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View article: A fast and tiny current as common generator of slow regular pacemaking in brain and heart
A fast and tiny current as common generator of slow regular pacemaking in brain and heart Open
Slow pacemaking is a key physiological process in specific excitable cells, yet its underlying mechanisms remain debated. Here we identify a conserved, voltage-dependent pacemaker current that is essential for slow, regular firing in both …
View article: Co-agonist glycine controls the occurrence of bursts by activating extrasynaptic NMDARs in nigral dopamine neurons
Co-agonist glycine controls the occurrence of bursts by activating extrasynaptic NMDARs in nigral dopamine neurons Open
SUMMARY Dopamine control of movement initiation is correlated in time to the phasic activity of substantia nigra pars compacta neurons. The participation of NMDARs to the generation of bursts is essential but the mechanisms regulating thei…
View article: An unconventional conductance is required for pacemaking of nigral dopamine neurons
An unconventional conductance is required for pacemaking of nigral dopamine neurons Open
Although several ionic mechanisms are known to control rate and regularity of the pacemaker in dopamine (DA) neurons from the substantia nigra pars compacta (SNc), a conductance essential for pacing has yet to be defined. Here we provide p…