Sofia Margiola
YOU?
Author Swipe
View article: A Tailored Phospho‐p53 Library Probes Antibody Specificity and Recognition Limitations
A Tailored Phospho‐p53 Library Probes Antibody Specificity and Recognition Limitations Open
The tumor suppressor protein p53, known as the “guardian of the genome,” is regulated by a complex network of post‐translational modifications. Phosphorylations at 7 Ser/Thr residues within the N‐terminal transactivation domain 1 (TAD1) pl…
View article: Semisynthetic ‘designer’ p53 sheds light on a phosphorylation–acetylation relay
Semisynthetic ‘designer’ p53 sheds light on a phosphorylation–acetylation relay Open
‘Designer’ p53: semi-synthesis of the tumor suppressor protein p53vianative chemical ligation enablesin vitrostructure–activity studies to reveal how this master regulator of cell fate is itself regulated by phosphorylation.