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View article: Endogenous SNAP-Tagging of Munc13-1 for Monitoring Synapse Nanoarchitecture
Endogenous SNAP-Tagging of Munc13-1 for Monitoring Synapse Nanoarchitecture Open
Synaptic function is governed by highly regulated protein machineries, whose abundance and spatial localization change continually. Studies to determine dynamic changes in synaptic protein nanoarchitecture typically rely on immunolabeling …
View article: Highly Specific Miniaturized Fluorescent Monoacylglycerol Lipase Probes Enable Translational Research
Highly Specific Miniaturized Fluorescent Monoacylglycerol Lipase Probes Enable Translational Research Open
Monoacylglycerol lipase (MAGL) is the pivotal catabolic enzyme responsible for signal termination in the endocannabinoid system. Inhibition of MAGL offers unique advantages over the direct activation of cannabinoid receptors in treating ca…
View article: A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase
A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase Open
Monoacylglycerol lipase (MAGL) is a key enzyme for signal termination in the endocannabinoid system (ECS). MAGL inhibition results in indirect activation of the cannabinoid receptors, which offers unique advantages for the treatment of, e.…
View article: A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase
A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase Open
Monoacylglycerol lipase (MAGL) is a key enzyme for signal termination in the endocannabinoid system (ECS). MAGL inhibition results in indirect activation of the cannabinoid receptors, which offers unique advantages for the treatment of, e.…
View article: Endogenous SNAP-tagging of Munc13-1 for monitoring synapse nanoarchitecture
Endogenous SNAP-tagging of Munc13-1 for monitoring synapse nanoarchitecture Open
Synaptic function is governed by highly regulated protein machineries, whose abundance and spatial localization change continually. Studies to determine the dynamic changes in synaptic proteins nanoarchitecture typically rely on immunolabe…
View article: Highly adaptable deep-learning platform for automated detection and analysis of vesicle exocytosis
Highly adaptable deep-learning platform for automated detection and analysis of vesicle exocytosis Open
Vesicle exocytosis is a fundamental component of intercellular communication, in all organisms. It has been studied for decades, using various imaging tools. Nevertheless, exocytosis research is still limited by the lack of reliable automa…
View article: An intellectual-disability-associated mutation of the transcriptional regulator NACC1 impairs glutamatergic neurotransmission
An intellectual-disability-associated mutation of the transcriptional regulator NACC1 impairs glutamatergic neurotransmission Open
Advances in genome sequencing technologies have favored the identification of rare de novo mutations linked to neurological disorders in humans. Recently, a de novo autosomal dominant mutation in NACC1 was identified (NM_052876.3: c.892C &…
View article: A fluorescent nanosensor paint detects dopamine release at axonal varicosities with high spatiotemporal resolution
A fluorescent nanosensor paint detects dopamine release at axonal varicosities with high spatiotemporal resolution Open
Significance The neurotransmitter dopamine controls normal behavior and dopaminergic dysfunction is prevalent in multiple brain diseases. To reach a detailed understanding of how dopamine release and signaling are regulated at the subcellu…
View article: A fluorescent nanosensor paint reveals the heterogeneity of dopamine release from neurons at individual release sites
A fluorescent nanosensor paint reveals the heterogeneity of dopamine release from neurons at individual release sites Open
The neurotransmitter dopamine is released from discrete axonal structures called varicosities. Its release is essential in behaviour and is critically implicated in prevalent neuropsychiatric diseases. Existing dopamine detection methods a…
View article: Imaging of Monoamine Neurotransmitters with Fluorescent Nanoscale Sensors
Imaging of Monoamine Neurotransmitters with Fluorescent Nanoscale Sensors Open
Cells use biomolecules to convey information. For instance, neurons communicate by releasing chemicals called neurotransmitters, including several monoamines. The information transmitted by neurons is, in part, coded in the type and amount…