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Conjoined Deep Inferior Epigastric Artery Perforator and Superficial Inferior Epigastric Artery Free Flap Reconstruction After Excision of a Giant Phyllodes Tumor Open
Summary: Phyllodes tumors are rare fibroepithelial breast neoplasms that occasionally present as giant masses, requiring radical excision and complex reconstruction. We report the case of a 21-year-old woman who presented with a progressiv…
Repurposing bacterial lysates: Engineering inhalable locust bean gum microparticles for respiratory infection prevention Open
This study explores the development of inhalable microparticles containing bacterial lysates (BL) from multiple relevant bacterial species that include Staphylococcus aureus, Streptococcus pyogenes and Klebsiella pneumoniae, and locust bea…
Additive manufacturing of microneedles: a quality by design approach to clinical translation Open
Transdermal drug delivery systems (TDDS) offer a painless and non-invasive route of administration but are limited by the skin barrier. Microneedles (MNs) have been shown to overcome this challenge and enable the delivery of small molecule…
View article: Dual-targeted hyaluronic acid conjugates on lipid nanoparticles improve delivery and efficacy against glioblastoma: The linkage leads the fate
Dual-targeted hyaluronic acid conjugates on lipid nanoparticles improve delivery and efficacy against glioblastoma: The linkage leads the fate Open
Glioblastoma (GB) presents a significant therapeutic challenge due to the barriers posed by the blood-brain barrier (BBB) and blood-tumor barrier (BTB), limiting effective drug delivery. This study explores modifying ultra-small nanostruct…
Biopolymer-enhanced PVA hydrogels for DNA delivery: Structural and functional characterization Open
Hydrogels are versatile materials with significant potential in biomedical applications, particularly for controlled release systems. In this study, poly(vinyl alcohol) (PVA)-based hydrogels were developed by incorporating chitosan (CHI), …
AQbD Approach Applied to NIR in a Complex Topical Formulation: Bifonazole as Case Study Open
Background: A key challenge in modern pharmaceutical research is developing predictive models for drug formulation behavior. Since permeability is closely linked to molecular properties, considering a broad of characteristics is essential …
3D Bioprinting Models for Glioblastoma: From Scaffold Design to Therapeutic Application Open
Conventional in vitro models fail to accurately mimic the tumor in vivo characteristics, being appointed as one of the causes of clinical attrition rate. Recent advances in 3D culture techniques, replicating essential physical and biochemi…
Unraveling rosmarinic acid anticancer mechanisms in oral cancer malignant transformation Open
Oral squamous cell carcinoma (OSCC) is expected to rise ca. 40 % by 2040. Rosmarinic acid (RA) has been recognized for its anticancer properties, although its role in OSCC has been neglected. This work exploits the activity of RA in 2D and…
boron neutron capture therapy for glioblastoma: The delivery dilemma Open
This review delves into boron neutron capture therapy (BNCT), a targeted alpha-particle radiotherapy that holds promise in oncology and has the potential to address concerns of efficacy and safety associated to conventional cancer therapie…
Organ-on-a-chip: Quo vademus? Applications and regulatory status Open
Organ-on-a-chip systems, also referred to as microphysiological systems (MPS), represent an advance in bioengineering microsystems designed to mimic key aspects of human organ physiology and function. Drawing inspiration from the intricate…
A switch-on chemo-photothermal nanotherapy impairs glioblastoma Open
Judiciously combined modality approaches have proved highly effective for treating most forms of cancer, including glioblastoma. Created in BioRender. Mendes, M. (2025) https://BioRender.com/z98a881.
Ferroptosis driven by nanoparticles for tackling glioblastoma Open
Glioblastoma (GBM) is the most aggressive, malignant, and drug-resistant brain tumor. There are no effective treatment options for GBM, which usually leads to relapses that cause patients to die a few months later. Ferroptosis, a newly dis…
Are we better together? Addressing a combined treatment of pitavastatin and temozolomide for brain cancer Open
Pitavastatin is commonly prescribed to treat hypercholesterolemia through the regulation of cholesterol biosynthesis. Interestingly, it has also demonstrated a great potential for treating brain tumors, although the detailed cytotoxic mech…
Old drugs, new tricks: Delivering pitavastatin-loaded nanostructured lipid carriers for glioblastoma treatment Open
Glioblastoma (GB) is the most common and lethal primary form of malignant brain cancers. Its intrinsic aggressiveness and the blood-brain barrier (BBB) are two major factors that limit the efficacy of standard therapies. In recent years, n…
The potential of exosomes as a new therapeutic strategy for glioblastoma Open
Glioblastoma (GBM) stands for the most common and aggressive type of brain tumour in adults. It is highly invasive, which explains its short rate of survival. Little is known about its risk factors, and current therapy is still ineffective…
View article: Trilayered nanocellulose-based patches loaded with acyclovir and hyaluronic acid for the treatment of herpetic lesions
Trilayered nanocellulose-based patches loaded with acyclovir and hyaluronic acid for the treatment of herpetic lesions Open
This study focuses on the preparation of layered bacterial nanocellulose (BNC) patches for drug delivery and wound healing in the context of herpes labialis. Nanostructured patches were prepared by selective aqueous diffusion of acyclovir …
Therapeutic-driven framework for bioequivalence assessment of complex topical generic drug products Open
Despite the continuous research on understanding how topical drugs and the skin interact, the development of a topical generic product remains a challenge. Due to their local action effect rather than systemic, establishing suitable framew…
Peptide-Hitchhiking for the Development of Nanosystems in Glioblastoma Open
Glioblastoma (GBM) remains the epitome of aggressiveness and lethality in the spectrum of brain tumors, primarily due to the blood-brain barrier (BBB) that hinders effective treatment delivery, tumor heterogeneity, and the presence of trea…
Organ-on-a-Chip: Ubi sumus? Fundamentals and Design Aspects Open
This review outlines the evolutionary journey from traditional two-dimensional (2D) cell culture to the revolutionary field of organ-on-a-chip technology. Organ-on-a-chip technology integrates microfluidic systems to mimic the complex phys…
In vitro studies into establishing therapeutic bioequivalence of complex topical products: Weight of evidence Open
Over the past decade, topically applied drug products have experienced extraordinary price increases, due to the shortage of multisource generic drug products. This occurrence is mainly related to the underlying challenges evolved in topic…