Sofiane Saada
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View article: Ultra-High-Frequency-Dielectrophoresis Microfluidic Biosensor to Detect the Transformation Potential of Extracellular Vesicles Derived from Cancer Stem Cells
Ultra-High-Frequency-Dielectrophoresis Microfluidic Biosensor to Detect the Transformation Potential of Extracellular Vesicles Derived from Cancer Stem Cells Open
Cancer stem cells (CSCs) remain challenging to isolate and characterize because of their plastic phenotype. To overcome this issue, we used a microfluidic lab-on-a-chip analysis approach based on ultra-high frequency dielectophoresis (UHF-…
View article: Lab-On-Chip UHF-Dielectrophoretic Cytometer for Colorectal Cancer Stem Cells Sorting
Lab-On-Chip UHF-Dielectrophoretic Cytometer for Colorectal Cancer Stem Cells Sorting Open
International audience
View article: UHF-Dielectrophoresis Microfluidic Lab-on-a-Chip to Detect the Transformation Potential of Extracellular Vesicles Derived From Cancer Stem Cells
UHF-Dielectrophoresis Microfluidic Lab-on-a-Chip to Detect the Transformation Potential of Extracellular Vesicles Derived From Cancer Stem Cells Open
Cancer stem cells remain a challenge to isolate and characterize because of their plastic phenotype. Using a microfluidic lab-on-a-chip based on ultra-high frequency dielectophoresis, we measured the electromagnetic signature of colorectal…
View article: Ultra High Frequency Dielectrophoresis Manipulation to Monitor the Kinetics of Glioblastoma Cells Stemness Phenotype Acquirement
Ultra High Frequency Dielectrophoresis Manipulation to Monitor the Kinetics of Glioblastoma Cells Stemness Phenotype Acquirement Open
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View article: Microfluidic Lab-on-a-Chip Based on UHF-Dielectrophoresis for Stemness Phenotype Characterization and Discrimination among Glioblastoma Cells
Microfluidic Lab-on-a-Chip Based on UHF-Dielectrophoresis for Stemness Phenotype Characterization and Discrimination among Glioblastoma Cells Open
Glioblastoma (GBM) is one of the most aggressive solid tumors, particularly due to the presence of cancer stem cells (CSCs). Nowadays, the characterization of this cell type with an efficient, fast and low-cost method remains an issue. Hen…
View article: Microfluidic Lab-On-a-Chip based on UHF-Dielectrophoresis for Stemness Phenotype Characterization and Discrimination among Glioblastoma Cells
Microfluidic Lab-On-a-Chip based on UHF-Dielectrophoresis for Stemness Phenotype Characterization and Discrimination among Glioblastoma Cells Open
Glioblastoma (GBM) is one of the most aggressive solid tumors, particularly due to the presence of cancer stem cells (CSCs). Today the characterization of this type of cells with an efficient, fast and low-cost method remains an issue. Hen…
View article: Radiotherapy induces specific miRNA expression profiles in glioblastoma exosomes
Radiotherapy induces specific miRNA expression profiles in glioblastoma exosomes Open
Background Glioblastoma (GBM) is the most aggressive and frequent primary brain tumor during adulthood. One of the major treatments is the association of surgery and a combination of chemo and radiotherapies. Despite its immediate efficien…
View article: Characterization of Glioblastoma Cancer Stem Cells Sorted by Sedimentation Field-Flow Fractionation Using an Ultrahigh-Frequency Range Dielectrophoresis Biosensor
Characterization of Glioblastoma Cancer Stem Cells Sorted by Sedimentation Field-Flow Fractionation Using an Ultrahigh-Frequency Range Dielectrophoresis Biosensor Open
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View article: Autophagy inhibition reinforces stemness together with exit from dormancy of polydisperse glioblastoma stem cells
Autophagy inhibition reinforces stemness together with exit from dormancy of polydisperse glioblastoma stem cells Open
Therapeutic resistance and infiltrative capacities justify the aggressiveness of glioblastoma. This is due to cellular heterogeneity, especially the presence of stemness-related cells, i.e. Cancer Stem Cells (CSC). Previous studies focused…
View article: A High Frequency Dielectrophoresis Cytometer for Continuous Flow Biological Cells Refinement
A High Frequency Dielectrophoresis Cytometer for Continuous Flow Biological Cells Refinement Open
This paper presents a microfluidic radiofrequency device operating at a few hundred MHz, which is able to sort biological cells. It uses a non-invasive and label-free technic based on intracellular dielectric specificities of biological ce…
View article: A High Frequency Dielectrophorosis Cytometer for Continuous Flow Biological Cells Refinement
A High Frequency Dielectrophorosis Cytometer for Continuous Flow Biological Cells Refinement Open
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View article: Overexpression of sortilin is associated with 5‐FU resistance and poor prognosis in colorectal cancer
Overexpression of sortilin is associated with 5‐FU resistance and poor prognosis in colorectal cancer Open
Colorectal cancer (CRC) is the third most common cancer worldwide. Even if 5‐fluorouracil (5‐FU) is used as the first‐line chemotherapeutic drug, responsiveness is only 20‐30%. Acquired resistance to 5‐FU contributes to both poor patient p…
View article: The effect of nsPEF on glioblastoma cancer-like stem cell transcription and protein expression
The effect of nsPEF on glioblastoma cancer-like stem cell transcription and protein expression Open
International audience
View article: Human Medulloblastoma Cell Lines: Investigating on Cancer Stem Cell-Like Phenotype
Human Medulloblastoma Cell Lines: Investigating on Cancer Stem Cell-Like Phenotype Open
Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Despite the progress of new treatments, the risk of recurrence, morbidity, and death remains significant and the long-term adverse effects in survivors are substantia…
View article: A New Label-Free Approach to Glioblastoma Cancer Stem Cell Sorting and Detection
A New Label-Free Approach to Glioblastoma Cancer Stem Cell Sorting and Detection Open
Cancer stem cells (CSCs) play critical roles in cancer, making them important targets for new diagnostic and therapeutic approaches. Since CSCs are heterogeneous and not abundant in tumors, and few specific markers for these cells currentl…
View article: Ultra-High Frequencies continuous biological cell sorting based on repulsive and low dielectrophoresis forces
Ultra-High Frequencies continuous biological cell sorting based on repulsive and low dielectrophoresis forces Open
<p>Conference Paper entitled "Ultra-High Frequencies continuous biological cell sorting based on repulsive and low dielectrophoresis forces " for the IEEE IMS symposium 11-15 June 2019, Boston, USA</p>
View article: SUMCASTEC_190203_NA_JERM paper_Journal paper_.pdf_Limoges_R. Manczak_Public_Last draft
SUMCASTEC_190203_NA_JERM paper_Journal paper_.pdf_Limoges_R. Manczak_Public_Last draft Open
Journal of "UHF-Dielectrophoresis Crossover Frequency as a New Marker for Discrimination of Glioblastoma Undifferentiated Cells" published in IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology, February 2019.
View article: Regulatory Roles of Sortilin and SorLA in Immune-Related Processes
Regulatory Roles of Sortilin and SorLA in Immune-Related Processes Open
Sortilin, also known as Neurotensin Receptor-3, and the sorting-related receptor with type-A repeats (SorLA) are both members of the Vps10p domain receptor family. Initially identified in CNS cells, they are expressed in various other cell…
View article: SUMCASTEC_181003_NA_EMF-Med 2018 Paper_Conference paper_.pdf_Bangor_C. Palego_Public_Last Draft
SUMCASTEC_181003_NA_EMF-Med 2018 Paper_Conference paper_.pdf_Bangor_C. Palego_Public_Last Draft Open
Conference paper entitled "Permittivity measurements of brain cancer cell towards the electric characterisation of single Cancer Stem Cells" accepted in the 1st EMF-Med World Conference on Biomedical Applications of Electromagnetic Fields.…
View article: SUMCASTEC_181003_NA_EMF-Med 2018 Pres_Conference presentation_.pdf_Limoges_A.Pothier_Public_NA
SUMCASTEC_181003_NA_EMF-Med 2018 Pres_Conference presentation_.pdf_Limoges_A.Pothier_Public_NA Open
Presentation of conference paper entitled "High-Frequency Dielectrophoresis Characterization of Differentiated vs Undifferentiated Medulloblastoma Cells" at the 1st EMF-Med World Conference on Biomedical Applications of Electromagnetic Fie…
View article: High-Frequency Dielectrophoresis Characterization of Differentiated vs Undifferentiated Medulloblastoma Cells
High-Frequency Dielectrophoresis Characterization of Differentiated vs Undifferentiated Medulloblastoma Cells Open
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View article: CD226 opposes TIGIT to disrupt Tregs in melanoma
CD226 opposes TIGIT to disrupt Tregs in melanoma Open
CD4+ Tregs impede T cell responses to tumors. They express multiple inhibitory receptors that support their suppressive functions, including T cell Ig and ITIM domain (TIGIT). In melanoma patients, we show that Tregs exhibit increased TIGI…
View article: SPOT-008 Neurotensin receptor type 2 protects B-cell chronic lymphocytic leukaemia cells from apoptosis
SPOT-008 Neurotensin receptor type 2 protects B-cell chronic lymphocytic leukaemia cells from apoptosis Open
Introduction B-cell chronic lymphocytic leukaemia (B-CLL) cells are resistant to apoptosis, and consequently accumulate to the detriment of normal B cells and patient immunity. Because current therapies fail to eradicate these apoptosis-r…
View article: p75 neurotrophin receptor and pro-BDNF promote cell survival and migration in clear cell renal cell carcinoma
p75 neurotrophin receptor and pro-BDNF promote cell survival and migration in clear cell renal cell carcinoma Open
p75NTR, a member of TNF receptor family, is the low affinity receptor common to several mature neurotrophins and the high affinity receptor for pro-neurotrophins. Brain-Derived Neurotrophic Factor (BDNF), a member of neurotrophin family ha…