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View article: The Role of <scp>IgE</scp> in Crohn's Disease by Impairing the Capacity of Plasmacytoid Dendritic Cells to Generate <scp>FOXP3</scp><sup>+</sup> Tregs
The Role of <span>IgE</span> in Crohn's Disease by Impairing the Capacity of Plasmacytoid Dendritic Cells to Generate <span>FOXP3</span><sup>+</sup> Tregs Open
Background A causal relationship between Crohn's disease (CD) and asthma is reported, but the underlying mechanisms are not fully understood. We sought to investigate the role of IgE and IgE‐mediated pathways in the pathophysiology of CD. …
View article: Convergent evolution of monocyte differentiation in adult skin instructs Langerhans cell identity
Convergent evolution of monocyte differentiation in adult skin instructs Langerhans cell identity Open
Langerhans cells (LCs) maintain tissue and immunological homeostasis at the epidermal barrier site. They are unique among phagocytes in functioning both as embryo-derived, tissue-resident macrophages that influence skin innervation and rep…
View article: Impaired expression of metallothioneins contributes to Th17/TNF- mediated, allergen-induced inflammation in patients with atopic dermatitis.
Impaired expression of metallothioneins contributes to Th17/TNF- mediated, allergen-induced inflammation in patients with atopic dermatitis. Open
Supplementary Tables to manuscript Impaired expression of metallothioneins contributes to Th17/TNF- mediated, allergen - induced inflammation in patients with atopic dermatitis. Contain information on clinical characteristics, FLG status, …
View article: Skin programming of inflammatory responses to <i>Staphylococcus aureus</i> is compartmentalized according to epidermal keratinocyte differentiation status
Skin programming of inflammatory responses to <i>Staphylococcus aureus</i> is compartmentalized according to epidermal keratinocyte differentiation status Open
Background Acute cutaneous inflammation causes microbiome alterations as well as ultrastructural changes in epidermis stratification. However, the interactions between keratinocyte proliferation and differentiation status and the skin micr…
View article: Transcriptional programming of immunoregulatory responses in human Langerhans cells
Transcriptional programming of immunoregulatory responses in human Langerhans cells Open
Human epidermal Langerhans cells (LCs) maintain immune homeostasis in the skin. To examine transcriptional programming of human primary LCs during homeostasis, we performed scRNA-seq analysis of LCs before and after migration from the epid…
View article: TNFα SIGNALLING IN THE CUTANEOUS IMMUNE NETWORK INSTRUCTS LOCAL Th17 ALLERGEN-SPECIFIC INFLAMMATORY RESPONSES IN ATOPIC DERMATITIS
TNFα SIGNALLING IN THE CUTANEOUS IMMUNE NETWORK INSTRUCTS LOCAL Th17 ALLERGEN-SPECIFIC INFLAMMATORY RESPONSES IN ATOPIC DERMATITIS Open
Accurate regulation of cutaneous immunity is fundamental for human health and quality of life but is severely compromised in inflammatory skin disease. To investigate the molecular crosstalk underpinning tolerance vs inflammation in human …
View article: An IRF1-IRF4 Toggle-Switch Controls Tolerogenic and Immunogenic Transcriptional Programming in Human Langerhans Cells
An IRF1-IRF4 Toggle-Switch Controls Tolerogenic and Immunogenic Transcriptional Programming in Human Langerhans Cells Open
Langerhans cells (LCs) reside in the epidermis as a dense network of immune system sentinels, coordinating both immunogenic and tolerogenic immune responses. To determine molecular switches directing induction of LC immune activation, we p…
View article: TNF signalling fine-tunes Langerhans cell transcriptional programmes mediating adaptive immunity
TNF signalling fine-tunes Langerhans cell transcriptional programmes mediating adaptive immunity Open
Langerhans cells (LCs) reside in the epidermis as a dense network of immune system sentinels, coordinating both immunogenic and tolerogenic immune responses. To determine molecular switches directing induction of LC immune activation, we p…
View article: Machine learning applied to atopic dermatitis transcriptome reveals distinct therapy‐dependent modification of the keratinocyte immunophenotype*
Machine learning applied to atopic dermatitis transcriptome reveals distinct therapy‐dependent modification of the keratinocyte immunophenotype* Open
Our analysis of transcriptomic signatures in cutaneous disease biopsies reveals the effect of keratinocyte programming in skin inflammation and suggests that the perturbation of a single axis of immune signal alone may be insufficient to r…
View article: Langerhans cells immunocompetency is critical for IDO1-dependent ability to induce tolerogenic T cells
Langerhans cells immunocompetency is critical for IDO1-dependent ability to induce tolerogenic T cells Open
Human epidermal Langerhans cells (LCs) can coordinate both immunogenic and tolerogenic immune responses, creating an attractive opportunity for immunomodulation strategies. To investigate transcriptional determinants of human primary LC to…
View article: Machine learning applied to atopic dermatitis transcriptome reveals distinct therapy-dependent modification of the keratinocyte immunophenotype
Machine learning applied to atopic dermatitis transcriptome reveals distinct therapy-dependent modification of the keratinocyte immunophenotype Open
Background Atopic dermatitis (AD) arises from a complex interaction between an impaired epidermal barrier, environmental exposures, and the infiltration of Th1/Th2/Th17/Th22 T cells. Transcriptomic analysis has advanced understanding of ge…
View article: Data on genomic profiles, epigenomic profiles, phenotypic and functional characteristics of primary human Langerhans cells
Data on genomic profiles, epigenomic profiles, phenotypic and functional characteristics of primary human Langerhans cells Open
In this study, the authors analysed primary human Langerhans cells (LCs), using bulk and single-cell RNAseq as well as H3K4Me3 and H4K27Ac chromatin immunoprecipitation sequencing (ChIPseq), and coupled these genomic and epigenomic profile…
View article: Genomic programming of antigen cross-presentation in IRF4-expressing human Langerhans cells
Genomic programming of antigen cross-presentation in IRF4-expressing human Langerhans cells Open
Langerhans cells (LCs) in the epidermis present MHC I and MHC II-restricted antigens thereby priming either CD8 or CD4 T cell immune responses. The genomic programs and transcription factors regulating antigen presentation in LCs remain to…
View article: Langerhans Cells—Programmed by the Epidermis
Langerhans Cells—Programmed by the Epidermis Open
Langerhans cells (LCs) reside in the epidermis as a dense network of immune system sentinels. These cells determine the appropriate adaptive immune response (inflammation or tolerance) by interpreting the microenvironmental context in whic…
View article: Human dendritic cells activated with MV130 induce Th1, Th17 and IL‐10 responses via RIPK2 and MyD88 signalling pathways
Human dendritic cells activated with MV130 induce Th1, Th17 and IL‐10 responses via RIPK2 and MyD88 signalling pathways Open
Recurrent respiratory tract infections (RRTIs) are the first leading cause of community‐ and nosocomial‐acquired infections. Antibiotics remain the mainstay of treatment, enhancing the potential to develop antibiotic resistances. Therefore…
View article: Novel vaccines targeting dendritic cells by coupling allergoids to nonoxidized mannan enhance allergen uptake and induce functional regulatory T cells through programmed death ligand 1
Novel vaccines targeting dendritic cells by coupling allergoids to nonoxidized mannan enhance allergen uptake and induce functional regulatory T cells through programmed death ligand 1 Open
Allergoids conjugated to nonoxidized mannan represent suitable vaccines for AIT. Our findings might also be of the utmost relevance to development of therapeutic interventions in other immune tolerance-related diseases.