Isabel Correia
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View article: Liposomal formulations of novel metal-based complexes exhibiting high antitumor activity against melanoma
Liposomal formulations of novel metal-based complexes exhibiting high antitumor activity against melanoma Open
Melanoma is the most aggressive skin cancer and, despite therapeutic advances in recent years, it continues to be associated with the highest mortality rates. Thus, the development of more effective and safer treatment options remain imper…
View article: Anti-tumor and cellular mechanisms of HfIV tetra-(8-hydroxyquinolinato) complexes
Anti-tumor and cellular mechanisms of HfIV tetra-(8-hydroxyquinolinato) complexes Open
Three 8-hydroxyquinoline-stabilized hafnium complexes, [HfIV(oxinate)4], were synthesized with good aqueous stability and solubility by reacting HfIVCl4 with 8-hydroxyquinoline (HL1), 2-methyl-8-hydroxyquinoline (HL2) and 5-chloro-8-hydrox…
View article: Novel 8-Hydroxyquinoline-Derived V(IV)O, Ni(II), and Fe(III) Complexes: Synthesis, Characterization, and In Vitro Cytotoxicity Against Tumor Cells
Novel 8-Hydroxyquinoline-Derived V(IV)O, Ni(II), and Fe(III) Complexes: Synthesis, Characterization, and In Vitro Cytotoxicity Against Tumor Cells Open
We report the synthesis and characterization of five novel metal complexes. Three of them are vanadium complexes with the general formula [VO(Ln)2], where Ln are Schiff bases derived from the condensation of 2-carbaldehyde-8-hydroxyquinoli…
View article: Synthesis, crystal structure, computational and solution studies of a new phosphotetradecavanadate salt. Assessment of its effect on U87 glioblastoma cells
Synthesis, crystal structure, computational and solution studies of a new phosphotetradecavanadate salt. Assessment of its effect on U87 glioblastoma cells Open
The new benzylammonium (C7H10N) salt of the phosphotetradecavanadate (PV14) anion PV14O429-, (C7H10N)6[H3PV14O42]∙7H2O (1), is synthesized under mild conditions and characterized by a combination of physicochemical techniques such as Fouri…
View article: Synthesis and X-ray structure analysis of cytotoxic 2-picolylamino-type Hf<sup>IV</sup>-bis-chelated complexes
Synthesis and X-ray structure analysis of cytotoxic 2-picolylamino-type Hf<sup>IV</sup>-bis-chelated complexes Open
Phenolato Hf IV bis-chelates demonstrate potent anti-tumor activity, good aqueous stability, and can induce generation of hydroxyl radicals. They can lead to mitochondrial damage and are hallmarked by inducing early apoptosis of tumor cell…
View article: A critical analysis of the potential of iron heterobimetallic complexes in anticancer research
A critical analysis of the potential of iron heterobimetallic complexes in anticancer research Open
Due to their diverse chemical properties and high ability to interact with biological molecules and cellular processes, transition metal-based compounds have emerged as promising candidates for cancer therapy. Iron complexes are among them…
View article: Cellular targets of cytotoxic copper phenanthroline complexes: a multimodal imaging quantitative approach in single PC3 cells
Cellular targets of cytotoxic copper phenanthroline complexes: a multimodal imaging quantitative approach in single PC3 cells Open
Metal complexes are emerging as promising alternatives to traditional platinum-based cancer treatments, offering reduced side effects. However, understanding their cellular uptake and distribution and quantifying their presence at the sing…
View article: A review of hydrazide-hydrazone metal complexes’ antitumor potential
A review of hydrazide-hydrazone metal complexes’ antitumor potential Open
Cancer inflicts a tremendous burden on modern society, and more effective and selective treatments need to be developed. Metallodrugs have been extensively explored as alternatives to current chemotherapeutic regimens that suffer from shor…
View article: Facing diseases caused by trypanosomatid parasites: rational design of multifunctional oxidovanadium(IV) complexes with bioactive ligands
Facing diseases caused by trypanosomatid parasites: rational design of multifunctional oxidovanadium(IV) complexes with bioactive ligands Open
Searching for new prospective drugs against Chagas disease (American trypanosomiasis) and Leishmaniasis, a series of five heteroleptic vanadium compounds, [V IV O(L-H)(mpo)], where L are 8-hydroxyquinoline derivatives and mpo is 2-mercapto…
View article: Vanadium Chemistry in the 21st Century
Vanadium Chemistry in the 21st Century Open
Guest Editors Armando J. L. Pombeiro, Manas Sutradhar and Isabel Correia introduce the New Journal of Chemistry “Vanadium Chemistry in the 21st Century” themed collection.
View article: CCDC 2251166: Experimental Crystal Structure Determination
CCDC 2251166: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2251165: Experimental Crystal Structure Determination
CCDC 2251165: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2251162: Experimental Crystal Structure Determination
CCDC 2251162: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2251163: Experimental Crystal Structure Determination
CCDC 2251163: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2251164: Experimental Crystal Structure Determination
CCDC 2251164: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2251161: Experimental Crystal Structure Determination
CCDC 2251161: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Cu(II) and Zn(II) Complexes of New 8-Hydroxyquinoline Schiff Bases: Investigating Their Structure, Solution Speciation, and Anticancer Potential
Cu(II) and Zn(II) Complexes of New 8-Hydroxyquinoline Schiff Bases: Investigating Their Structure, Solution Speciation, and Anticancer Potential Open
We report the synthesis and characterization of three novel Schiff bases (L1-L3) derived from the condensation of 2-carbaldehyde-8-hydroxyquinoline with amines containing morpholine or piperidine moieties. These were reacted with CuCl2 and…
View article: CCDC 2004342: Experimental Crystal Structure Determination
CCDC 2004342: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2004343: Experimental Crystal Structure Determination
CCDC 2004343: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2004341: Experimental Crystal Structure Determination
CCDC 2004341: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: A Series of Non-Oxido V<sup>IV</sup>Complexes of Dibasic ONS Donor Ligands: Solution Stability, Chemical Transformations, Protein Interactions, and Antiproliferative Activity
A Series of Non-Oxido V<sup>IV</sup>Complexes of Dibasic ONS Donor Ligands: Solution Stability, Chemical Transformations, Protein Interactions, and Antiproliferative Activity Open
A series of mononuclear non-oxido vanadium(IV) complexes, [VIV(L1-4)2] (1-4), featuring tridentate bi-negative ONS chelating S-alkyl/aryl-substituted dithiocarbazate ligands H2L1-4, are reported. All the synthesized non-oxido VIV compounds…
View article: Grand challenges in bioinorganic chemistry
Grand challenges in bioinorganic chemistry Open
SPECIALTY GRAND CHALLENGE article Front. Chem. Biol., 12 April 2023Sec. Bioinorganic Chemistry Volume 2 - 2023 | https://doi.org/10.3389/fchbi.2023.1165773
View article: Promising anticancer agents based on 8-hydroxyquinoline hydrazone copper(II) complexes
Promising anticancer agents based on 8-hydroxyquinoline hydrazone copper(II) complexes Open
We report the synthesis and characterization of a group of benzoylhydrazones (L n ) derived from 2-carbaldehyde-8-hydroxyquinoline and benzylhydrazides containing distinct para substituents (R = H, Cl, F, CH 3 , OCH 3 , OH and NH 2 , for L…