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View article: Characterization of <scp>WAC</scp> interactions with <scp>R2TP</scp> and <scp>TTT</scp> chaperone complexes linking glucose and glutamine availability to <scp>mTORC1</scp> activity
Characterization of <span>WAC</span> interactions with <span>R2TP</span> and <span>TTT</span> chaperone complexes linking glucose and glutamine availability to <span>mTORC1</span> activity Open
TELO2‐TTI1‐TTI2 (TTT) and R2TP are multi‐subunit chaperones that cooperate with HSP90 to assemble matured complexes of the PIKK family of kinases, including mTOR complex 1 (mTORC1). WAC, a protein previously implicated in transcription, H2…
View article: CryoEM of RUVBL1–RUVBL2–ZNHIT2, a complex that interacts with pre-mRNA-processing-splicing factor 8
CryoEM of RUVBL1–RUVBL2–ZNHIT2, a complex that interacts with pre-mRNA-processing-splicing factor 8 Open
Biogenesis of the U5 small nuclear ribonucleoprotein (snRNP) is an essential and highly regulated process. In particular, PRPF8, one of U5 snRNP main components, requires HSP90 working in concert with R2TP, a cochaperone complex containing…
View article: The Bacterial Mucosal Immunotherapy MV130 Protects Against SARS-CoV-2 Infection and Improves COVID-19 Vaccines Immunogenicity
The Bacterial Mucosal Immunotherapy MV130 Protects Against SARS-CoV-2 Infection and Improves COVID-19 Vaccines Immunogenicity Open
COVID-19-specific vaccines are efficient prophylactic weapons against SARS-CoV-2 virus. However, boosting innate responses may represent an innovative way to immediately fight future emerging viral infections or boost vaccines. MV130 is a …
View article: BMP-7 attenuates left ventricular remodelling under pressure overload and facilitates reverse remodelling and functional recovery
BMP-7 attenuates left ventricular remodelling under pressure overload and facilitates reverse remodelling and functional recovery Open
The disequilibrium between BMP-7 and TGF-β signals plays a relevant role in the LV remodelling response to haemodynamic stress in TAC mice and AS patients. Our observations may provide new important insights aimed at developing novel thera…
View article: Protein Kinase C ζ Interacts with a Novel Binding Region of Gαq to Act as a Functional Effector
Protein Kinase C ζ Interacts with a Novel Binding Region of Gαq to Act as a Functional Effector Open
Heterotrimeric G proteins play an essential role in the initiation of G protein-coupled receptor (GPCR) signaling through specific interactions with a variety of cellular effectors. We have recently reported that GPCR activation promotes a…