Sofia Radrizzani
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View article: Bacterial gene 5′ ends have unusual mutation rates that can mislead tests of selection
Bacterial gene 5′ ends have unusual mutation rates that can mislead tests of selection Open
Despite early assumptions of neutrality, numerous mechanisms are now thought to cause selection on synonymous mutations, commonly supported by a low evolutionary rate at synonymous sites ( K s ). This has been best evidenced in the first ~…
View article: Why AGG is associated with high transgene output: passenger effects and their implications for transgene design
Why AGG is associated with high transgene output: passenger effects and their implications for transgene design Open
In bacteria, high A and low G content of the 5′ end of the coding sequence (CDS) promotes low RNA stability, facilitating ribosomal initiation and subsequently a high protein to transcript ratio. Additionally, 5′ NGG codons are suppressive…