Sofia Lotti
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View article: Complex I Modulator BI4500 Reduces MASH by Limiting Oxidative Stress and Reprogramming Lipid Metabolism via AMPK in MCD Rats
Complex I Modulator BI4500 Reduces MASH by Limiting Oxidative Stress and Reprogramming Lipid Metabolism via AMPK in MCD Rats Open
Background: Metabolic-dysfunction-associated steatotic liver disease (MASLD) is a multifactorial liver disease in which mitochondrial dysfunction, oxidative stress, and inflammation play key roles in driving the progression toward metaboli…
View article: Controversies and Perspectives of Time-Qualified Dietary Interventions
Controversies and Perspectives of Time-Qualified Dietary Interventions Open
Time-qualified dietary interventions, including time-restricted eating (TRE), intermittent fasting (IF), and periodic fasting-mimicking diets (FMDs), have emerged as strategies to improve metabolic health. While preclinical studies consist…
View article: Sleep Irregularity and Short Sleep Duration Are Associated with Less Favorable Cardiometabolic Profiles in Healthy Adults: A Cross-Sectional Study
Sleep Irregularity and Short Sleep Duration Are Associated with Less Favorable Cardiometabolic Profiles in Healthy Adults: A Cross-Sectional Study Open
Background/Objectives: The aim of this study is to evaluate the relation between sleep quantity (TST), efficiency (SE) and regularity (SRI) and cardiometabolic parameters and eating habits. Methods: Seventy clinically healthy adults (74% f…
View article: Ultra-Processed Foods Consumption, Mediterranean Diet Adherence and Sociodemographic Correlates in an Italian Adult Population: The UFO Survey
Ultra-Processed Foods Consumption, Mediterranean Diet Adherence and Sociodemographic Correlates in an Italian Adult Population: The UFO Survey Open
Background: Although national surveys report increasing ultra-processed foods (UPFs) consumption, updated estimates for Italy are lacking. Given the central role of the Mediterranean Diet (MD), understanding how UPFs contribute to the cont…
View article: Enhance Adherence to the Mediterranean Diet in an Italian Academic Setting: A Workplace Health Promotion Programme
Enhance Adherence to the Mediterranean Diet in an Italian Academic Setting: A Workplace Health Promotion Programme Open
Objective Despite potential health benefits, workplace health promotion programmes still remain limited and varied. This study aimed to evaluate the effectiveness of a Mediterranean Diet (MD)‐based intervention in improving the eating habi…
View article: Effects of a Probiotic Formulation Based on SF68, Phytosterols, and 6S‐5‐Methyltetrahydrofolic Acid on Body Composition, Biochemical Parameters, Gut Microbiota, and Gastrointestinal and General Symptoms of Overweight/Obese Subjects: The PrObesity Study
Effects of a Probiotic Formulation Based on SF68, Phytosterols, and 6S‐5‐Methyltetrahydrofolic Acid on Body Composition, Biochemical Parameters, Gut Microbiota, and Gastrointestinal and General Symptoms of Overweight/Obese Subjects: The PrObesity Study Open
Obesity and dyslipidemia are increasingly widespread. Considering gut microbiota's (GM) role in energy balance, probiotics represent a promising non‐pharmacological approach. This study assessed a probiotic formulation (SF68 + phytosterols…
View article: High Use of Dietary Supplements and Low Adherence to the Mediterranean Diet Among Italian Adolescents: Results from the EduALI Project
High Use of Dietary Supplements and Low Adherence to the Mediterranean Diet Among Italian Adolescents: Results from the EduALI Project Open
Objective: Eating habits established during adolescence play a crucial role in shaping both current and future health status. However, adolescents today appear to be increasingly adopting poorer dietary and lifestyle habits. This study aim…
View article: From traditional to artificial intelligence-driven approaches: Revolutionizing personalized and precision nutrition in inflammatory bowel disease
From traditional to artificial intelligence-driven approaches: Revolutionizing personalized and precision nutrition in inflammatory bowel disease Open
Inflammatory bowel disease (IBD), comprising ulcerative colitis and Crohn's disease, is a chronic inflammatory condition with global prevalence and varying incidence. The IBD pathogenesis involves intricate interactions among genetic, host…
View article: The Impact of the Timing of Pasta Intake on Sleep Quality and Health Outcomes: A Protocol for a Randomized Controlled Trial
The Impact of the Timing of Pasta Intake on Sleep Quality and Health Outcomes: A Protocol for a Randomized Controlled Trial Open
Background: Pasta is a fundamental component of the Mediterranean diet and a key source of carbohydrates. Despite its nutritional benefits, misconceptions persist regarding its potential to promote weight gain, particularly when consumed a…
View article: Exploring basal metabolic rate and dietary adequacy in twin pregnancies: the VENERE study
Exploring basal metabolic rate and dietary adequacy in twin pregnancies: the VENERE study Open
This study highlights the increased energy demands and nutritional inadequacies in twin pregnancies, underscoring the need for tailored dietary guidelines and interventions.
View article: Unconventional Ingredients from the Industrial Oilseed By-Products in Dairy Goat Feeding: Effects on the Nutritional Quality of Milk and on Human Health
Unconventional Ingredients from the Industrial Oilseed By-Products in Dairy Goat Feeding: Effects on the Nutritional Quality of Milk and on Human Health Open
Oilseed by-products (Cynara cardunculus and Camelina sativa) (CCCS) are rich in bioactive compounds. This study aimed to evaluate the health effects of consuming yogurt made from goat milk fed with CCCS industrial residues in adults. In th…
View article: Effects of omega-3 fatty acids on coronary revascularization and cardiovascular events: a meta-analysis
Effects of omega-3 fatty acids on coronary revascularization and cardiovascular events: a meta-analysis Open
Aims Benefits of pharmacologic omega-3 fatty acid administration in cardiovascular prevention are controversial. Particularly, effects on coronary revascularization are unclear; also debated are specific benefits of eicosapentaenoic acid (…
View article: Knowledge, attitude and behaviours towards food sustainability in a group of Italian consumers. A cross-sectional study
Knowledge, attitude and behaviours towards food sustainability in a group of Italian consumers. A cross-sectional study Open
Sustainability is crucial for transforming the food system, addressing environmental and nutrition issues and depends on consumer perceptions and values. This cross-sectional study investigates the relationship between sustainability attit…
View article: Assessment of Mediterranean diet adherence and comparison with Italian dietary guidelines: a study of over 10,000 adults from 2019 to 2022
Assessment of Mediterranean diet adherence and comparison with Italian dietary guidelines: a study of over 10,000 adults from 2019 to 2022 Open
Despite the many well-documented benefits of the Mediterranean diet (MD), many Mediterranean countries seem to be moving away from it. The aim of this study was to investigate the MD adherence in 10,916 adults who completed the validated M…
View article: The Role of Chronotype on Body Composition, Eating Habits and Cardiometabolic Risk Parameters in a Sample of Overweight/Obese Subjects
The Role of Chronotype on Body Composition, Eating Habits and Cardiometabolic Risk Parameters in a Sample of Overweight/Obese Subjects Open
Background and objectives: In recent years, the role of chronotype in obesity has been hypothesised, as subjects with an evening chronotype showed worse eating habits. However, the results are still limited and conflicting. The aim of the …
View article: Effects of Omega-3 Fatty Acid Supplementation on Revascularization and Major Cardiovascular Events: A Systematic Review and Meta-Analysis
Effects of Omega-3 Fatty Acid Supplementation on Revascularization and Major Cardiovascular Events: A Systematic Review and Meta-Analysis Open
Background and Objectives: The clinical benefits of omega-3 fatty acid (FA) supplementation in preventing and treating cardiovascular disease remain controversial. The aim of this study was to investigate the effects of omega-3 FA administ…
View article: Meat-Based Diet Significantly Affects Risk Parameters for Colorectal Cancer: The MeaTIc Dietary Intervention Study
Meat-Based Diet Significantly Affects Risk Parameters for Colorectal Cancer: The MeaTIc Dietary Intervention Study Open
Background: Colorectal cancer (CRC) is the most commonly diagnosed cancer in Europe and the second most common cause of cancer death. The aim of the MeaTIc study was to determine the impact of three diets associated with different risks of…
View article: Effects of a Dietary Intervention with Lacto-Ovo Vegetarian and Mediterranean Diets on Apolipoproteins, Lipid Profile and Cardiovascular Risk: Results from the CARDIVEG Study
Effects of a Dietary Intervention with Lacto-Ovo Vegetarian and Mediterranean Diets on Apolipoproteins, Lipid Profile and Cardiovascular Risk: Results from the CARDIVEG Study Open
Background: Cardiovascular disease (CVD) remains the leading cause of death worldwide. Attention in recent years is turning toward the role that apolipoproteins might play as markers of CVD risk. However, to date, evidence regarding the ef…
View article: Adherence to the Mediterranean Diet and the Consumption of Its Food Groups in a Sample of over 10,000 Italian Adults
Adherence to the Mediterranean Diet and the Consumption of Its Food Groups in a Sample of over 10,000 Italian Adults Open
Adherence to the Mediterranean diet (MD) has been shown to promote health and reduce the prevalence of several chronic diseases. However, to date, more and more countries in the Mediterranean basin seem to be moving away from their traditi…
View article: Worldwide impact of COVID-19 on hospital admissions for non-ST-elevation acute coronary syndromes (NSTACS): a systematic review with meta-analysis of 553 038 cases
Worldwide impact of COVID-19 on hospital admissions for non-ST-elevation acute coronary syndromes (NSTACS): a systematic review with meta-analysis of 553 038 cases Open
Background How coronavirus disease 2019 (COVID-19) impacted non-ST-segment elevation acute coronary syndromes (NSTACS) is an object of controversial reports. Aim To systematically review studies reporting NSTACS hospitalizations during the…
View article: Circadian rhythms, gut microbiota, and diet: Possible implications for health
Circadian rhythms, gut microbiota, and diet: Possible implications for health Open
Future studies are needed to decipher the link between the circadian rhythms and specific microbial patterns in relation to different disease frameworks.
View article: Effects of the probiotic Lactiplantibacillus plantarum IMC 510® on body composition, biochemical parameters, gut microbiota composition and function, and clinical symptoms of overweight/obese subjects
Effects of the probiotic Lactiplantibacillus plantarum IMC 510® on body composition, biochemical parameters, gut microbiota composition and function, and clinical symptoms of overweight/obese subjects Open
Background and aim In recent decades, obesity prevalence has reached epidemic proportions and considering the pivotal role of gut microbiota (GM) in the regulation of energy balance, alternative non-pharmacological approaches involving pro…
View article: Adherence to the Mediterranean Diet and Ultra-Processed Foods Consumption in a Group of Italian Patients with Celiac Disease
Adherence to the Mediterranean Diet and Ultra-Processed Foods Consumption in a Group of Italian Patients with Celiac Disease Open
Evidence on the consumption of ultra-processed foods (UPF) in adults with celiac disease (CD) and its impact on Mediterranean Diet (MD) adherence is still limited. Our aim was to determine UPF consumption and its relationship with MD adher…
View article: Association between Psychological Disorders, Mediterranean Diet, and Chronotype in a Group of Italian Adults
Association between Psychological Disorders, Mediterranean Diet, and Chronotype in a Group of Italian Adults Open
Mental health conditions are a significant contributor to the global burden of disease. The aim of this study was to explore the association between psychological disorders, Mediterranean diet (MD), and chronotype. A total of 344 participa…
View article: Ageing and Low-Level Chronic Inflammation: The Role of the Biological Clock
Ageing and Low-Level Chronic Inflammation: The Role of the Biological Clock Open
Ageing is a multifactorial physiological manifestation that occurs inexorably and gradually in all forms of life. This process is linked to the decay of homeostasis due to the progressive decrease in the reparative and regenerative capacit…
View article: Association between chronotype, sleep pattern, and eating behaviours in a group of Italian adults
Association between chronotype, sleep pattern, and eating behaviours in a group of Italian adults Open
A cross-sectional study was conducted to assess the possible relationship between chronotype, sleeping, and eating patterns in 74 Italian adults (71.6% women). Based on Morningness-Eveningness Questionnare (MEQ) score, participants were cl…
View article: Consumption of Ultra-Processed Foods Is Inversely Associated with Adherence to the Mediterranean Diet: A Cross-Sectional Study
Consumption of Ultra-Processed Foods Is Inversely Associated with Adherence to the Mediterranean Diet: A Cross-Sectional Study Open
Information on the consumption of ultra-processed foods (UPF) in relation to an adherence to the Mediterranean diet (MD) is limited. Our aim was to assess UPF consumption in a group of Italian adults and to evaluate the relationship with t…