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View article: Dorsoventral limb patterning in paired appendages emerged via regulatory repurposing of an ancestral posterior fin module
Dorsoventral limb patterning in paired appendages emerged via regulatory repurposing of an ancestral posterior fin module Open
Limbs exhibit adaptive differentiation along their dorsal-ventral (DV) axis, determined by the dorsal expression of the LIM homeobox gene Lmx1b. The paired appendages (i.e. the pectoral and pelvic fins from which limbs evolved) arose in an…
View article: Establishment, conservation, and innovation of dorsal determination mechanisms during the evolution of vertebrate paired appendages
Establishment, conservation, and innovation of dorsal determination mechanisms during the evolution of vertebrate paired appendages Open
Limb function requires polarized anatomy across the dorsal-ventral (DV) axis, but it is unclear when the capacity for DV differentiation of paired appendages arose in evolution. Here we define ancestral DV patterning programs in the fins o…
View article: Dorsoventral limb patterning in paired appendages emerged via regulatory repurposing of an ancestral posterior fin module
Dorsoventral limb patterning in paired appendages emerged via regulatory repurposing of an ancestral posterior fin module Open
Limbs exhibit adaptive differentiation along their dorsoventral (DV) axis, determined by the dorsal expression of the LIM homeobox gene Lmx1b . The paired appendages (i.e. the pectoral and pelvic fins from which limbs evolved) arose in an …
View article: The limb dorsoventral axis: Lmx1b's role in development, pathology, evolution, and regeneration
The limb dorsoventral axis: Lmx1b's role in development, pathology, evolution, and regeneration Open
The limb anatomy displays well‐defined dorsal and ventral compartments, housing extensor, and flexor muscles, which play a crucial role in facilitating limb locomotion and manipulation. Despite its importance, the study of limb dorsoventra…
View article: Failure of digit tip regeneration in the absence of <i>Lmx1b</i> suggests Lmx1b functions disparate from dorsoventral polarity
Failure of digit tip regeneration in the absence of <i>Lmx1b</i> suggests Lmx1b functions disparate from dorsoventral polarity Open
Mammalian digit tip regeneration is linked to the presence of nail tissue, but a nail-explicit model is missing. Here, we report that nail-less double-ventral digits of Δ LARM1/2 mutants that lack limb-specific Lmx1b enhancers fail to rege…
View article: Time‐sequenced transcriptomes of developing distal mouse limb buds: A comparative tissue layer analysis
Time‐sequenced transcriptomes of developing distal mouse limb buds: A comparative tissue layer analysis Open
Background The development of the amniote limb has been an important model system to study patterning mechanisms and morphogenesis. For proper growth and patterning, it requires the interaction between the distal sub‐apical mesenchyme and …
View article: Elemental Composition in Female Dry Femora Using Portable X-Ray Fluorescence (pXRF): Association with Age and Osteoporosis
Elemental Composition in Female Dry Femora Using Portable X-Ray Fluorescence (pXRF): Association with Age and Osteoporosis Open
Pathophysiological conditions can modify the skeletal chemical concentration. This study analyzes the elemental composition in two anatomical regions from dry femoral bone using a portable X-Ray Fluorescence (pXRF) and evaluates its impact…
View article: Mammalian-specific ectodermal enhancers control the expression of <i>Hoxc</i> genes in developing nails and hair follicles
Mammalian-specific ectodermal enhancers control the expression of <i>Hoxc</i> genes in developing nails and hair follicles Open
Significance In this study, we report a unique and necessary function for the HoxC gene cluster in the development of some ectodermal organs, as illustrated both by the hair and nail phenotype displayed by mice lacking the Hoxc13 function …
View article: SPECIFIC ECTODERMAL ENHANCERS CONTROL THE EXPRESSION OF<i>Hoxc</i>GENES IN DEVELOPING MAMMALIAN INTEGUMENTS
SPECIFIC ECTODERMAL ENHANCERS CONTROL THE EXPRESSION OF<i>Hoxc</i>GENES IN DEVELOPING MAMMALIAN INTEGUMENTS Open
Vertebrate Hox genes are key players in the establishment of structures during the development of the main body axis. Subsequently, they play important roles either in organizing secondary axial structures such as the appendages, or during…