Sofia Corella
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View article: Pharmacologic reversal of advanced Alzheimer’s disease in mice and identification of potential therapeutic nodes in human brain
Pharmacologic reversal of advanced Alzheimer’s disease in mice and identification of potential therapeutic nodes in human brain Open
Alzheimer's disease (AD) is traditionally considered irreversible. Here, however, we provide proof of principle for therapeutic reversibility of advanced AD. In advanced disease amyloid-driven 5xFAD mice, treatment with P7C3-A20, which res…
View article: Reducing tau acetylation rescues cognitive deficits in a mouse model of traumatic brain injury‐induced acceleration of Alzheimer’s disease
Reducing tau acetylation rescues cognitive deficits in a mouse model of traumatic brain injury‐induced acceleration of Alzheimer’s disease Open
Background TBI is the 3rd greatest risk factor for developing AD, behind genetics and aging. TBI is associated with a 3‐4 year earlier onset of cognitive impairment, and increased cortical thinning and amyloid plaques in people with AD. Th…
View article: Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model
Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model Open
Traumatic brain injury (TBI) is the leading cause of death in young people and can cause cognitive and motor dysfunction and disruptions in functional connectivity between brain regions. In human TBI patients and rodent models of TBI, func…
View article: Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model
Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model Open
Traumatic brain injury (TBI) is the leading cause of death in young people and can cause cognitive and motor dysfunction and disruptions in functional connectivity between brain regions. In human TBI patients and rodent models of TBI, func…