Explanipedia

Procalcitonin use in febrile children attending European emergency departments: a prospective multicenter study Open

Dorine Borensztajn, Joany M. Zachariasse, Enitan D. Carrol, Ruud Nijman, Ulrich von Both , et al. · 2025

Heterozygous <i>BTNL8</i> variants in individuals with multisystem inflammatory syndrome in children (MIS-C) Open

Evangelos Bellos, David Santillo, Pierre Vantourout, Heather Jackson, Amédine Duret , et al. · 2024

Multisystem inflammatory syndrome in children (MIS-C) is a rare condition following SARS-CoV-2 infection associated with intestinal manifestations. Genetic predisposition, including inborn errors of the OAS-RNAseL pathway, has been reporte…

Shared neutrophil and T cell dysfunction is accompanied by a distinct interferon signature during severe febrile illnesses in children Open

Harsita Patel, Michael J. Carter, Heather Jackson, Oliver Powell, Matthew Fish , et al. · 2024

Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort study Open

Luregn J. Schlapbach, Devika Ganesamoorthy, Clare Wilson, Sainath Raman, Shane George , et al. · 2024

Conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU): a UK multicentre, open, parallel-group, randomised clinical trial Open

Mark Peters, Doug W Gould, Samiran Ray, Karen Thomas, Irene Chang , et al. · 2023

UK National Institute for Health and Care Research Health Technology Assessment Programme.

Raising AWaRe-ness of Antimicrobial Stewardship Challenges in Pediatric Emergency Care: Results from the PERFORM Study Assessing Consistency and Appropriateness of Antibiotic Prescribing Across Europe Open

Laura Kolberg, Aakash Khanijau, Fabian van der Velden, Jethro Herberg, Tisham De , et al. · 2023

Background Optimization of antimicrobial stewardship is key to tackling antimicrobial resistance, which is exacerbated by overprescription of antibiotics in pediatric emergency departments (EDs). We described patterns of empiric antibiotic…

Immunology of severe febrile illness in children in the COVID-19 era Open

Manu Shankar‐Hari, Harsita Patel, Michael J. Carter, Heather Jackson, Oliver Powell , et al. · 2023

Severe febrile illnesses in children, such as multi-system inflammatory syndrome in children (MIS-C), severe bacterial infection (SBI), severe viral infection (SVI), and Kawasaki disease (KD), have shared clinical features. We used immunop…

Biobanking and consenting to research: a qualitative thematic analysis of young people’s perspectives in the North East of England Open

Fabian van der Velden, Emma Lim, Lily Gills, Jasmin Broadey, Louise Hayes , et al. · 2023

Emergency medical services utilisation among febrile children attending emergency departments across Europe: an observational multicentre study Open

Chantal Tan, Clementien L. Vermont, Joany M. Zachariasse, Ulrich von Both, Irini Eleftheriou , et al. · 2023

Evaluation of Autoantibody Binding to Cardiac Tissue in Multisystem Inflammatory Syndrome in Children and COVID-19 Vaccination–Induced Myocarditis Open

Harsita Patel, Amalia Sintou, Rasheda A. Chowdhury, Stephen Rothery, Alma Iacob , et al. · 2023

Importance Cardiac dysfunction and myocarditis have emerged as serious complications of multisystem inflammatory syndrome in children (MIS-C) and vaccines against SARS-CoV-2. Understanding the role of autoantibodies in these conditions is …

Genomic investigations of unexplained acute hepatitis in children Open

Sofia Morfopoulou, Sarah Buddle, Oscar Enrique Torres Montaguth, Laura Atkinson, José Afonso Guerra‐Assunção , et al. · 2023

Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK 1 . Here we report an investigation of 38 cases, 66 age-matched immuno…

Adeno-associated virus 2 infection in children with non-A–E hepatitis Open

Antonia Ho, Richard Orton, Rachel Tayler, Patawee Asamaphan, Vanessa Herder , et al. · 2023

Correction to: Group A streptococcal disease in paediatric inpatients: a European perspective Open

Navin P. Boeddha, Lucy Atkins, Ronald de Groot, Gertjan J. Driessen, Jan A. Hazelzet , et al. · 2023

Correction to: Febrile illness in high-risk children: a prospective, international observational study Open

Fabian van der Velden, Gabriella de Vries, Alexander Martín, Emma Lim, Ulrich von Both , et al. · 2023

Group A streptococcal disease in paediatric inpatients: a European perspective Open

Navin P. Boeddha, Lucy Atkins, Ronald de Groot, Gertjan J. Driessen, Jan A. Hazelzet , et al. · 2022

Febrile illness in high-risk children: a prospective, international observational study Open

Fabian van der Velden, Gabriella de Vries, Alexander J. Martin, Emma Lim, Ulrich von Both , et al. · 2022

Guideline adherence in febrile children below 3 months visiting European Emergency Departments: an observational multicenter study Open

Chantal Tan, Eline E. P. L. van der Walle, Clementien L. Vermont, Ulrich von Both, Enitan D. Carrol , et al. · 2022

Plasma lipid profiles discriminate bacterial from viral infection in febrile children Open

Xinzhu Wang, Ruud Nijman, Stéphane Camuzeaux, Caroline Sands, Heather Jackson , et al. · 2019

Identification of regulatory variants associated with genetic susceptibility to meningococcal disease Open

Lisa Borghini, Eileen Png, Alexander Binder, Victoria Wright, Ellie Pinnock , et al. · 2019

Life-threatening infections in children in Europe (the EUCLIDS Project): a prospective cohort study Open

Federico Martinón‐Torres, Antonio Salas, Irene Rivero‐Calle, Miriam Cebey‐López, Jacobo Pardo‐Seco , et al. · 2018

Natural resistance to Meningococcal Disease related to CFH loci: Meta-analysis of genome-wide association studies Open

Federico Martinón‐Torres, Eileen Png, Chiea Chuen Khor, Sonia Dávila, Victoria Wright , et al. · 2016

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