Sofia Winslow
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View article: Multi-omics links IL-6 trans-signalling with neutrophil extracellular trap formation and<i>Haemophilus</i>infection in COPD
Multi-omics links IL-6 trans-signalling with neutrophil extracellular trap formation and<i>Haemophilus</i>infection in COPD Open
Background: Interleukin (IL)-6 trans-signalling (IL-6TS) is emerging as a pathogenic mechanism in chronic respiratory diseases; however, the drivers of IL-6TS in the airways and the phenotypic characteristic of patients with increased IL-6…
View article: Datasets and metadata supporting the published article: Prognostic implications of the expression levels of different immunoglobulin heavy chain-encoding RNAs in early breast cancer
Datasets and metadata supporting the published article: Prognostic implications of the expression levels of different immunoglobulin heavy chain-encoding RNAs in early breast cancer Open
In this study, the authors used RNA-Seq data from two local population-based breast cancer cohorts to determine the expression of IGJ (a gene encoding the J chain protein component of the antibodies IgM and IgA) and immunoglobulin heavy (I…
View article: Macrophages attenuate the transcription of CYP1A1 in breast tumor cells and enhance their proliferation
Macrophages attenuate the transcription of CYP1A1 in breast tumor cells and enhance their proliferation Open
While aberrant cells are routinely recognized and removed by immune cells, tumors eventually escape innate immune responses. Infiltrating immune cells are even corrupted by the tumor to acquire a tumor-supporting phenotype. In line, tumor-…
View article: Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells
Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells Open
HuR plays an important role in tumor cell survival mainly through posttranscriptional upregulation of prominent anti-apoptotic genes. In addition, HuR can inhibit the translation of pro-apoptotic factors as we could previously report for c…
View article: Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment
Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment Open
While the importance of iron for tumor development is widely appreciated, the exact sources of tumor-supporting iron largely remain elusive. The possibility that iron might be provided by stromal cells in the tumor microenvironment was not…
View article: Additional file 4: of The expression pattern of matrix-producing tumor stroma is of prognostic importance in breast cancer
Additional file 4: of The expression pattern of matrix-producing tumor stroma is of prognostic importance in breast cancer Open
The R code used to generate signatures, figures and tables. (R 31Â kb)
View article: Additional file 5: of The expression pattern of matrix-producing tumor stroma is of prognostic importance in breast cancer
Additional file 5: of The expression pattern of matrix-producing tumor stroma is of prognostic importance in breast cancer Open
R object containing signatures defined in reference [17]. (RDATA 704 bytes)
View article: Additional file 6: of The expression pattern of matrix-producing tumor stroma is of prognostic importance in breast cancer
Additional file 6: of The expression pattern of matrix-producing tumor stroma is of prognostic importance in breast cancer Open
Information in Additional file 10 in Excel format. (XLSX 10Â kb)
View article: Down Regulation of CLDND1 Induces Apoptosis in Breast Cancer Cells
Down Regulation of CLDND1 Induces Apoptosis in Breast Cancer Cells Open
Identification of targets for apoptosis induction is important to provide novel therapeutic approaches in breast cancer. Our earlier studies showed that down regulation of protein kinase C δ (PKCδ) induces death in breast cancer cells. In …