Sofia Dembski
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View article: <scp> 7T <sup>19</sup> F </scp> / <scp> <sup>1</sup> H MRI </scp> with perfluorocarbon‐labeled immune cells in pigs: Pilot results with a dedicated twin‐array system with <scp>pTX</scp> support
<span> 7T <sup>19</sup> F </span> / <span> <sup>1</sup> H MRI </span> with perfluorocarbon‐labeled immune cells in pigs: Pilot results with a dedicated twin‐array system with <span>pTX</span> support Open
Purpose Cardiac inflammation plays a key role in many diseases. However, its underlying mechanisms and progression remain poorly understood. Using an ultra‐high field (UHF) may increase the sensitivity of MRI of inflammatory processes with…
View article: P07.07.A A NEW SOL-GEL DERIVED DRUG DELIVERY SYSTEM FOR THE LOCAL TREATMENT OF GLIOBLASTOMA BASED ON FULLY RESORBABLE RENACER FIBER FLEECES
P07.07.A A NEW SOL-GEL DERIVED DRUG DELIVERY SYSTEM FOR THE LOCAL TREATMENT OF GLIOBLASTOMA BASED ON FULLY RESORBABLE RENACER FIBER FLEECES Open
BACKGROUND Glioblastoma (GBM) remains difficult to treat due to its invasive growth, molecular heterogeneity, and therapy resistance. Tumor recurrence at the resection margins represents a key clinical challenge, as standard postoperative …
View article: High concentrations of Printex 90 carbon black ultrafine particles disturb the epithelial barrier in human primary respiratory mucosa models
High concentrations of Printex 90 carbon black ultrafine particles disturb the epithelial barrier in human primary respiratory mucosa models Open
Airborne pollutants harm human health, but the mechanisms involved remain unclear. Impaired epithelial barrier function is, as in respiratory diseases, one possible pathomechanism. To investigate this, carbon black (CB) as a model for ultr…
View article: Smart thin porous calcium phosphate coatings for local antibiotic delivery
Smart thin porous calcium phosphate coatings for local antibiotic delivery Open
Objective Implant failure after arthroplasty, primarily due to aseptic loosening or periprosthetic joint infection, remains a significant clinical problem. Bioactive ceramic coatings, such as β-tricalcium phosphate (β-TCP), enhance osseoin…
View article: Smart Thin Porous Calcium Phosphate Coatings for Local Antibiotic Delivery
Smart Thin Porous Calcium Phosphate Coatings for Local Antibiotic Delivery Open
Implant failure after arthroplasty due to aseptic loosening or periprosthetic joint infections remains a serious clinical challenge. To avoid these complications, bioactive ceramic coatings e.g., β-tricalcium phosphate (β-TCP) can be used …
View article: Biodegradable, Antibacterial <scp>TCP</scp> Implant Coatings With Magnesium Phosphate‐Based Supraparticles
Biodegradable, Antibacterial <span>TCP</span> Implant Coatings With Magnesium Phosphate‐Based Supraparticles Open
This work highlights the potential of porous, bioactive coatings to advance implant technology and address critical clinical challenges. A key issue in implant coatings is to achieve the balance between infection prevention and successful …
View article: Cu‐doped magnesium phosphate supraparticles: A promising material for bone tissue regeneration
Cu‐doped magnesium phosphate supraparticles: A promising material for bone tissue regeneration Open
Calcium phosphate (CaP) minerals have been widely studied as bone substitutes due to their excellent osteoconductivity and biocompatibility. However, their limited biodegradability remains a challenge. Magnesium phosphates (MgPs) are promi…
View article: Suspension-Sprayed Calcium Phosphate Coatings with Antibacterial Properties
Suspension-Sprayed Calcium Phosphate Coatings with Antibacterial Properties Open
Prosthesis loosening due to lack of osteointegration between an implant and surrounding bone tissue is one of the most common causes of implant failure. Further, bacterial contamination and biofilm formation onto implants represent a serio…
View article: Comparative Studies of the Structural and Physicochemical Properties of the First Fullerene Derivative FD-C60 (Fullerenol) and Second Fullerene Derivate SD-C60 (3HFWC)
Comparative Studies of the Structural and Physicochemical Properties of the First Fullerene Derivative FD-C60 (Fullerenol) and Second Fullerene Derivate SD-C60 (3HFWC) Open
In order to maximally reduce the toxicity of fullerenol (the first derivative of C60, FD-C60), and increase its biomedical efficiency, the second derivative SD-C60 (3HFWC, Hyper-Harmonized Hydroxylated Fullerene Water Complex) was created.…
View article: Cu-doped calcium phosphate supraparticles for bone tissue regeneration
Cu-doped calcium phosphate supraparticles for bone tissue regeneration Open
Antibacterial, biodegradable spray dried Cu-doped CaP supraparticles with high cell viability show great potential as bone substitute materials.
View article: Comparative Studies of Structural and Physicochemical Properties of the First Fullerene Derivative FD‐C60 (Fullerenol) and the Second Fullerene Derivate SD‐C60 (3HFWC)
Comparative Studies of Structural and Physicochemical Properties of the First Fullerene Derivative FD‐C60 (Fullerenol) and the Second Fullerene Derivate SD‐C60 (3HFWC) Open
(1) Background: Since fullerene C60 is insoluble in water and is toxic, it is not applicable in biomedicine and cosmetics. For this reason, the first derivative FD-C60 (fullerenol) was synthesized, which solved the problem of solubility in…
View article: Assessment of the Impact of Nanowarming on Microstructure of Cryopreserved Fibroblast-Containing 3D Tissue Models Using Mueller Polarimetry
Assessment of the Impact of Nanowarming on Microstructure of Cryopreserved Fibroblast-Containing 3D Tissue Models Using Mueller Polarimetry Open
We studied the impact of two different thawing mechanisms on the microstructure of defrosted cryopreserved 3D tissue models using transmission Mueller microscopy and a statistical analysis of polarimetric images of thin histological sectio…
View article: Biomimetic Connection of Transcutaneous Implants with Skin
Biomimetic Connection of Transcutaneous Implants with Skin Open
Bacterial infection is a crucial complication in implant restoration, in particular in permanent skin‐penetrating implants. Therein, the resulting gap between transcutaneous implant and skin represents a permanent infection risk, limiting …
View article: Synthesis and Characterization of Ceramide-Containing Liposomes as Membrane Models for Different T Cell Subpopulations
Synthesis and Characterization of Ceramide-Containing Liposomes as Membrane Models for Different T Cell Subpopulations Open
A fine balance of regulatory (Treg) and conventional CD4+ T cells (Tconv) is required to prevent harmful immune responses, while at the same time ensuring the development of protective immunity against pathogens. As for many cellular proce…
View article: Preparation of Phosphorescent Eu<sup>2+</sup>, Dy<sup>3+</sup>‐Doped Strontium Aluminate Nanoparticles by Laser Vaporization for the Modification of Therapeutic Contact Lenses
Preparation of Phosphorescent Eu<sup>2+</sup>, Dy<sup>3+</sup>‐Doped Strontium Aluminate Nanoparticles by Laser Vaporization for the Modification of Therapeutic Contact Lenses Open
Biologically, effectively regulated light with a wavelength of about 485 nm can support physiological processes in the body and has a positive impact on the human sleep–wake rhythm. However, the application of common light therapy devices …
View article: Sol-Gel-Derived Fibers Based on Amorphous α-Hydroxy-Carboxylate-Modified Titanium(IV) Oxide as a 3-Dimensional Scaffold
Sol-Gel-Derived Fibers Based on Amorphous α-Hydroxy-Carboxylate-Modified Titanium(IV) Oxide as a 3-Dimensional Scaffold Open
The development of novel fibrous biomaterials and further processing of medical devices is still challenging. For instance, titanium(IV) oxide is a well-established biocompatible material, and the synthesis of TiOx particles and coatings v…
View article: Evaluation of genotoxicity and cytotoxicity of toner particle aerosols in a 3D air-liquid interface with primary cells of the respiratory epithelium
Evaluation of genotoxicity and cytotoxicity of toner particle aerosols in a 3D air-liquid interface with primary cells of the respiratory epithelium Open
According to the 3R principle to avoid animal experiments, models with a high in vivo correlation are currently being sought. The air-liquid interface (ALI) per se, but especially in combination with primary cells, represents a promising, …
View article: Assessment of Human Health Risks Posed by Nano-and Microplastics Is Currently Not Feasible
Assessment of Human Health Risks Posed by Nano-and Microplastics Is Currently Not Feasible Open
The exposure of humans to nano-and microplastic particles (NMPs) is an issue recognized as a potential health hazard by scientists, authorities, politics, non-governmental organizations and the general public. The concentration of NMPs in …
View article: Analysis of tissue microstructure with Mueller microscopy: logarithmic decomposition and Monte Carlo modeling
Analysis of tissue microstructure with Mueller microscopy: logarithmic decomposition and Monte Carlo modeling Open
Significance: Definitive diagnostics of many diseases is based on the histological analysis of thin tissue cuts with optical white light microscopy. Extra information on tissue structural properties obtained with polarized light would help…
View article: The Radiosensitizing Effect of Zinc Oxide Nanoparticles in Sub-Cytotoxic Dosing Is Associated with Oxidative Stress In Vitro
The Radiosensitizing Effect of Zinc Oxide Nanoparticles in Sub-Cytotoxic Dosing Is Associated with Oxidative Stress In Vitro Open
Radioresistance is an important cause of head and neck cancer therapy failure. Zinc oxide nanoparticles (ZnO-NP) mediate tumor-selective toxic effects. The aim of this study was to evaluate the potential for radiosensitization of ZnO-NP. T…
View article: Cultivation of hMSCs in Human Plasma Prevents the Cytotoxic and Genotoxic Potential of ZnO-NP In Vitro
Cultivation of hMSCs in Human Plasma Prevents the Cytotoxic and Genotoxic Potential of ZnO-NP In Vitro Open
Zinc oxide nanoparticles (ZnO-NPs) are commonly used for industrial applications. Consequently, there is increasing exposure of humans to them. The in vitro analysis of cytotoxicity and genotoxicity is commonly performed under standard cel…
View article: Digital histology with Mueller microscopy: how to mitigate an impact of tissue cut thickness fluctuations
Digital histology with Mueller microscopy: how to mitigate an impact of tissue cut thickness fluctuations Open
Mueller microscopy studies of fixed unstained histological cuts of human skin models were combined with an analysis of experimental data within the framework of differential Mueller matrix (MM) formalism. A custom-built Mueller polarimetri…
View article: Calcium fluoride based multifunctional nanoparticles for multimodal imaging
Calcium fluoride based multifunctional nanoparticles for multimodal imaging Open
New multifunctional nanoparticles (NPs) that can be used as contrast agents (CA) in different imaging techniques, such as photoluminescence (PL) microscopy and magnetic resonance imaging (MRI), open new possibilities for medical imaging, e…
View article: Synthesis and Characterization of NIR Dye-Doped Nanoparticles forin Vivo Tumor Diagnostics
Synthesis and Characterization of NIR Dye-Doped Nanoparticles forin Vivo Tumor Diagnostics Open
Nanoparticles (NPs) are promising tools for a wide spectrum of biological and medical applications. They can be used as carrier and delivery systems for active agents such as biomolecules, dyes and a wide range of sensitive substances and …
View article: Multifunctional Nanoparticles for Medical Applications
Multifunctional Nanoparticles for Medical Applications Open
Paper NDDTE 102, 2 S.
View article: Surfactant free superparamagnetic iron oxide nanoparticles for stable ferrofluids in physiological solutions
Surfactant free superparamagnetic iron oxide nanoparticles for stable ferrofluids in physiological solutions Open
Ferrofluids of superparamagnetic Fe3O4 nanoparticles with “patchy” silica shell are stable over a wide pH range and in physiological solutions.