Sofia Laforest
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View article: Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertension
Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertension Open
Background and Purpose The contribution of obesity to pulmonary arterial hypertension (PAH) pathophysiology remains poorly understood. Adipose tissue synthesises estrogens via cytochrome P450 (CYP) 19A1 (aromatase), whereas circulating est…
View article: Luteal phase oral dexamethasone administration alters the endometrial steroid milieu
Luteal phase oral dexamethasone administration alters the endometrial steroid milieu Open
We previously published the DexFEM trial, which showed that in women with heavy menstrual bleeding (HMB), oral dexamethasone reduces menstrual blood loss. Here, we report a pharmacodynamic analysis exploring the likely mechanism for this e…
View article: Increased Adipose Tissue Indices of Androgen Catabolism and Aromatization in Women With Metabolic Dysfunction
Increased Adipose Tissue Indices of Androgen Catabolism and Aromatization in Women With Metabolic Dysfunction Open
Context Body fat distribution is a risk factor for obesity-associated comorbidities, and adipose tissue dysfunction plays a role in this association. In humans, there is a sex difference in body fat distribution, and steroid hormones are k…
View article: Increased adipose tissue indices of androgen catabolism and aromatization in women with metabolic dysfunction
Increased adipose tissue indices of androgen catabolism and aromatization in women with metabolic dysfunction Open
Background Body fat distribution is a risk factor for obesity-associated comorbidities, and adipose tissue dysfunction plays a role in this association. In humans, there is a sex difference in body fat distribution, and steroid hormones ar…
View article: Differential effects of EPA and DHA on plasma and adipose tissue lipid mediators: the ComparED study
Differential effects of EPA and DHA on plasma and adipose tissue lipid mediators: the ComparED study Open
Oxylipins and endocannabinoids (eCBs) both belong to superclasses of lipid mediators with potent inflammation modulatory activities. The adipose tissue (AT) plays a key role in metabolic syndrome-related inflammation, via altered adipocyte…
View article: Estrogens and Glucocorticoids in Mammary Adipose Tissue: Relationships with Body Mass Index and Breast Cancer Features
Estrogens and Glucocorticoids in Mammary Adipose Tissue: Relationships with Body Mass Index and Breast Cancer Features Open
Context Adipose tissue is an important site for extragonadal steroid hormone biosynthesis through the expression and activity of P450 aromatase, 11β-hydroxysteroid dehydrogenase (HSD) 1, and 17β-HSDs. The contribution of steroid hormones p…