Sobhan Roy
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View article: Molecular characterization of the archaic HLA-B∗73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2
Molecular characterization of the archaic HLA-B∗73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2 Open
HLA class I alleles of archaic origin may have been retained in modern humans because they provide immunity against diseases to which archaic humans had evolved resistance. According to this model, archaic introgressed alleles were somehow…
View article: Molecular characterization of the archaic HLA-B*73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2
Molecular characterization of the archaic HLA-B*73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2 Open
HLA class I alleles of archaic origin may have been retained in modern humans because they provide immunity against diseases to which archaic humans had evolved resistance. According to this model, archaic introgressed alleles were somehow…
View article: Ligand-induced segregation from large cell-surface phosphatases is a critical step in γδ TCR triggering
Ligand-induced segregation from large cell-surface phosphatases is a critical step in γδ TCR triggering Open
Gamma/delta (γδ) T cells are unconventional lymphocytes that recognize diverse ligands via somatically recombined T cell antigen receptors (γδ TCRs). The molecular mechanism by which ligand recognition initiates γδ TCR signaling, a process…
View article: Ligand-induced segregation from large cell-surface phosphatases is a critical step in γδ TCR triggering
Ligand-induced segregation from large cell-surface phosphatases is a critical step in γδ TCR triggering Open
Gamma/delta (γδ) T cells are unconventional adaptive lymphocytes that recognize structurally diverse ligands via somatically-recombined antigen receptors (γδ TCRs). The molecular mechanism by which ligand recognition initiates γδ TCR signa…
View article: MAIT cells are imprinted by the microbiota in early life and promote tissue repair
MAIT cells are imprinted by the microbiota in early life and promote tissue repair Open
Commensals rule the MAITrix Mucosal-associated invariant T (MAIT) cells play an important role in mucosal homeostasis. MAIT cells recognize microbial small molecules presented by the major histocompatibility complex class Ib molecule MR1. …
View article: TCR–pMHC bond conformation controls TCR ligand discrimination
TCR–pMHC bond conformation controls TCR ligand discrimination Open
A major unanswered question is how a TCR discriminates between foreign and self-peptides presented on the APC surface. Here, we used in situ fluorescence resonance energy transfer (FRET) to measure the distances of single TCR–pMHC bonds an…
View article: Generation and molecular recognition of melanoma-associated antigen-specific human γδ T cells
Generation and molecular recognition of melanoma-associated antigen-specific human γδ T cells Open
Benveniste et al. have uncovered γδ T cells that recognize peptide antigens in an MHC-restricted manner.
View article: Modulation of Juvenile Hormone Analogue (Jha) Mimic on Larval Instars of Tropical Tasar Silk Insect (Lepidoptera: Saturniidae) to Elucidate the State of Silk Performance Parameters
Modulation of Juvenile Hormone Analogue (Jha) Mimic on Larval Instars of Tropical Tasar Silk Insect (Lepidoptera: Saturniidae) to Elucidate the State of Silk Performance Parameters Open
The present paper deals with the effect of Samrudhi, a Juvenile Hormone Analogue (JHA) mimic on 5 th instars larvae of Antherea mylitta D. and was studied at interval of 48, 72 and 96 hours for knowing silk performance parameters viz.larva…
View article: MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates
MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates Open
Studies on mucosal-associated invariant T cells (MAITs) in nonhuman primates (NHP), a physiologically relevant model of human immunity, are handicapped due to a lack of macaque MAIT-specific reagents. Here we show that while MR1 ligand-con…
View article: Molecular Analysis of Lipid-Reactive Vδ1 γδ T Cells Identified by CD1c Tetramers
Molecular Analysis of Lipid-Reactive Vδ1 γδ T Cells Identified by CD1c Tetramers Open
CD1c is abundantly expressed on human dendritic cells (DC) and B cells, where it binds and displays lipid Ags to T cells. In this study, we report that CD1c tetramers carrying Mycobacterium tuberculosis phosphomycoketide bind γδ TCRs. An u…