Sofia Salta
YOU?
Author Swipe
DNA methylation markers for oral cancer detection in non- and minimally invasive samples: a systematic review Open
More than 50% of oral cancer (OC) patients are diagnosed with advanced-stage disease associated with poor prognosis and quality of life, supporting an urgent need to improve early OC detection. The identification of effective molecular mar…
View article: Anti-tumour activity of Panobinostat in oesophageal adenocarcinoma and squamous cell carcinoma cell lines
Anti-tumour activity of Panobinostat in oesophageal adenocarcinoma and squamous cell carcinoma cell lines Open
Panobinostat exposure effectively impaired malignant features of oesophageal cancer cells. Because HDAC3 was shown to be overexpressed in oesophageal tumour samples, this epigenetic drug may represent an alternative therapeutic option for …
Preliminary outcomes of the Cervical Cancer Screening Program of Northern Portugal: A snapshot Open
Our study confirmed the reliability and effectiveness of first line HrHPV genotyping in the Cervical Cancer Screening Program of Northern Portugal. Nonetheless, it also raised concerns about excessive referral to colposcopy, with the inher…
Biomarkers for Pre-Treatment Risk Stratification of Prostate Cancer Patients: A Systematic Review Open
Background: Prostate cancer (PCa) is one of the most frequently occurring malignancies. Although most cases are not life-threatening, approximately 20% endure an unfavorable outcome. PSA-based screening reduced mortality but at the cost of…
OncoUroMiR: Circulating miRNAs for Detection and Discrimination of the Main Urological Cancers Using a ddPCR-Based Approach Open
The three most common genitourinary malignancies (prostate/kidney/bladder cancers) constitute a substantial proportion of all cancer cases, mainly in the elderly population. Early detection is key to maximizing the patients’ survival, but …
View article: Unveiling the epigenomic mechanisms of acquired platinum‐resistance in high‐grade serous ovarian cancer
Unveiling the epigenomic mechanisms of acquired platinum‐resistance in high‐grade serous ovarian cancer Open
Resistance to platinum‐based chemotherapy is the major cause of death from high‐grade serous ovarian cancer (HGSOC). We hypothesise that detection of specific DNA methylation changes may predict platinum resistance in HGSOC. Using a public…
View article: <scp>DNA</scp> methylation biomarkers accurately detect esophageal cancer prior and post neoadjuvant chemoradiation
<span>DNA</span> methylation biomarkers accurately detect esophageal cancer prior and post neoadjuvant chemoradiation Open
Background Esophageal cancer (ECa) is associated with high mortality, mostly due to late diagnosis, precluding curativeintent surgery. Hence, neoadjuvant chemoradiation (ChRT) is recommended in most patients regardless of histological subt…
View article: EP004/#741 DNA methylation landscape as a potential player in acquired-drug resistance in ovarian cancer
EP004/#741 DNA methylation landscape as a potential player in acquired-drug resistance in ovarian cancer Open
Objectives Development of therapeutic resistance is a major cause of mortality in high-grade serous ovarian cancer (HGSOC), thus a better understanding of acquired resistance mechanisms is needed. This study aimed to investigate how epigen…
LiKidMiRs: A ddPCR-Based Panel of 4 Circulating miRNAs for Detection of Renal Cell Carcinoma Open
Background: Decreased renal cell cancer-related mortality is an important societal goal, embodied by efforts to develop effective biomarkers enabling early detection and increasing the likelihood of curative treatment. Herein, we sought to…
Clinical Significance of ARID1A and ANXA1 in HER-2 Positive Breast Cancer Open
Background: trastuzumab is considered the standard of care for human epidermal growth factor receptor-2 (HER-2+) breast cancer patients. Regardless of the benefits of its use, many early-stage patients eventually recur, and usually, the di…
View article: A DNA Methylation-based Test for Esophageal Cancer Detection
A DNA Methylation-based Test for Esophageal Cancer Detection Open
Background: Esophageal cancer (ECa) is the 7 th most incident cancer and the 6 th leading cause of cancer-related death. Most patients are diagnosed with locally advanced or metastatic disease, enduring poor survival. Biomarkers enabling e…
View article: A DNA Methylation-based Test for Esophageal Cancer Detection
A DNA Methylation-based Test for Esophageal Cancer Detection Open
Background: Esophageal cancer (ECa) is the 7 th most incident cancer and the 6 th leading cause of cancer-related death. Most patients are diagnosed with locally advanced or metastatic disease, enduring poor survival. Biomarkers enabling e…
View article: A DNA Methylation-based Test for Esophageal Cancer Detection
A DNA Methylation-based Test for Esophageal Cancer Detection Open
Background Esophageal cancer (ECa) is the 7th most incident cancer and the 6th leading cause of cancer-related death. Most patients are diagnosed with locally advanced or metastatic disease, enduring poor survival. Biomarkers enabling earl…
Overexpression of circulating MiR-30b-5p identifies advanced breast cancer Open
Background Breast cancer (BrC) remains the leading cause of cancer-related death in women, mainly due to recurrent and/or metastatic events, entailing the need for biomarkers predictive of progression to advanced disease. MicroRNAs hold pr…
Predictive and Prognostic Value of Selected MicroRNAs in Luminal Breast Cancer Open
Breast cancer (BrC) is the most frequent malignancy and the leading cause of cancer death among women worldwide. Approximately 70% of BrC are classified as luminal-like subtype, expressing the estrogen receptor. One of the most common and …
Predicting resistance to endocrine therapy in breast cancer: It's time for epigenetic biomarkers (Review) Open
Notwithstanding the marked progress in breast cancer (BC) management, it still constitutes the most common malignancy in women and a major cause of morbidity and mortality, thus remaining a major health issue worldwide. Most BC cases are h…
A DNA Methylation-Based Test for Breast Cancer Detection in Circulating Cell-Free DNA Open
Background: Breast cancer (BrC) is the most frequent neoplasm in women. New biomarkers, including aberrant DNA methylation, may improve BrC management. Herein, we evaluated the detection and prognostic performance of seven genes’ promoter …
Cell-Free DNA Methylation of Selected Genes Allows for Early Detection of the Major Cancers in Women Open
Background: Breast (BrC), colorectal (CRC) and lung (LC) cancers are the three most common and deadly cancers in women. Cancer screening entails an increase in early stage disease detection but is hampered by high false-positive rates and …
<span>FOXA</span>1 levels are decreased in pleural breast cancer metastases after adjuvant endocrine therapy, and this is associated with poor outcome Open
Estrogen receptor‐alpha ( ER α)‐positive breast cancer is often treated with antihormonal regimens. However, resistance to treatment is common, leading to metastatic disease. ER α activity requires the functional involvement of pioneer fac…
A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97 Open
Our findings demonstrate the advantages of using a combinatory approach to identify microRNAs downregulated due to aberrant promoter methylation. MiR-152-3p downregulation and promoter methylation was found to be prevalent in primary PCa, …
A posttranslational modification in histones as prognostic/predictive marker in Estrogen-Positive Breast Cancer Open
Aim: This work aims to evaluate H3K27me3 expression in luminal-like breast tumors, using immunohistochemistry assay, to assess the prognostic value of this epigenetic alterations in estrogen positive breast cancer (BrC). Introduction: BrC …