Susana Machado
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View article: Clinical Implementation of an Adapted Infection Risk Screening Tool Following Nurse-Led Haemodialysis Vascular Access Consultation
Clinical Implementation of an Adapted Infection Risk Screening Tool Following Nurse-Led Haemodialysis Vascular Access Consultation Open
Background: Healthcare-associated infection drives morbidity and unplanned hospital use in haemodialysis. We aimed to determine whether an adapted British Renal Society Infection Risk Screening Tool, applied during a nurse-led vascular acc…
View article: Intestinal mucosal alterations parallel central demyelination and remyelination: insights into the gut-brain axis in the cuprizone model of multiple sclerosis
Intestinal mucosal alterations parallel central demyelination and remyelination: insights into the gut-brain axis in the cuprizone model of multiple sclerosis Open
Background The gut-brain axis has been increasingly recognized as a critical factor in Multiple Sclerosis (MS) pathophysiology. While its role in demyelination is well documented, gut-brain axis involvement during remyelination remains lar…
View article: Modulation of Immune Cells by Aspirin During Pregnancy
Modulation of Immune Cells by Aspirin During Pregnancy Open
Pregnancy requires precise maternal immune adaptation to support fetal development while maintaining defense against external threats. Disruption of this balance can result in complications such as preeclampsia (PE), a major cause of mater…
View article: Clinical Frailty Scale and Charlson Comorbidity Index as predictors of hospitalization and mortality risk after kidney transplant failure
Clinical Frailty Scale and Charlson Comorbidity Index as predictors of hospitalization and mortality risk after kidney transplant failure Open
In this cohort, frailty defined by CFS was associated with hospitalization and mortality, while comorbidity burden evaluated by CCI was strongly related to mortality. These tools may help personalize the care of patients with a failing gra…
View article: Clinical Frailty Scale and Charlson Comorbidity Index as predictors of hospitalization and mortality risk after kidney transplant failure
Clinical Frailty Scale and Charlson Comorbidity Index as predictors of hospitalization and mortality risk after kidney transplant failure Open
Introduction and objectives: Kidney transplant (KT) recipients who experience graft failure and return to dialysis face a higher risk of adverse outcomes. This study aimed to identify risk factors for hospitalization and mortality two year…
View article: Prolonging calcineurin inhibitor therapy post kidney allograft failure: a prospective study
Prolonging calcineurin inhibitor therapy post kidney allograft failure: a prospective study Open
Prolonged CNI therapy for six months postallograft loss did not prevent HLA sensitization but reduced the incidence of GIS and preserved residual kidney function without increasing hospitalization or mortality.
View article: #3036 The influence of first renal graft on second graft rejection and survival: the importance of revisiting histocompatibility and clinical outcomes
#3036 The influence of first renal graft on second graft rejection and survival: the importance of revisiting histocompatibility and clinical outcomes Open
Background and Aims Kidney retransplantation confers a robust survival benefit over dialysis and recent data has shown similar outcomes to first kidney transplant. The number of HLA mismatches is an important predictor of graft loss and se…
View article: Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases
Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases Open
Mounting evidence progressively appreciates the vital interplay between immunity and metabolism in a wide array of immunometabolic chronic disorders, both autoimmune and non-autoimmune mediated. The immune system regulates the functioning …
View article: Challenges in the Management of the Patient with a Failing Kidney Graft: A Narrative Review
Challenges in the Management of the Patient with a Failing Kidney Graft: A Narrative Review Open
Patients with a failed kidney allograft have steadily increase in recent years and returning to dialysis after graft loss is one of the most difficult transitions for chronic kidney disease patients and their assistant physicians. The mana…
View article: Strategies to Overcome HLA Sensitization and Improve Access to Retransplantation after Kidney Graft Loss
Strategies to Overcome HLA Sensitization and Improve Access to Retransplantation after Kidney Graft Loss Open
An increasing number of patients waitlisted for kidney transplantation have a previously failed graft. Retransplantation provides a significant improvement in morbidity, mortality, and quality of life when compared to dialysis. However, HL…
View article: New perspectives on the approach to patients with atypical Hemolytic Uremic Syndrome candidates for renal transplantation
New perspectives on the approach to patients with atypical Hemolytic Uremic Syndrome candidates for renal transplantation Open
Atypical hemolytic uremic syndrome (aHUS) is one of the most challenging diseases for a nephrologist, with high rates of progression to end- -stage kidney disease (ESKD) and post-transplant recurrence. Complement dysregulation has been fou…
View article: Geohazards in Iberoamerica. The role of the Iberoamerican Geological Surveys and Mining Surveys (ASGMI)
Geohazards in Iberoamerica. The role of the Iberoamerican Geological Surveys and Mining Surveys (ASGMI) Open
The geological context determines that Iberoamerica is one of the territories of the world most exposed to disasters derived from active geological processes. As far as the main geohazards which threaten the Iberoamerican countries are con…
View article: P1501KIDNEY FAILURE AND BRAIN FUNCTION DECLINE
P1501KIDNEY FAILURE AND BRAIN FUNCTION DECLINE Open
Background and Aims: Chronic kidney disease (CKD) and cognitive impairment (CI) are two major health problems in an aging population, and both carry out negative prognostic implications. Prevalence in general population appears to be aroun…
View article: Incidence, prevalence and crude survival of patients starting dialysis in Portugal (2010–16): analysis of the National Health System individual registry
Incidence, prevalence and crude survival of patients starting dialysis in Portugal (2010–16): analysis of the National Health System individual registry Open
Background The Portuguese Society of Nephrology (PSN) reported that Portugal has one of the highest incidences of dialysis in Europe. However, this claim was based on aggregated data supplied by dialysis providers, hampering comparisons be…
View article: A Single Cutaneous Ulcer in a Healthy Adolescent
A Single Cutaneous Ulcer in a Healthy Adolescent Open
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View article: Planning ESKD treatment: a plea for a stepwise person-centered approach including conservative care
Planning ESKD treatment: a plea for a stepwise person-centered approach including conservative care Open
A paradigm shift in the treatment of end-stage kidney disease (ESKD) is urgently needed.New ESKD policies should include integrated and person-centered care that focuses on the individual's preferences, needs, and values for health care.Ba…
View article: PITYRIASIS LICHENOIDES CHRONICA IN A CHILD
PITYRIASIS LICHENOIDES CHRONICA IN A CHILD Open
Introdução: A pitíríase liquenóide (PL) é uma dermatose pouco comum e apresenta duas variantes major: a pitiríase liquenóide e varioliforme aguda (PLEVA) e a pitiríase líquenóide crónica (PLC). A sua classificação baseia-se essencialmente …
View article: Infantile bullous pemphigoid with “string of pearls sign”
Infantile bullous pemphigoid with “string of pearls sign” Open
Bullous pemphigoid (BP) is an immune mediated bullous disease that is manifested by urticarial plaques with superimposed subepidermal blisters and significant pruritus. It is generally found in the elderly, but is rare in the pediatric pop…
View article: Infantile myofibromatosis – a clinical and pathological diagnostic challenge
Infantile myofibromatosis – a clinical and pathological diagnostic challenge Open
Infantile myofibromatosis is a rare disorder of fibroblastic/myofibroblastic proliferation and represents the most frequent type of mesenchymal tumor in the neonatal period and primary infancy.Three clinical types have been described: soli…
View article: Acute liver failure due to primary amyloidosis in a nephrotic syndrome: a swiftly progressive course
Acute liver failure due to primary amyloidosis in a nephrotic syndrome: a swiftly progressive course Open
AL amyloidosis is a clonal plasma cell proliferative disorder characterised by extracellular tissue deposits of insoluble fibrils derived from κ or λ immunoglobulin light chains. The most common organs affected by AL amyloidosis are the ki…