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View article: Seipin Governs caveolin-1 trafficking through modulating sphingolipid-glycerolipid balance
Seipin Governs caveolin-1 trafficking through modulating sphingolipid-glycerolipid balance Open
View article: Extracellular vesicles carrying surface-anchored adiponectin prevent obesity-related metabolic complications by enhancing insulin sensitivity
Extracellular vesicles carrying surface-anchored adiponectin prevent obesity-related metabolic complications by enhancing insulin sensitivity Open
Adiponectin (Adpn) is a potent insulin-sensitizing adipokine with therapeutic promise for type 2 diabetes (T2D) and metabolic dysfunction-associated steatohepatitis (MASH). Its clinical use remains limited due to difficulties in producing …
View article: Exploring adipose tissue-derived extracellular vesicles in inter-organ crosstalk: Implications for metabolic regulation and adipose tissue function
Exploring adipose tissue-derived extracellular vesicles in inter-organ crosstalk: Implications for metabolic regulation and adipose tissue function Open
Intercellular and inter-organ communication systems are vital for tissue homeostasis and disease development, utilizing soluble bioactive molecules for signaling. The field of extracellular vesicle (EV) biology has rapidly expanded in rece…
View article: Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties
Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties Open
Recent evidence supporting that adipose tissue (AT)-derived extracellular vesicles (EVs) carry an important part of the AT secretome led us to characterize the EV-adipokine profile. In addition to evidencing a high AT-derived EV secretion …
View article: Lipidomic analysis of adipose-derived extracellular vesicles reveals specific EV lipid sorting informative of the obesity metabolic state
Lipidomic analysis of adipose-derived extracellular vesicles reveals specific EV lipid sorting informative of the obesity metabolic state Open
Adipose extracellular vesicles (AdEVs) transport lipids that could participate in the development of obesity-related metabolic dysfunctions. This study aims to define mouse AdEV lipid signature by a targeted LC-MS/MS approach in either hea…
View article: Adipocyte-Derived Extracellular Vesicles: Caveolin Matters
Adipocyte-Derived Extracellular Vesicles: Caveolin Matters Open
View article: Not Enough Fat: Mouse Models of Inherited Lipodystrophy
Not Enough Fat: Mouse Models of Inherited Lipodystrophy Open
Lipodystrophies belong to the heterogenous group of syndromes in which the primary defect is a generalized or partial absence of adipose tissue, which may be congenital or acquired in origin. Lipodystrophy should be considered in patients …
View article: Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes
Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes Open
View article: Extracellular Vesicles are Stable Carriers of Adiponectin with Insulin-Sensitive Properties
Extracellular Vesicles are Stable Carriers of Adiponectin with Insulin-Sensitive Properties Open
View article: Lipidomic analysis of adipose-derived extracellular vesicles reveals their potential as lipid mediators of obesity-associated metabolic complications
Lipidomic analysis of adipose-derived extracellular vesicles reveals their potential as lipid mediators of obesity-associated metabolic complications Open
Adipose extracellular vesicles (AdEV) transport lipids that could participate to the development of obesity-related metabolic dysfunctions. This study aimed to define mice AdEV lipid signature in either healthy or obesity context by a targ…
View article: Vésicules extracellulaires et maladies métaboliques
Vésicules extracellulaires et maladies métaboliques Open
Les vésicules extracellulaires (VE) correspondent à un ensemble hétérogène de nanovésicules membranaires sécrétées dans le milieu extracellulaire et circulant dans les différents fluides de l’organisme. Ces VE véhiculent du matériel biolog…
View article: Adipocyte‐derived extracellular vesicles in health and diseases: Nano‐packages with vast biological properties
Adipocyte‐derived extracellular vesicles in health and diseases: Nano‐packages with vast biological properties Open
As the largest human energy reservoir, adipocytes drive an intense dialog with other cells/organs throughout the body to regulate the size of adipose tissue and to communicate with other metabolic tissues and the brain to regulate energy s…
View article: Adipocyte-Derived Extracellular Vesicles: State of the Art
Adipocyte-Derived Extracellular Vesicles: State of the Art Open
White adipose tissue (WAT) is involved in long-term energy storage and represents 10–15% of total body weight in healthy humans. WAT secretes many peptides (adipokines), hormones and steroids involved in its homeostatic role, especially in…
View article: LPS-enriched small extracellular vesicles from metabolic syndrome patients trigger endothelial dysfunction by activation of TLR4
LPS-enriched small extracellular vesicles from metabolic syndrome patients trigger endothelial dysfunction by activation of TLR4 Open
View article: Sonic Hedgehog receptor Patched deficiency in astrocytes enhances glucose metabolism in mice
Sonic Hedgehog receptor Patched deficiency in astrocytes enhances glucose metabolism in mice Open
View article: Lipidomic Analysis of Adipose-Derived Extracellular Vesicles Reveals Their Potential as Lipid Mediators of Obesity-Associated Metabolic Complications
Lipidomic Analysis of Adipose-Derived Extracellular Vesicles Reveals Their Potential as Lipid Mediators of Obesity-Associated Metabolic Complications Open
View article: Intermittent Hypoxia Mediates Caveolae Disassembly That Parallels Insulin Resistance Development
Intermittent Hypoxia Mediates Caveolae Disassembly That Parallels Insulin Resistance Development Open
Repetitive complete or incomplete pharyngeal collapses are leading to chronic intermittent hypoxia (CIH), a hallmark feature of obstructive sleep apnea (OSA) syndrome responsible for many metabolic disorders. In humans, an association betw…
View article: Large Extracellular Vesicle-Associated Rap1 Accumulates in Atherosclerotic Plaques, Correlates With Vascular Risks and Is Involved in Atherosclerosis
Large Extracellular Vesicle-Associated Rap1 Accumulates in Atherosclerotic Plaques, Correlates With Vascular Risks and Is Involved in Atherosclerosis Open
Rationale: Metabolic syndrome (MetS) is a cluster of interrelated risk factors for cardiovascular diseases and atherosclerosis. Circulating levels of large extracellular vesicles (lEVs), submicrometer-sized vesicles released from plasma me…
View article: Exosomes, vésicules extracellulaires et dialogue inter-organes
Exosomes, vésicules extracellulaires et dialogue inter-organes Open
View article: Ethanol Extract of Leaves of<i>Cassia siamea Lam</i>Protects against Diabetes-Induced Insulin Resistance, Hepatic, and Endothelial Dysfunctions in<i>ob/ob</i>Mice
Ethanol Extract of Leaves of<i>Cassia siamea Lam</i>Protects against Diabetes-Induced Insulin Resistance, Hepatic, and Endothelial Dysfunctions in<i>ob/ob</i>Mice Open
Despite long traditional utilization and some reports on the antihyperglycemic and antihyperlipidemic action of Cassia siamea , the mechanisms involved have not been investigated yet. Thus, the objective of the present study was to investi…
View article: Caveolae: The FAQs
Caveolae: The FAQs Open
Caveolae are an abundant, but enigmatic, plasma membrane feature of vertebrate cells. In this brief commentary, the authors attempt to answer some key questions related to the formation and function of caveolae based on round‐table discuss…
View article: Vésicules extracellulaires, biomarqueurs et bioeffecteurs du syndrome métabolique
Vésicules extracellulaires, biomarqueurs et bioeffecteurs du syndrome métabolique Open
Les vésicules extracellulaires (VE) suscitent un intérêt croissant lié à leur capacité à transférer du contenu biologique entre cellules. Les VE, émises dans l’espace extracellulaire, circulent via les différents fluides de l’organisme et …
View article: Phenotyping of circulating extracellular vesicles (EVs) in obesity identifies large EVs as functional conveyors of Macrophage Migration Inhibitory Factor
Phenotyping of circulating extracellular vesicles (EVs) in obesity identifies large EVs as functional conveyors of Macrophage Migration Inhibitory Factor Open
View article: Extracellular vesicles and cardiovascular disease therapy
Extracellular vesicles and cardiovascular disease therapy Open
Cardiovascular disease (CVD) constitutes one of the leading causes of mortality worldwide, therefore representing a major public health concern. Despite recent advances in the treatment of patients with acute myocardial infarction (AMI), s…
View article: Normal human adipose tissue functions and differentiation in patients with biallelic LPIN1 inactivating mutations
Normal human adipose tissue functions and differentiation in patients with biallelic LPIN1 inactivating mutations Open
View article: Estrogen receptor α/HDAC/NFAT axis for delphinidin effects on proliferation and differentiation of T lymphocytes from patients with cardiovascular risks
Estrogen receptor α/HDAC/NFAT axis for delphinidin effects on proliferation and differentiation of T lymphocytes from patients with cardiovascular risks Open
View article: Characterisation of adipocyte‐derived extracellular vesicle subtypes identifies distinct protein and lipid signatures for large and small extracellular vesicles
Characterisation of adipocyte‐derived extracellular vesicle subtypes identifies distinct protein and lipid signatures for large and small extracellular vesicles Open
Extracellular vesicles (EVs) are biological vectors that can modulate the metabolism of target cells by conveying signalling proteins and genomic material. The level of EVs in plasma is significantly increased in cardiometabolic diseases a…
View article: FGF21 Improves the Adipocyte Dysfunction Related to Seipin Deficiency
FGF21 Improves the Adipocyte Dysfunction Related to Seipin Deficiency Open
Fibroblast growth factor 21 (FGF21) was shown to improve metabolic homeostasis, at least partly by controlling white adipocyte profile and adiponectin secretion. Here, we studied its effect on adipocyte dysfunction in the context of Berard…
View article: Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway
Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway Open