Explanipedia

Differences in pulmonary nodular consolidation features among drug-sensitive pulmonary tuberculosis and multidrug/extensively-resistant pulmonary tuberculosis: a multi-national multi-center study Open

Sheng-Nan Tang, Xi-Ling Huang, Alena Skrahina, Qiuting Zheng, Aleh Tarasau , et al. · 2025

MDR/XDR patients exhibit significantly higher PN prevalence and more extensive pulmonary involvement compared to DS patients and which is not totally determined by disease history length, suggesting that PN characteristics could serve as i…

Evaluation of two short standardised regimens for the treatment of rifampicin-resistant tuberculosis (STREAM stage 2): an open-label, multicentre, randomised, non-inferiority trial Open

Ruth Goodall, Sarah Meredith, Andrew Nunn, Adamu Bayissa, Anuj Bhatnagar , et al. · 2022

USAID and Janssen Research & Development.

Phylogeography and transmission of M. tuberculosis in Moldova: A prospective genomic analysis Open

Chongguang Yang, Benjamin Sobkowiak, Vijay Naidu, Alexandru Codreanu, Nelly Ciobanu , et al. · 2022

Background The incidence of multidrug-resistant tuberculosis (MDR-TB) remains critically high in countries of the former Soviet Union, where >20% of new cases and >50% of previously treated cases have resistance to rifampin and isoniazid. …

Evolution and emergence of multidrug-resistant Mycobacterium tuberculosis in Chisinau, Moldova Open

Tyler S. Brown, Vegard Eldholm, Ola Brynildsrud, Magnus N Osnes, Natalie S. Levy , et al. · 2021

The evolution and emergence of drug-resistant tuberculosis (TB) has been studied extensively in some contexts, but the ecological drivers of these two processes remain poorly understood. This study sought to describe the joint evolutionary…

Phylogeography and transmission of <i>M. tuberculosis</i> in Moldova Open

Chongguang Yang, Benjamin Sobkowiak, Vijay Naidu, Alexandru Codreanu, Nelly Ciobanu , et al. · 2021

Background The incidence of multidrug-resistant tuberculosis (MDR-TB) remains critically high in countries of the former Soviet Union, where >20% of new cases and >50% of previously-treated cases have resistance to rifampin and isoniazid. …

Characteristics of deaths by recurrence of lung tuberculosis Open

Haidarlî Ion, Elena Tudor, Sofia Alexandru, Rîvneac Lidia, Valentina Bolotnicov , et al. · 2021

From the existent data about the mortality through recedived pulmonary tuberculosis there were analyzed specific particularities of these in 2015-2017. So, the mortality through tuberculosis recidived and its complications constitution 1,2…

Interaction of anti-tuberculosis preparations with drugs used in COVID-19 Open

Nicolae Bacinschi, Sofia Alexandru, Anna Donica, Elena Tudor, Anastasia Caracaş , et al. · 2021

The COVID-19 pandemic has raised new global health issues, including overlapping SARS CoV-2 infection with tuberculosis, HIV/AIDS, marked by high morbidity and mortality. The treatment of these infections has raised from the outset the eff…

Evolution and emergence of multidrug-resistant <i>Mycobacterium tuberculosis</i> in Chisinau, Moldova Open

Tyler S. Brown, Vegard Eldholm, Ola Brynildsrud, Magnus N Osnes, Natalie Stennis , et al. · 2021

1. ABSTRACT Background Drug-resistant tuberculosis is a high priority threat to global public health. There are still critical gaps in understanding how novel drug-resistant M. tuberculosis strains emerge and, once emergent, what drives th…

Impact of bedaquiline on treatment outcomes of multidrug-resistant tuberculosis in a high-burden country Open

Dumitru Chesov, Jan Heyckendorf, Sofia Alexandru, Ana Donica, Elena Chesov , et al. · 2020

Background Evaluation of novel anti-tuberculosis (TB) drugs for the treatment of multidrug-resistant (MDR)-TB continues to be of high interest on the TB research agenda. We assessed treatment outcomes in patients with pulmonary MDR-TB who …

Vaccinul BCG şi infecţia cu SARS-CoV-2 Open

Nicolae Bacinschi, Sofia Alexandru, A. David, Anna Donica, Liuba Nepoliuc , et al. · 2020

Until the development of a specific vaccine, the COVID-19 pandemic, determined by the new type of coronavirus, SARS-CoV-2, requires therapeutic interventions capable of influencing the morbidity and mortality in healthy and infected indivi…

Treatment outcome in patients with MDR-TB treated with bedaquiline containing regimens, Republic of Moldova Open

Dumitru Chesov, Jan Heyckendorf, Maja Reiman, Sofia Alexandru, Ana Donica , et al. · 2020

Aim: To assess the treatment outcome in patients who received bedaquiline containing MDR-TB treatment regimens in the Republic of Moldova. Methods: We systematically analyzed the national electronic TB database and performed …

BCG vaccine and SARS-CoV-2 infection Open

Nicolae Bacinschi, Sofia Alexandru, A. David, Anna Donica, Liuba Nepoliuc , et al. · 2020

Until the development of a specific vaccine, the COVID-19 pandemic, determined by the new type of coronavirus, SARS-CoV-2, requires therapeutic interventions capable of influencing the morbidity and mortality in healthy and infected indivi…

Prediction of multiple drug resistant pulmonary tuberculosis against drug sensitive pulmonary tuberculosis by CT nodular consolidation sign Open

Xi-Ling Huang, Aliaksandr Skrahin, Pu-Xuan Lu, Sofia Alexandru, Valeriu Crudu , et al. · 2019

Multidrug-resistant tuberculosis (mdrtb) refers to TB infection resistant to at least two most powerful anti-TB drugs, isoniazid and rifampincin. It has been estimated that globally 3.5% (which can be much higher in some regions) of newly …

Direcţii de cercetare şi elaborare de preparate antituberculoase Open

Nicolae Bacinschi, Sofia Alexandru, Anna Donica, Ina Guţu · 2019

The increasing incidence of new cases of tuberculosis, of latent forms and with multiple and extended resistance, required the acceleration of the research and elaboration of the anti-tuberculosis drugs by elucidating new targets. The main…

Directions for research and development of anti-tuberculosis drugs Open

Nicolae Bacinschi, Sofia Alexandru, Anna Donica, Ina Guţu · 2019

The increasing incidence of new cases of tuberculosis, of latent forms and with multiple and extended resistance, required the acceleration of the research and elaboration of the anti-tuberculosis drugs by elucidating new targets. The main…

Aspecte ale tratamentului pacienților cu diabet zaharat și tuberculoză Open

Nicolae Bacinschi, Anna Donica, Sofia Alexandru, Liubovi Nepoliuc, Serghei Ceban , et al. · 2019

Vitamins and tuberculosis Open

Nicolae Bacinschi, Sofia Alexandru, Anna Donica, Ina Guţu · 2019

The importance of vitamins to the development, progression and treatment of tuberculosis is indisputable due to the presence of hypovitaminosis in people with malnutrition or the increase of vitamin deficiency in the setting of the disease…

Vitaminele şi tuberculoza Open

Nicolae Bacinschi, Sofia Alexandru, Anna Donica, Ina Guţu · 2019

The importance of vitamins to the development, progression and treatment of tuberculosis is indisputable due to the presence of hypovitaminosis in people with malnutrition or the increase of vitamin deficiency in the setting of the disease…

Failing treatment of multidrug-resistant tuberculosis: a matter of definition Open

Dumitru Chesov, Sofia Alexandru, Valeriu Crudu, Nelly Ciobanu, Victor Botnaru , et al. · 2019

Assessing tuberculosis control priorities in high-burden settings: a modelling approach Open

Juan F. Vesga, Timothy B. Hallett, Michael Reid, Kuldeep Singh Sachdeva, Raghuram Rao , et al. · 2019

Building a tuberculosis-free world: The Lancet Commission on tuberculosis Open

Michael Reid, Nimalan Arinaminpathy, Amy Bloom, Barry R. Bloom, Catharina Boehme , et al. · 2019

THE CORRELATION BETWEEN LEVELS OF PHENOTYPIC RESISTANCE AND GENOTYPIC MUTATIONS OF M. TUBERCULOSIS Open

Nelly Ciobanu, Sofia Alexandru, Dumitru Chesov, Alexandru Codreanu, Christoph Lange , et al. · 2018

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Clinical Management of Multidrug-Resistant Tuberculosis in 16 European Countries Open

Gunar Günther, Frank van Leth, Sofia Alexandru, Neus Altet, Korkut Avsar , et al. · 2018

Conventional standard MDR-TB treatment regimens resulted in a higher frequency of failure compared with individualized treatments. Overall, cure from MDR-TB is substantially more frequent than previously anticipated, and poorly reflected b…

The TB Portals: an Open-Access, Web-Based Platform for Global Drug-Resistant-Tuberculosis Data Sharing and Analysis Open

Alex Rosenthal, Andrei Gabrielian, Eric Engle, Darrell E. Hurt, Sofia Alexandru , et al. · 2017

The TB Portals program is an international consortium of physicians, radiologists, and microbiologists from countries with a heavy burden of drug-resistant tuberculosis working with data scientists and information technology professionals.…

Treatment outcomes of MDR-TB and HIV co-infection in Europe Open

Cécile Magis-Escurra, Gunar Günther, Christoph Lange, Sofia Alexandru, Neus Altet , et al. · 2017

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Treatment Outcomes in Multidrug-Resistant Tuberculosis Open

Gunar Günther, Christoph Lange, Sofia Alexandru, Neus Altet, Korkut Avsar , et al. · 2016

Funded by the European Commission Seventh Framework \nProgram (FP7/2007-2013) under grant agreement FP7-223681 \n(TB-PANNET). Dr. Lange is supported by the German Center for \nInfection Research (DZIF).

Multidrug-Resistant Tuberculosis in Europe, 2010–2011 Open

Gunar Günther, Frank van Leth, Sofia Alexandru, Neus Altet, Korkut Avsar , et al. · 2015

Drug-resistant Mycobacterium tuberculosis is challenging elimination of tuberculosis (TB). We evaluated risk factors for TB and levels of second-line drug resistance in M. tuberculosis in patients in Europe with multidrug-resistant (MDR) T…

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