Sheila K. Patel
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Real world diagnostic performance of plasma p-tau217 for early-onset Alzheimer's disease in a cognitive disorders tertiary care setting Open
Background Plasma p-tau217 shows exceptional diagnostic performance for Alzheimer's disease (AD) in cohort studies. Recent real-world studies support its validity in more diverse populations. Objective Test the performance of plasma p-tau2…
View article: Replication of SARS-CoV-2 Omicron lineages is defined by TMPRSS2 use in environments where ACE2 is complexed with solute carriers SLC6A19 and SLC6A20
Replication of SARS-CoV-2 Omicron lineages is defined by TMPRSS2 use in environments where ACE2 is complexed with solute carriers SLC6A19 and SLC6A20 Open
The Omicron variant of SARS-CoV-2 emerged in late 2021 and since then Omicron subvariants have continued to evolve and dominate globally. The viral S protein evolved towards highly efficient antibody evasion and replicative capacity in the…
View article: Promoting resilience to weather‐related and seasonal provocations to health in people with multimorbid heart disease: a prospective pragmatic, randomised trial
Promoting resilience to weather‐related and seasonal provocations to health in people with multimorbid heart disease: a prospective pragmatic, randomised trial Open
Objective To investigate whether a multifaceted intervention for building resilience to external provocations to health reduced the number of all‐cause hospital re‐admissions and deaths of people hospitalised with multimorbid heart disease…
View article: Neurofilament light chain and voice acoustics in dementia diagnosis (NAVAIDD): Protocol for a cohort study assessing the real-world diagnostic utility of blood and digital biomarkers in clinical settings
Neurofilament light chain and voice acoustics in dementia diagnosis (NAVAIDD): Protocol for a cohort study assessing the real-world diagnostic utility of blood and digital biomarkers in clinical settings Open
Background The advent of disease modifying therapies for dementia has highlighted the need for simple, accessible and low-cost diagnostic tests. Blood and digital biomarkers increase accuracy in highly selected research populations. Howeve…
Impact of type 2 diabetes mellitus on brain volumes and cognitive performance Open
Background Type 2 diabetes (T2DM) is recognised as a major contributor to cognitive decline. People with T2DM demonstrate abnormalities on MRI compared to control individuals. The aim of this analysis was to investigate differences in cogn…
View article: TMPRSS2 activation of Omicron lineage Spike glycoprotein is regulated by Collectrin-like domain of ACE2
TMPRSS2 activation of Omicron lineage Spike glycoprotein is regulated by Collectrin-like domain of ACE2 Open
Continued high-level spread of SARS-CoV-2 has enabled an accumulation of changes within the Spike glycoprotein, leading to resistance to neutralising antibodies and concomitant changes to entry requirements that increased viral transmissio…
View article: Vulnerability to environmental and climatic health provocations among women and men hospitalized with chronic heart disease: insights from the RESILIENCE TRIAL cohort
Vulnerability to environmental and climatic health provocations among women and men hospitalized with chronic heart disease: insights from the RESILIENCE TRIAL cohort Open
Aims We aimed to recruit a representative cohort of women and men with multi-morbid chronic heart disease as part of a trial testing an innovative, nurse-co-ordinated, multi-faceted intervention to lower rehospitalization and death by addr…
View article: Corrigendum: Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2
Corrigendum: Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2 Open
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View article: Plasma Angiotensin Converting Enzyme 2 (ACE2) Activity in Healthy Controls and Patients with Cardiovascular Risk Factors and/or Disease
Plasma Angiotensin Converting Enzyme 2 (ACE2) Activity in Healthy Controls and Patients with Cardiovascular Risk Factors and/or Disease Open
Angiotensin converting enzyme 2 (ACE2) is an endogenous negative regulator of the renin-angiotensin system, a key factor in the development of cardiovascular disease (CVD). ACE2 is also used by SARS-CoV-2 for host cell entry. Given that CO…
Plasma Neurofilament Light Chain and Clinical Diagnosis in Frontotemporal Dementia Syndromes Open
Background: Frontotemporal dementia (FTD) syndromes, mimics, phenocopy (phFTD), and slowly progressive behavioral variant FTD (bvFTD) can be difficult to distinguish clinically. Biomarkers such as neurofilament light chain (NfL) may be hel…
2291 Plasma neurofilament light chain and clinical diagnosis in frontotemporal dementia syndromes Open
Objective To study plasma NfL levels in people with frontotemporal dementia (FTD) syndromes and determine if plasma NfL can distinguish between FTD syndromes and FTD phenocopy, whom are difficult to clinically distinguish from bvFTD. Metho…
View article: Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2
Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2 Open
Joining a function-enhanced Fc-portion of human IgG to the SARS-CoV-2 entry receptor ACE2 produces an antiviral decoy with strain transcending virus neutralizing activity. SARS-CoV-2 neutralization and Fc-effector functions of ACE2-Fc deco…
Improved tissue preparation for multimodal vibrational imaging of biological tissues Open
The complementary nature of Infrared (IR) and Raman spectroscopies enables a thorough understanding of biological tissue – so called multimodal vibrational spectroscopic imaging. However, new approaches in terms of sample preparation and d…
Immunological dysfunction persists for 8 months following initial mild-moderate SARS-CoV-2 infection Open
A proportion of patients surviving acute COVID-19 infection develop post-COVID syndrome (long COVID) encompassing physical and neuropsychiatric symptoms lasting longer than 12 weeks. Here we studied a prospective cohort of individuals with…
Plasma ACE2 activity is persistently elevated following SARS-CoV-2 infection: implications for COVID-19 pathogenesis and consequences Open
Coronavirus disease 2019 (COVID-19) causes persistent endothelial inflammation, lung, cardiovascular, kidney and neurological complications, and thromboembolic phenomena of unclear pathogenesis [1]. Severe acute respiratory syndrome-corona…
Comparison of brain atrophy and cognitive performance in individuals with low and high cardiovascular risk: Data from the Diabetes and Dementia (D2) Study Open
Background Growing evidence suggests that increased cardiovascular risk might accelerate brain atrophy and cognitive decline. The aim of this analysis was to investigate associations between the Framingham Risk Score (FRS), brain volume an…
Cognitive and imaging impacts of left ventricular hypertrophy in people with type 2 diabetes Open
Background Older adults with type 2 diabetes mellitus (T2DM) are at an increased risk of cognitive decline and dementia. Left ventricular hypertrophy (LVH) is prevalent in T2DM and is independently associated with cognitive decline. We con…
Plasma desmosine, a biomarker of elastin degradation, predicts outcomes in coronary artery disease Open
Background Recent evidence from animal studies suggests that elastin degradation accelerates atherosclerosis and increases risk of plaque rupture and subsequent myocardial infarction and stroke. Desmosine is an elastin-specific degradation…
Plasma ACE2 activity is persistently elevated following SARS-CoV-2 infection: implications for COVID-19 pathogenesis and consequences Open
COVID-19 causes persistent endothelial inflammation, lung and cardiovascular complications. SARS-CoV-2 utilises the catalytic site of full-length membrane-bound angiotensin converting enzyme 2 (ACE2) for cell entry causing downregulation o…
Impaired retinal microvascular function predicts long-term adverse events in patients with cardiovascular disease Open
Aims Endothelial dysfunction is a precursor to the development of symptomatic atherosclerosis. Retinal microvascular reactivity to flicker light stimulation is a marker of endothelial function and can be quantified in vivo. We sought to de…
View article: Pharmacological and non-pharmacological treatments for major depressive disorder: review of systematic reviews
Pharmacological and non-pharmacological treatments for major depressive disorder: review of systematic reviews Open
This study aims to summarise the evidence on more than 140 pharmacological and non-pharmacological treatment options for major depressive disorder (MDD) and to evaluate the confidence that patients and clinicians can have in the underlying…