So-Yi Chang
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View article: Novel precision-cut lung slice immune co-culture models to study macrophage and fibroblast interactions in pulmonary fibrosis 3481
Novel precision-cut lung slice immune co-culture models to study macrophage and fibroblast interactions in pulmonary fibrosis 3481 Open
Description Precision-cut lung slices (PCLS) are widely used ex vivo models for studying lung fibrosis but traditionally lack immune cell infiltration, which is critical for understanding inflammation and fibrosis. To address this limitati…
View article: Tobacco smoking drives pro-fibrotic immune modulation and CD40L dysregulation in pulmonary fibrosis 3458
Tobacco smoking drives pro-fibrotic immune modulation and CD40L dysregulation in pulmonary fibrosis 3458 Open
Description Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a median survival of less than five years. Tobacco smoking (TS) is a significant risk factor, driving disease onset and progression; however, accurate bioma…
View article: Repurposing flavopiridol as an inhaled therapeutic for pulmonary fibrosis
Repurposing flavopiridol as an inhaled therapeutic for pulmonary fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease with limited therapeutic options. Cyclin-dependent kinase 9 (CDK9), a key transcriptional regulator, has been implicated in fibrotic diseases, but no therapies t…
View article: Autologous precision-cut lung slice co-culture models for studying macrophage-driven fibrosis
Autologous precision-cut lung slice co-culture models for studying macrophage-driven fibrosis Open
Precision-cut lung slices (PCLS) are commonly used as an ex vivo model to study lung fibrosis; however, traditional models lack immune cell infiltration, including the recruitment of monocytes and macrophages, which are critical for inflam…
View article: HOXA5 Inhibits Metastasis via Regulating Cytoskeletal Remodelling and Associates with Prolonged Survival in Non-Small-Cell Lung Carcinoma
HOXA5 Inhibits Metastasis via Regulating Cytoskeletal Remodelling and Associates with Prolonged Survival in Non-Small-Cell Lung Carcinoma Open
Homeobox genes comprise a family of regulatory genes that contain a common homeobox domain and act as transcription factors. Recent studies indicate that homeobox A5 (HOXA5) may serve as a tumour suppressor gene in breast cancers. However,…