset for representative confocal figures in this article.
View article: Antiretroviral therapy does not reduce tuberculosis reactivation in a tuberculosis-HIV coinfection model
Antiretroviral therapy does not reduce tuberculosis reactivation in a tuberculosis-HIV coinfection model Open
While the advent of combination antiretroviral therapy (ART) has significantly improved survival, tuberculosis (TB) remains the leading cause of death in the HIV-infected population. We used Mycobacterium tuberculosis/simian immunodeficien…
View article: LAG-3 potentiates the survival of Mycobacterium tuberculosis in host phagocytes by modulating mitochondrial signaling in an in-vitro granuloma model
LAG-3 potentiates the survival of Mycobacterium tuberculosis in host phagocytes by modulating mitochondrial signaling in an in-vitro granuloma model Open
CD4+ T-cell mediated Th1 immune responses are critical for immunity to TB. The immunomodulatory protein, lymphocyte activation gene-3 (LAG-3) decreases Th1-type immune responses in T-cells. LAG-3 expression is significantly induced in the …