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View article: Culture Systems and Quality Parameters for Clinical-grade Mesenchymal stromal cells
Culture Systems and Quality Parameters for Clinical-grade Mesenchymal stromal cells Open
Mesenchymal stromal cells (MSC) are a potential tool for cell-based therapies subject to intensive investigation. MSCs display immunomodulatory functions and a broad differentiation capacity, and thus have several potential therapeutic app…
View article: The Utilization of Freezing Steps in Mesenchymal Stromal Cell (MSC) Manufacturing: Potential Impact on Quality and Cell Functionality Attributes
The Utilization of Freezing Steps in Mesenchymal Stromal Cell (MSC) Manufacturing: Potential Impact on Quality and Cell Functionality Attributes Open
Some recent reports suggest that cryopreserved and thawed mesenchymal stromal cells (MSCs) may have impaired functional properties as compared to freshly harvested MSCs from continuous cultures. A cryopreservation step in the manufacturing…
View article: Osteogenic differentiation of mesenchymal stromal cells in two-dimensional and three-dimensional cultures without animal serum
Osteogenic differentiation of mesenchymal stromal cells in two-dimensional and three-dimensional cultures without animal serum Open
Introduction Bone marrow-derived mesenchymal stromal cells (MSCs) have been intensely studied for the purpose of developing solutions for clinical tissue engineering. Autologous MSCs can potentially be used to replace tissue defects, but t…
View article: A robust and reproducible animal serum-free culture method for clinical-grade bone marrow-derived mesenchymal stromal cells
A robust and reproducible animal serum-free culture method for clinical-grade bone marrow-derived mesenchymal stromal cells Open
Efficient xenofree expansion methods to replace fetal bovine serum (FBS)-based culture methods are strongly encouraged by the regulators and are needed to facilitate the adoption of mesenchymal stromal cell (MSC)-based therapies. In the cu…