Shanthy Sundaram
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View article: cMET inhibitor crizotinib impairs angiogenesis and reduces tumor burden in the C3(1)-Tag model of basal-like breast cancer
cMET inhibitor crizotinib impairs angiogenesis and reduces tumor burden in the C3(1)-Tag model of basal-like breast cancer Open
Epidemiologic studies have associated obesity with increased risk of the aggressive basal-like breast cancer (BBC) subtype. Hepatocyte growth factor (HGF) signaling through its receptor, cMET, is elevated in obesity and is a pro-tumorigeni…
View article: Role of HGF in obesity-associated tumorigenesis: C3(1)-TAg mice as a model for human basal-like breast cancer
Role of HGF in obesity-associated tumorigenesis: C3(1)-TAg mice as a model for human basal-like breast cancer Open
Obesity is associated with basal-like breast cancer (BBC), an aggressive breast cancer subtype. The objective of this study was to determine whether obesity promotes BBC onset in adulthood and to evaluate the role of stromal-epithelial int…
View article: Weight loss reversed obesity-induced HGF/c-Met pathway and basal-like breast cancer progression
Weight loss reversed obesity-induced HGF/c-Met pathway and basal-like breast cancer progression Open
Epidemiologic studies demonstrate that obesity is associated with an aggressive subtype of breast cancer called basal-like breast cancer (BBC). Using the C3(1)-TAg murine model of BBC, we previously demonstrated that mice displayed an earl…
View article: Restoration of the soil fertility under Cr (VI) and Artificial drought condition by the utilization of plant growth promoting Bacillus spp. SSAU2
Restoration of the soil fertility under Cr (VI) and Artificial drought condition by the utilization of plant growth promoting Bacillus spp. SSAU2 Open
The study explores the potential of an indigenous halo-tolerant microbe identified as Bacillus spp. SSAU-2 in enhancing soil fertility and promoting plant growth for sustainable agricultural practices under the influence of multiple abioti…
View article: Global Comparison of Health Policies Focused on Gestational Diabetes: Recognizing Pertinent Gaps
Global Comparison of Health Policies Focused on Gestational Diabetes: Recognizing Pertinent Gaps Open
Introduction: Gestational diabetes mellitus (GDM) is a condition that affects 14.7% of women globally and occurs when a mother develops diabetes during the course of her pregnancy.1 Increased insulin resistance in pregnant mothers can lead…
View article: Comparative Analysis of Antibacterial Activity of Banana Peel at Different Stages of Ripening
Comparative Analysis of Antibacterial Activity of Banana Peel at Different Stages of Ripening Open
The present study investigated the phenolic compounds like tannin and flavonoids that provide banana peel extracts their antibacterial properties against bacterial pathogens, i.e., Enterobacter. aerogenes, Pseudomonas. aeruginosa, Salmonel…
View article: Crafting the Synergistic Fusion of Algal Cultivation with Effective Industrial CO2 Mitigation
Crafting the Synergistic Fusion of Algal Cultivation with Effective Industrial CO2 Mitigation Open
Amongall challenges facing humanity today, global warming has become a major concern in the last two decades due to an increase of almost 2.41 mg.L -1 of carbon dioxide (CO 2 ) every year in the atmosphere from burning fossil fuels. Althou…
View article: COMPARATIVE STUDY ON NUTRIENT COMPOSITION AND FUNCTIONAL CHARACTERISTICS OF TROPICAL FRUITS WITH EMPHASIS ON BANANA FRUIT PEEL
COMPARATIVE STUDY ON NUTRIENT COMPOSITION AND FUNCTIONAL CHARACTERISTICS OF TROPICAL FRUITS WITH EMPHASIS ON BANANA FRUIT PEEL Open
Objective: To determine the nutritional and anti-nutritional components of banana peel at various stages of ripening and compared it with tropical fruits (apple and mango). Methods: Initially, nutrient values for individual fruits and its …
View article: NUTRACEUTICAL APPLICATION AND INDUSTRIAL UTILIZATION OF BANANA (MUSA PARADISICA L. VARIETY “BHUSAWAL KELI”) PEELS (REVIEW ARTICLE)
NUTRACEUTICAL APPLICATION AND INDUSTRIAL UTILIZATION OF BANANA (MUSA PARADISICA L. VARIETY “BHUSAWAL KELI”) PEELS (REVIEW ARTICLE) Open
The main by-product of the banana processing industry is peel, which represents almost 30% of fruit. Naturally occurring substances are cheap, renewable, biodegradable, do not contain heavy metals or other toxic chemicals, are therefore ec…
View article: PHOTOLUMINESCENCE INVESTIGATIONS OF TRANSITION METAL (Ni, Co) DOPED ZnS NANOCRYSTALS
PHOTOLUMINESCENCE INVESTIGATIONS OF TRANSITION METAL (Ni, Co) DOPED ZnS NANOCRYSTALS Open
In the present investigation, Nickle and Cobalt (Transition metals) doped ZnS Nanocrystals were synthesized by wet chemical route using methanol water binary mixture as a solvent. 1-20% doped percent of dopant were used. The synthesized sa…
View article: Development of a Diatom-Based Photoluminescent Immunosensor for the Early Detection of Karnal Bunt Disease of Wheat Crop
Development of a Diatom-Based Photoluminescent Immunosensor for the Early Detection of Karnal Bunt Disease of Wheat Crop Open
In India, the major crop is wheat. Its production is severely hampered by seed-borne diseases such as smut and bunt which are responsible for the reduction of crop yield with poor grain quality. In the current study, an attempt was made to…
View article: Sodium Antimony Gluconate leads to a predominant protective response during Visceral Leishmaniasis on triggering CD2 epitope
Sodium Antimony Gluconate leads to a predominant protective response during Visceral Leishmaniasis on triggering CD2 epitope Open
Background: Visceral Leishmaniasis is a macrophage associated disorder for the treatment of which antimony based drugs like SAG and SSG were the first choice in the recent past. The clinical value of antimony therapy is now declined agains…
View article: Anticancer potential of steviol in MCF-7 human breast cancer cells
Anticancer potential of steviol in MCF-7 human breast cancer cells Open
Steviol remarkably inhibited the growth MCF-7 HBCCs in a dose dependent mannerIt abolishes cell cycle progression by arresting cells at G2/M phaseSteviol induces the cells to undergo apoptosisSteviol induces the cells to generate reactive …
View article: Cumulative Effects of Ultraviolet Radiation and Photosyntheically Active Radiation on Phycobiliproteins of A Hot-Spring Cyanobacatrium Nostoc sp. strain HKAR-2
Cumulative Effects of Ultraviolet Radiation and Photosyntheically Active Radiation on Phycobiliproteins of A Hot-Spring Cyanobacatrium Nostoc sp. strain HKAR-2 Open
Cyanobacteria are cosmopolitan in distribution and have adapted to diverse habitats. Adaptation of cyanobacteria is one of the key factors to withstand harsh environmental conditions. We have investigated the effects of photosynthetically …
View article: Stevioside and rebaudioside A - predominant ent-kaurene diterpene glycosides of therapeutic potential: a review
Stevioside and rebaudioside A - predominant ent-kaurene diterpene glycosides of therapeutic potential: a review Open
Stevia rebaudiana (Bertoni) is a Paraguayan perennial herb of the family Asteraceae. The leaves contain a great amount of secondary metabolites with a wide range of important biological activities commonly known as steviol glycosides which…
View article: An analysis of phosphorylation sites in protein kinases from Leishmania
An analysis of phosphorylation sites in protein kinases from Leishmania Open
Protein kinases are promising drug targets for Leishmaniasis. We have evaluated the phosphorylation potential of protein kinases in different species and strains of Leishmania. Phosphorylation potential of serine, threonine and tyrosine re…
View article: Elucidating hydrogenase surfaces and tracing the intramolecular tunnels for hydrogenase inhibition in microalgal species
Elucidating hydrogenase surfaces and tracing the intramolecular tunnels for hydrogenase inhibition in microalgal species Open
Intramolecular tunnels are majorly attracting attention as possible pathways for entry of inhibitors like oxygen and carbon monoxide to the active sites of the enzymes, hydrogenases. The results of homology modeling of the HydSL protein, a…