Sofia Xanthoulea
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View article: P-422 Endometrial 17β-estradiol production by local steroid-metabolizing enzymes in IVF patients with recurrent implantation failure (RIF) versus control subjects
P-422 Endometrial 17β-estradiol production by local steroid-metabolizing enzymes in IVF patients with recurrent implantation failure (RIF) versus control subjects Open
Study question Is the endometrial synthesis and inactivation of 17β-estradiol by steroid-metabolizing enzymes altered between IVF patients with recurrent implantation failure (RIF) and control subjects? Summary answer Synthesis and inactiv…
View article: Endometrial metabolism of 17β-estradiol during the window of implantation in women with recurrent implantation failure
Endometrial metabolism of 17β-estradiol during the window of implantation in women with recurrent implantation failure Open
Objectives Alterations in 17β-estradiol metabolism are known to potentially impair endometrial receptivity. Previous pioneering studies have investigated the role of endometrial steroid metabolism by determining steroid hormone levels and …
View article: Murine Xenograft Models as Preclinical Tools in Endometrial Cancer Research
Murine Xenograft Models as Preclinical Tools in Endometrial Cancer Research Open
Murine xenograft models are valuable and increasingly used preclinical tools in cancer research to understand disease pathogenesis and guide treatment options. The aim of this narrative review is to summarize the studies that employed mous…
View article: Redefining the Position of Hormonal Therapy in Endometrial Cancer in the Era of Molecular Classification
Redefining the Position of Hormonal Therapy in Endometrial Cancer in the Era of Molecular Classification Open
Contains fulltext : 301042.pdf (Publisher’s version ) (Open Access)
View article: Human monocytes differentiate into tumor-associated macrophages upon SKOV3 cells coculture and/or lysophosphatidic acid stimulation
Human monocytes differentiate into tumor-associated macrophages upon SKOV3 cells coculture and/or lysophosphatidic acid stimulation Open
Background Serous ovarian carcinoma is the most common type of ovarian carcinoma. Tumor-associated macrophages (TAMs) promote ovarian cancer progression. Most macrophages are generated by monocyte differentiation. Lysophosphatidic acid (LP…
View article: An Applicable Machine Learning Model Based on Preoperative Examinations Predicts Histology, Stage, and Grade for Endometrial Cancer
An Applicable Machine Learning Model Based on Preoperative Examinations Predicts Histology, Stage, and Grade for Endometrial Cancer Open
Purpose To build a machine learning model to predict histology (type I and type II), stage, and grade preoperatively for endometrial carcinoma to quickly give a diagnosis and assist in improving the accuracy of the diagnosis, which can hel…
View article: Pharmacological inhibition of 17β-hydroxysteroid dehydrogenase impairs human endometrial cancer growth in an orthotopic xenograft mouse model
Pharmacological inhibition of 17β-hydroxysteroid dehydrogenase impairs human endometrial cancer growth in an orthotopic xenograft mouse model Open
Endometrial cancer (EC) is the most common gynaecological tumor in developed countries and its incidence is increasing. Approximately 80% of newly diagnosed EC cases are estrogen-dependent. Type 1 17β-hydroxysteroid dehydrogenase (17β-HSD-…
View article: Endometriotic cell culture contamination and authenticity: a source of bias in <i>in vitro</i> research?
Endometriotic cell culture contamination and authenticity: a source of bias in <i>in vitro</i> research? Open
STUDY QUESTION Are the primary cell cultures and cell lines used in endometriosis research of sufficient quality? SUMMARY ANSWER Primary cells used in endometriosis research lack purity and phenotypic characterisation, and cell lines are n…
View article: Intracrine Regulation of Estrogen and Other Sex Steroid Levels in Endometrium and Non-gynecological Tissues; Pathology, Physiology, and Drug Discovery
Intracrine Regulation of Estrogen and Other Sex Steroid Levels in Endometrium and Non-gynecological Tissues; Pathology, Physiology, and Drug Discovery Open
Our understanding of the intracrine (or local) regulation of estrogen and other steroid synthesis and degradation expanded in the last decades, also thanks to recent technological advances in chromatography mass-spectrometry. Estrogen resp…
View article: Development of an Image-Guided Orthotopic Xenograft Mouse Model of Endometrial Cancer with Controllable Estrogen Exposure
Development of an Image-Guided Orthotopic Xenograft Mouse Model of Endometrial Cancer with Controllable Estrogen Exposure Open
Endometrial cancer (EC) is the most common gynaecological malignancy in Western society and the majority of cases are estrogen dependent. While endocrine drugs proved to be of insufficient therapeutic value in the past, recent clinical res…
View article: Blocking 17β‐hydroxysteroid dehydrogenase type 1 in endometrial cancer: a potential novel endocrine therapeutic approach
Blocking 17β‐hydroxysteroid dehydrogenase type 1 in endometrial cancer: a potential novel endocrine therapeutic approach Open
The enzyme type 1 17β‐hydroxysteroid dehydrogenase (17β‐HSD‐1), responsible for generating active 17β‐estradiol (E2) from low‐active estrone (E1), is overexpressed in endometrial cancer (EC), thus implicating an increased intra‐tissue gene…
View article: Next-Generation Sequencing in Oncology: Genetic Diagnosis, Risk Prediction and Cancer Classification
Next-Generation Sequencing in Oncology: Genetic Diagnosis, Risk Prediction and Cancer Classification Open
Next-generation sequencing (NGS) technology has expanded in the last decades with significant improvements in the reliability, sequencing chemistry, pipeline analyses, data interpretation and costs. Such advances make the use of NGS feasib…