Sofia Brunet
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View article: SARS-CoV-2 replicates and displays oncolytic properties in clear cell and papillary renal cell carcinoma
SARS-CoV-2 replicates and displays oncolytic properties in clear cell and papillary renal cell carcinoma Open
The SARS-CoV-2 virus is currently causing a global pandemic. Infection may result in a systemic disease called COVID-19, affecting primarily the respiratory tract. Often the gastrointestinal tract and kidneys also become involved. Angioten…
View article: Optimization of cerebrospinal fluid microbial metagenomic sequencing diagnostics
Optimization of cerebrospinal fluid microbial metagenomic sequencing diagnostics Open
Background Infection in the central nervous system is a severe condition associated with high morbidity and mortality. Despite ample testing, the majority of encephalitis and meningitis cases remain undiagnosed. Metagenomic sequencing of c…
View article: Inosine Triphosphate Pyrophosphatase Dephosphorylates Ribavirin Triphosphate and Reduced Enzymatic Activity Potentiates Mutagenesis in Hepatitis C Virus
Inosine Triphosphate Pyrophosphatase Dephosphorylates Ribavirin Triphosphate and Reduced Enzymatic Activity Potentiates Mutagenesis in Hepatitis C Virus Open
This study highlights the multiple modes of action of ribavirin, including depletion of intracellular GTP and increased hepatitis C virus mutagenesis. In cell culture, reduced ITP pyrophosphatase (ITPase) enzyme activity affected the intra…