Sofía Ocaña-Mayorga
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View article: Gut bacterial communities in roadkill animals: A pioneering study of two species in the Amazon region in Ecuador
Gut bacterial communities in roadkill animals: A pioneering study of two species in the Amazon region in Ecuador Open
Studying the microbial communities within the gastrointestinal tract of vertebrate species can provide insights into biodiversity, disease ecology, and conservation. Currently, we have very limited understanding of the composition of endog…
View article: Phenotypic resistance not associated with knockdown mutations (kdr) in Anopheles albimanus exposed to deltamethrin in southern coastal Ecuador
Phenotypic resistance not associated with knockdown mutations (kdr) in Anopheles albimanus exposed to deltamethrin in southern coastal Ecuador Open
View article: Additional file 1 of Phenotypic resistance not associated with knockdown mutations (kdr) in Anopheles albimanus exposed to deltamethrin in southern coastal Ecuador
Additional file 1 of Phenotypic resistance not associated with knockdown mutations (kdr) in Anopheles albimanus exposed to deltamethrin in southern coastal Ecuador Open
Additional file 1: Table S1. Counting of individuals alive and knockdown of five CDC bioassays carried out in An. albimanus from Huaquillas and Santa Rosa (southern coastal Ecuador) of 2–5 days old exposed to a deltamethrin dose of 12,5 mg…
View article: From roads to biobanks: Roadkill animals as a valuable source of genetic data
From roads to biobanks: Roadkill animals as a valuable source of genetic data Open
To protect biodiversity we must understand its structure and composition including the bacteria and microparasites associated with wildlife, which may pose risks to human health. However, acquiring this knowledge often presents challenges,…
View article: Evaluation of the Effectiveness of Chemical Control for Chagas Disease Vectors in Loja Province, Ecuador
Evaluation of the Effectiveness of Chemical Control for Chagas Disease Vectors in Loja Province, Ecuador Open
The objective of this study was to evaluate the effectiveness of selective and community-wide house insecticide spraying in controlling triatomines in the subtropical areas of Loja Province, Ecuador. We designed a quasi-experimental pre-po…
View article: Evaluation of Selective Deltamethrin Application with Household and Community Awareness for the Control of Chagas Disease in Southern Ecuador
Evaluation of Selective Deltamethrin Application with Household and Community Awareness for the Control of Chagas Disease in Southern Ecuador Open
Chagas disease is endemic in ~70% of Ecuador. Rhodnius ecuadoriensis and Triatoma carrioni (Hemiptera: Reduviidae) are the primary vectors of Chagas disease in Southern Ecuador. This study tested the effectiveness of selective deltamethrin…
View article: Population genomics and geographic dispersal in Chagas disease vectors: Landscape drivers and evidence of possible adaptation to the domestic setting
Population genomics and geographic dispersal in Chagas disease vectors: Landscape drivers and evidence of possible adaptation to the domestic setting Open
Accurate prediction of vectors dispersal, as well as identification of adaptations that allow blood-feeding vectors to thrive in built environments, are a basis for effective disease control. Here we adopted a landscape genomics approach t…
View article: Seroprevalence of Trypanosoma cruzi in Rural Ecuador and Clustering of Seropositivity within Households
Seroprevalence of Trypanosoma cruzi in Rural Ecuador and Clustering of Seropositivity within Households Open
We performed a cross-sectional study of Trypanosoma cruzi seroprevalence in 14 communities in three provinces of Ecuador and estimated the magnitude of the association of seropositive individuals within households. A total of 3,286 subject…
View article: Human Blood Meals in Sylvatic Triatomines Challenges Domestic-Centered Strategies for Prevention of Trypanosoma cruzi Transmission in Ecuador
Human Blood Meals in Sylvatic Triatomines Challenges Domestic-Centered Strategies for Prevention of Trypanosoma cruzi Transmission in Ecuador Open
Transmission risk of Chagas disease has been associated with human-vector contacts and triatomines colonizing dwellings, but alternative scenarios, independent of domestic colonization, are poorly documented. In the present work, we estima…
View article: The genomic basis of domestic colonisation and dispersal in Chagas disease vectors
The genomic basis of domestic colonisation and dispersal in Chagas disease vectors Open
The biology of vector adaptation to the human habitat remains poorly understood for many arthropod-borne diseases but underpins effective and sustainable disease control. We adopted a landscape genomics approach to investigate gene flow, s…
View article: Repeat-Driven Generation of Antigenic Diversity in a Major Human Pathogen, Trypanosoma cruzi
Repeat-Driven Generation of Antigenic Diversity in a Major Human Pathogen, Trypanosoma cruzi Open
Trypanosoma cruzi , a zoonotic kinetoplastid protozoan parasite, is the causative agent of American trypanosomiasis (Chagas disease). Having a very plastic, repetitive and complex genome, the parasite displays a highly diverse repertoire o…
View article: Triatomine Feeding Profiles and Trypanosoma cruzi Infection, Implications in Domestic and Sylvatic Transmission Cycles in Ecuador
Triatomine Feeding Profiles and Trypanosoma cruzi Infection, Implications in Domestic and Sylvatic Transmission Cycles in Ecuador Open
Understanding the blood meal patterns of insects that are vectors of diseases is fundamental in unveiling transmission dynamics and developing strategies to impede or decrease human–vector contact. Chagas disease has a complex transmission…
View article: Culture-free genome-wide locus sequence typing (GLST) provides new perspectives on Trypanosoma cruzi dispersal and infection complexity
Culture-free genome-wide locus sequence typing (GLST) provides new perspectives on Trypanosoma cruzi dispersal and infection complexity Open
Analysis of genetic polymorphism is a powerful tool for epidemiological surveillance and research. Powerful inference from pathogen genetic variation, however, is often restrained by limited access to representative target DNA, especially …
View article: Anopheline and human drivers of malaria risk in northern coastal, Ecuador: a pilot study
Anopheline and human drivers of malaria risk in northern coastal, Ecuador: a pilot study Open
View article: Genome-wide locus sequence typing (GLST) of eukaryotic pathogens
Genome-wide locus sequence typing (GLST) of eukaryotic pathogens Open
Analysis of genetic polymorphism is a powerful tool for epidemiological surveillance and research. Powerful inference from pathogen genetic variation, however, is often restrained by limited access to representative target DNA, especially …
View article: Influence of ecological factors on the presence of a triatomine species associated with the arboreal habitat of a host of Trypanosoma cruzi
Influence of ecological factors on the presence of a triatomine species associated with the arboreal habitat of a host of Trypanosoma cruzi Open
We observed that tree height influences nest site selection, which is consistent with previous observations of squirrel species. Factors such as the diameter at breast height and the interaction between tree height and tree species were no…
View article: Repeat-driven generation of antigenic diversity in a major human pathogen <i>Trypanosoma cruzi</i>
Repeat-driven generation of antigenic diversity in a major human pathogen <i>Trypanosoma cruzi</i> Open
Trypanosoma cruzi , a zoonotic kinetoplastid protozoan with a complex genome, is the causative agent of American trypanosomiasis (Chagas disease). The parasite uses a highly diverse repertoire of surface molecules, with roles in cell invas…
View article: Distribution of triatomine species in domestic and peridomestic environments in central coastal Ecuador
Distribution of triatomine species in domestic and peridomestic environments in central coastal Ecuador Open
According the results, approximately 571,000 people would be at high risk for T. cruzi infection in Manabí province. A multidisciplinary approximation and the adhesion to a periodic integrated vector management (IVM) program are essential …
View article: 2b-RAD genotyping for population genomic studies of Chagas disease vectors: Rhodnius ecuadoriensis in Ecuador
2b-RAD genotyping for population genomic studies of Chagas disease vectors: Rhodnius ecuadoriensis in Ecuador Open
Our findings suggest that 2b-RAD genotyping is both a cost effective and methodologically simple approach for generating high resolution genomic data for Chagas disease vectors with the power to distinguish between different vector populat…
View article: Prediction and Prevention of Parasitic Diseases Using a Landscape Genomics Framework
Prediction and Prevention of Parasitic Diseases Using a Landscape Genomics Framework Open
View article: Prevalence, Genetic Characterization, and 18S Small Subunit Ribosomal RNA Diversity of <i>Trypanosoma rangeli</i>in Triatomine and Mammal Hosts in Endemic Areas for Chagas Disease in Ecuador
Prevalence, Genetic Characterization, and 18S Small Subunit Ribosomal RNA Diversity of <i>Trypanosoma rangeli</i>in Triatomine and Mammal Hosts in Endemic Areas for Chagas Disease in Ecuador Open
Trypanosoma rangeli is a nonpathogenic parasite for humans; however, its medical importance relies in its similarity and overlapping distribution with Trypanosoma cruzi, causal agent of Chagas disease in the Americas. The genetic diversity…
View article: Bats, Trypanosomes, and Triatomines in Ecuador: New Insights into the Diversity, Transmission, and Origins of Trypanosoma cruzi and Chagas Disease
Bats, Trypanosomes, and Triatomines in Ecuador: New Insights into the Diversity, Transmission, and Origins of Trypanosoma cruzi and Chagas Disease Open
The generalist parasite Trypanosoma cruzi has two phylogenetic lineages associated almost exclusively with bats-Trypanosoma cruzi Tcbat and the subspecies T. c. marinkellei. We present new information on the genetic variation, geographic d…
View article: Comprehensive Survey of Domiciliary Triatomine Species Capable of Transmitting Chagas Disease in Southern Ecuador
Comprehensive Survey of Domiciliary Triatomine Species Capable of Transmitting Chagas Disease in Southern Ecuador Open
To date, only limited vector control efforts have been implemented. Together with recent reports of widespread sylvatic triatomine infestation and frequent post-intervention reinfestation, these results show that an estimated 100,000 peopl…
View article: Trypanosoma cruzi population dynamics in the Central Ecuadorian Coast
Trypanosoma cruzi population dynamics in the Central Ecuadorian Coast Open
Chagas disease is the most important parasitic disease in Latin America. The causative agent, Trypanosoma cruzi, displays high genetic diversity and circulates in complex transmission cycles among domestic, peridomestic and sylvatic enviro…