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View article: New Generation Stopped-Flow Time-Resolved BioSAXS Experiments at the P12 Beamline.
New Generation Stopped-Flow Time-Resolved BioSAXS Experiments at the P12 Beamline. Open
Time-resolved small-angle X-ray scattering enables studying dynamic structural changes in biological macromolecules. Developments in fast mixing devices, such as the significant reduction in sample volume requirements, now allow the techni…
View article: Enhancing high-energy powder X-ray diffraction applications using a PILATUS4 CdTe detector
Enhancing high-energy powder X-ray diffraction applications using a PILATUS4 CdTe detector Open
Hybrid photon counting detectors have significantly advanced synchrotron research. In particular, the introduction of large cadmium telluride-based detectors in 2015 enabled a whole new range of high-energy X-ray measurements. This article…
View article: Cryo‐ <scp>EM</scp> structure of the dopamine transporter with a novel atypical non‐competitive inhibitor bound to the orthosteric site
Cryo‐ <span>EM</span> structure of the dopamine transporter with a novel atypical non‐competitive inhibitor bound to the orthosteric site Open
The regulation of dopamine (DA) removal from the synaptic cleft is a crucial process in neurotransmission and is facilitated by the sodium‐ and chloride‐coupled dopamine transporter DAT. Psychostimulant drugs, cocaine, and amphetamine, bot…
View article: Inertial mixing of acoustically levitated droplets for time‐lapse protein crystallography
Inertial mixing of acoustically levitated droplets for time‐lapse protein crystallography Open
Varying the chemical consistency of acoustically levitated droplets opens up an in situ study of chemical and biochemical reactions in small volumes. However, the optimization of the mixing time and the minimization of the positional insta…
View article: Variations on a theme: crystal forms of the amino-acid transporter MhsT
Variations on a theme: crystal forms of the amino-acid transporter MhsT Open
The bacterial amino-acid transporter MhsT from the SLC6A family has been crystallized in complex with different substrates in order to understand the determinants of the substrate specificity of the transporter. Surprisingly, crystals of t…
View article: Variations of a theme - crystal forms of the amino acid transporter MhsT
Variations of a theme - crystal forms of the amino acid transporter MhsT Open
The bacterial amino acid transporter MhsT of the SLC6A family was crystallized in complex with different substrates in order to understand the determinants of substrate specificity of the transporter. Surprisingly, crystals of the differen…
View article: Insights into the mechanism of high lipid–detergent crystallization of membrane proteins
Insights into the mechanism of high lipid–detergent crystallization of membrane proteins Open
Obtaining well diffracting crystals of membrane proteins is often challenging, but chances can be improved by crystallizing them in lipidic conditions that mimic their natural membrane environments. One approach is the high lipid–detergent…
View article: Humidity-induced phase transitions of HEW lysozyme investigated by powder diffraction
Humidity-induced phase transitions of HEW lysozyme investigated by powder diffraction Open
The simplicity of XRPD data collection and the uniqueness of the diffraction pattern that each polymorph shows, marks powder diffraction as the most suitable technique for quick and accurate characterization of microcrystalline suspensions…
View article: Humidity induced phase transitions of HEW lysozyme investigated by microcrystalline powder diffraction
Humidity induced phase transitions of HEW lysozyme investigated by microcrystalline powder diffraction Open
Co-crystallisation is a common method for producing protein-ligand complex structures.It is especially useful when drug-like compounds trigger conformational changes in proteins.This can result in variations in the growing conditions or cr…