Bárbara Silva
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View article: How Duffy Blood Group ( <i>FY</i> ) Polymorphism and Age Modulate Vivax Malaria Risk at the Community Level: A Population-based Retrospective Cohort Study in the Amazon
How Duffy Blood Group ( <i>FY</i> ) Polymorphism and Age Modulate Vivax Malaria Risk at the Community Level: A Population-based Retrospective Cohort Study in the Amazon Open
Background A promoter variant commonly found in sub-Saharan Africans and their descendants disrupts Duffy antigen (Fy) expression on erythrocytes, leading to the Fy-negative phenotype, and confers partial resistance to blood-stage Plasmodi…
View article: Analysis of lymphoma subtypes, involved sites, and treatment outcomes in primary gastrointestinal B-cell lymphomas: A subset analysis within the PELÉ study of brazilian centers.
Analysis of lymphoma subtypes, involved sites, and treatment outcomes in primary gastrointestinal B-cell lymphomas: A subset analysis within the PELÉ study of brazilian centers. Open
Introduction: Primary gastrointestinal tract lymphomas (PGITL) are rare but are the most common site of extranodal presentation. The main subtypes include diffuse large B-cell lymphoma (DLBCL) and marginal zone lymphomas (MZL). PGITL are i…
View article: Unlocking New Frontiers: The Versatile Potential of the Brazilian Multipurpose Reactor
Unlocking New Frontiers: The Versatile Potential of the Brazilian Multipurpose Reactor Open
The multipurpose nature of nuclear research reactors has been investigated. This class of reactors has gained momentum within the international community, given the multiple benefits of nuclear technology in medicine, agriculture, industry…
View article: Differentially Private Anomaly Detection for Energy Market Data
Differentially Private Anomaly Detection for Energy Market Data Open
Differential privacy (DP) is often used to protect consumer privacy in controlled data disclosures. This paper applies DP technology in anomaly detection to safeguard the secrecy of business-sensitive data in Brazilian open energy markets,…
View article: Enhancing the Maturity and Diclofenac Metabolism Ability of Mesenchymal Stem Cell‐Derived Human Hepatocytes In Vitro Using Microfluidics Technology
Enhancing the Maturity and Diclofenac Metabolism Ability of Mesenchymal Stem Cell‐Derived Human Hepatocytes In Vitro Using Microfluidics Technology Open
Human stem cell‐derived hepatocyte‐like cells (HLCs) represent a powerful tool for testing the efficacy and safety of novel therapies. However, most traditional 2D in vitro models yield HLCs with unpaired hepatic functions, hampering HLCs’…
View article: Analysis of the demographic profile and influences on the prognosis of COVID-19 treated at a public hospital
Analysis of the demographic profile and influences on the prognosis of COVID-19 treated at a public hospital Open
Objectives: The objectives of this retrospective cross-sectional study were to evaluate the demographic profile and aggravating factors in the prognosis of patients with COVID-19 in the years 2020 and 2022. Methods: From the analysis of me…
View article: ESTRATÉGIAS PARA PREVENÇÃO DA SENSIBILIDADE DENTAL PÓS CLAREAMENTO DENTAL: Revisão narrativa de literatura
ESTRATÉGIAS PARA PREVENÇÃO DA SENSIBILIDADE DENTAL PÓS CLAREAMENTO DENTAL: Revisão narrativa de literatura Open
Teeth whitening is the most sought-after method by patients to correct the color of their teeth. As it is a well-known and affordable procedure, the search for white teeth has been growing increasingly, mainly due to the influence of the m…
View article: Green Synthesis of Metallic Nanoparticles from Quercus Bark Extracts: Characterization and Functional Properties
Green Synthesis of Metallic Nanoparticles from Quercus Bark Extracts: Characterization and Functional Properties Open
Quercus species are utilized for their durable wood, providing sustenance for wildlife, conserving biodiversity, and contributing ecological, medicinal, and esthetic benefits to ecosystems and landscapes. In this study, we aimed to use the…
View article: Simple and Fast Preparation of Transparent Conductive Films of Silver Nanowires Obtained by a Salt Assisted Polyol Method
Simple and Fast Preparation of Transparent Conductive Films of Silver Nanowires Obtained by a Salt Assisted Polyol Method Open
Silver nanowires thin films have gained attention due to their excellent optical and electrical properties, being a potential material to be applied in optoelectronic devices as transparent conductive films, deposited on a substrate in a s…
View article: Halochromic Silk Fabric as a Reversible pH-Sensor Based on a Novel 2-Aminoimidazole Azo Dye
Halochromic Silk Fabric as a Reversible pH-Sensor Based on a Novel 2-Aminoimidazole Azo Dye Open
Textiles are important components for the development of lightweight and flexible displays useful in smart materials. In particular, halochromic textiles are fibrous materials with a color-changing ability triggered by pH variations mainly…
View article: Synergistic Antimicrobial Activity of Silver Nanoparticles with an Emergent Class of Azoimidazoles
Synergistic Antimicrobial Activity of Silver Nanoparticles with an Emergent Class of Azoimidazoles Open
The combination of two or more agents capable of acting in synergy has been reported as a valuable tool to fight against pathogens. Silver nanoparticles (AgNPs) present a strong antimicrobial action, although their cytotoxicity for healthy…
View article: Semi-Preparative Separation, Absolute Configuration, Stereochemical Stability and Effects on Human Neuronal Cells of MDPV Enantiomers
Semi-Preparative Separation, Absolute Configuration, Stereochemical Stability and Effects on Human Neuronal Cells of MDPV Enantiomers Open
Synthetic cathinones, such as 3,4-methylenedioxypyrovalerone (MDPV), are widely abused due to their psychostimulant effects. As they are chiral molecules, studies of their stereochemical stability (racemization can occur in certain tempera…
View article: Assessment of the Permeability of 3,4-Methylenedioxypyrovalerone (MDPV) across the Caco-2 Monolayer for Estimation of Intestinal Absorption and Enantioselectivity
Assessment of the Permeability of 3,4-Methylenedioxypyrovalerone (MDPV) across the Caco-2 Monolayer for Estimation of Intestinal Absorption and Enantioselectivity Open
3,4-Methylenedioxypyrovalerone (MDPV) is a widely studied synthetic cathinone heterocycle mainly concerning its psychoactive effects. It is a chiral molecule and one of the most abused new psychoactive substances worldwide. Enantioselectiv…
View article: Metabolism of Cathinones in Functional Hepatocyte-like Cells Derived from Human Neonatal Mesenchymal Stem Cells: An Enantioselectivity Approach
Metabolism of Cathinones in Functional Hepatocyte-like Cells Derived from Human Neonatal Mesenchymal Stem Cells: An Enantioselectivity Approach Open
Liver damage is a common issue associated with synthetic cathinones abuse. Indeed, human stem cell-derived hepatocyte-like cells (HLCs) have been used as alternative in vitro models for hepatotoxicity studies, due to their ability to maint…
View article: Fiscalin Derivatives as Potential Neuroprotective Agents
Fiscalin Derivatives as Potential Neuroprotective Agents Open
Neurodegenerative diseases (ND) share common molecular/cellular mechanisms that contribute to their progression and pathogenesis. In this sense, we are here proposing new neuroprotection strategies by using marine-derived compounds as fisc…
View article: Anxiety symptoms in critically ill COVID-19 survivors and its association with post-discharge health concerns
Anxiety symptoms in critically ill COVID-19 survivors and its association with post-discharge health concerns Open
Introduction Evidence suggest that critically ill COVID-19 patients are at higher risk of developing anxiety symptoms, which may be related to or exacerbated by patients concerns regarding their health status and recovery. Objectives To as…
View article: Synthetic Cathinones: Recent Developments, Enantioselectivity Studies and Enantioseparation Methods
Synthetic Cathinones: Recent Developments, Enantioselectivity Studies and Enantioseparation Methods Open
New psychoactive substances represent a public health threat since they are not controlled by international conventions, are easily accessible online and are sold as a legal alternative to illicit drugs. Among them, synthetic cathinones ar…
View article: Enantioselectivity of Pentedrone and Methylone on Metabolic Profiling in 2D and 3D Human Hepatocyte-like Cells
Enantioselectivity of Pentedrone and Methylone on Metabolic Profiling in 2D and 3D Human Hepatocyte-like Cells Open
Pentedrone and methylone can express stereoselectivity in toxicokinetic and toxicodynamic processes. Similarly, their chiral discrimination in metabolism, which was not yet evaluated, can result in different metabolic profiles and subseque…
View article: Khat, a Cultural Chewing Drug: A Toxicokinetic and Toxicodynamic Summary
Khat, a Cultural Chewing Drug: A Toxicokinetic and Toxicodynamic Summary Open
Khat (Catha edulis) is a recreational, chewed herbal drug that has been used as a psychostimulant for centuries in East Africa and the Arabian Peninsula, namely in Somalia, Ethiopia, and Yemen. However, the growing worldwide availability o…
View article: Chiral Resolution and Enantioselectivity of Synthetic Cathinones: A Brief Review
Chiral Resolution and Enantioselectivity of Synthetic Cathinones: A Brief Review Open
Chiral discrimination has become one of the most important fields in analytical and medicinal chemistry, and forensic toxicology. The enantiomers may have different binding to proteins that may lead to many pharmacological and toxicologica…
View article: Chiral enantioresolution of cathinone derivatives present in “legal highs”, and enantioselectivity evaluation on cytotoxicity of 3,4-methylenedioxypyrovalerone (MDPV)
Chiral enantioresolution of cathinone derivatives present in “legal highs”, and enantioselectivity evaluation on cytotoxicity of 3,4-methylenedioxypyrovalerone (MDPV) Open
Recently, great interest has been focused on synthetic cathinones since their consumption has increased exponentially. All synthetic cathinones exist as chiral molecules; the biological and/or toxicological properties of cathinones general…