Sofie Bliddal
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View article: Interpretation of the association between thyroid peroxidase antibodies and thyroid function during pregnancy: An individual participant data meta-analysis
Interpretation of the association between thyroid peroxidase antibodies and thyroid function during pregnancy: An individual participant data meta-analysis Open
During pregnancy, TPOAbs were dose-dependently associated with TSH, FT4, and the risk of abnormal thyroid function. With concentrations below currently used positivity cut-offs, TPOAbs could be associated with lower maternal thyroid functi…
View article: P-473 Adenomyosis progression over time in patients with repeated pregnancy loss: ultrasound-based observations
P-473 Adenomyosis progression over time in patients with repeated pregnancy loss: ultrasound-based observations Open
Study question Does adenomyosis progress over time in women with two or more pregnancy losses? Summary answer Among women with two or more pregnancy losses, adenomyosis tends to gradually progress over time with notable changes observed in…
View article: O-218 Symptoms and signs of adenomyosis according to the revised MUSA criteria in 375 women with pregnancy loss and known ploidy of the pregnancy loss
O-218 Symptoms and signs of adenomyosis according to the revised MUSA criteria in 375 women with pregnancy loss and known ploidy of the pregnancy loss Open
Study question • Does adenomyosis increase risk of euploid pregnancy loss (PL)? • Is there a correlation of euploid PL and direct and/or indirect features of adenomyosis? Summary answer No increased risk of euploid PL was observed in women…
View article: O-156 Pregnancy loss has significant mental health consequences, a prospective cohort study of 2,085 women and 1,212 partners
O-156 Pregnancy loss has significant mental health consequences, a prospective cohort study of 2,085 women and 1,212 partners Open
Study question What is the prevalence of stress, depression and anxiety among couples experiencing pregnancy loss and is this affected by reproductive history? Summary answer Depression, stress, and anxiety are common after pregnancy loss,…
View article: O-077 Novel findings of thyroid dysfunction in pregnancy loss – suggestions for screening and further research
O-077 Novel findings of thyroid dysfunction in pregnancy loss – suggestions for screening and further research Open
Study question Do women experiencing pregnancy loss have undetected high thyroid stimulating hormone (TSH) levels? Is thyroid (dys)function associated with the risk of a euploid pregnancy loss? Summary answer Few women with pregnancy loss …
View article: Sequence diversity lost in early pregnancy
Sequence diversity lost in early pregnancy Open
Every generation, the human genome is shuffled during meiosis and a single fertilized egg gives rise to all of the cells of the body1. Meiotic errors leading to chromosomal abnormalities are known causes of pregnancy loss2,…
View article: Susceptibility to and severity of SARS-CoV-2 infection according to prescription drug use–an observational study of 46,506 Danish healthcare workers
Susceptibility to and severity of SARS-CoV-2 infection according to prescription drug use–an observational study of 46,506 Danish healthcare workers Open
It is not well investigated whether exposure to specific drug classes is associated with COVID-19. We investigated the risk of SARS-CoV-2 infection and severe COVID-19 among healthcare workers according to prescription drug use. We conduct…
View article: Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants
Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants Open
The host genetics of SARS-CoV-2 has previously been studied based on cases from the earlier waves of the pandemic in 2020 and 2021, identifying 51 genomic loci associated with infection and/or severity. SARS-CoV-2 has shown rapid sequence …
View article: Defining Gestational Thyroid Dysfunction Through Modified Nonpregnancy Reference Intervals: An Individual Participant Meta-analysis
Defining Gestational Thyroid Dysfunction Through Modified Nonpregnancy Reference Intervals: An Individual Participant Meta-analysis Open
Background Establishing local trimester-specific reference intervals for gestational TSH and free T4 (FT4) is often not feasible, necessitating alternative strategies. We aimed to systematically quantify the diagnostic performance of stand…
View article: Evaluating risk factors in recurrent pregnancy loss: A prospective cohort study and its impact on live birth outcomes
Evaluating risk factors in recurrent pregnancy loss: A prospective cohort study and its impact on live birth outcomes Open
Recurrent pregnancy loss (RPL) affects 1-2 % of all couples trying to conceive and is a challenging heterogeneous condition. This study aimed to evaluate the prevalence and impact of various risk factors in patients suffering from RPL. We …
View article: Thyroid function monitoring during pregnancy in euthyroid women with thyroid autoimmunity
Thyroid function monitoring during pregnancy in euthyroid women with thyroid autoimmunity Open
Background Thyroid autoimmunity (TAI) may be present in 1–17% of pregnant women. Monitoring of thyroid function in euthyroid pregnant women positive for anti-thyroperoxidase antibodies (TPOAb+) is recommended. Objective To determine the pr…
View article: O-318 Decline of βhCG concentrations following pregnancy loss: exploring contributing factors
O-318 Decline of βhCG concentrations following pregnancy loss: exploring contributing factors Open
Study question Which factors impact βhCG decline after a pregnancy loss, thereby inhibiting return of menstrual cycle? Summary answer In pregnancy loss, decline in βhCG levels are influenced by gestational age, BMI, previous losses, and tr…
View article: Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis
Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis Open
Background: International guidelines recommend targeted screening to identify gestational thyroid dysfunction. However, currently used risk factors have questionable discriminative ability. We quantified the risk for thyroid …
View article: Clonal hematopoiesis and COVID‐19 hospitalization in Danish adults
Clonal hematopoiesis and COVID‐19 hospitalization in Danish adults Open
Clonal hematopoiesis of indeterminate potential (CHIP) refers to the nonmalignant clonal expansion of blood stem cells that carry somatic mutations in myeloid cancer-associated genes.1 The main driver of CHIP progression is age, but other …
View article: Prospective reproductive outcomes according to sperm parameters, including DNA fragmentation, in recurrent pregnancy loss
Prospective reproductive outcomes according to sperm parameters, including DNA fragmentation, in recurrent pregnancy loss Open
At referral, sperm DFI, morphology and concentration cannot be used to identify RPL couples at risk of another pregnancy loss. Increased baseline DFI was associated with difficulty achieving another pregnancy, and improving sperm morpholog…
View article: Risks of suboptimal and excessive thyroid hormone replacement across ages
Risks of suboptimal and excessive thyroid hormone replacement across ages Open
Background Hypothyroidism is prevalent at all ages and represents a non-communicable disease with preventable consequences. Method Narrative review. Review In children and adolescents, the most devastating consequences of undertreatment wi…
View article: Association of Gestational Free and Total Triiodothyronine With Gestational Hypertension, Preeclampsia, Preterm Birth, and Birth Weight: An Individual Participant Data Meta-analysis
Association of Gestational Free and Total Triiodothyronine With Gestational Hypertension, Preeclampsia, Preterm Birth, and Birth Weight: An Individual Participant Data Meta-analysis Open
Context Triiodothyronine (T3) is the bioactive form of thyroid hormone. In contrast to thyroid-stimulating hormone and free thyroxine, we lack knowledge on the association of gestational T3 with adverse obstetric outcomes. Objective To inv…
View article: TSH and FT4 Reference Interval Recommendations and Prevalence of Gestational Thyroid Dysfunction: Quantification of Current Diagnostic Approaches
TSH and FT4 Reference Interval Recommendations and Prevalence of Gestational Thyroid Dysfunction: Quantification of Current Diagnostic Approaches Open
Context Guidelines recommend use of population- and trimester-specific thyroid-stimulating hormone (TSH) and free thyroxine (FT4) reference intervals (RIs) in pregnancy. Since these are often unavailable, clinicians frequently rely on alte…
View article: Polyautoimmunity in patients with cutaneous lupus erythematosus: A nationwide sex- and age-matched cohort study from Denmark
Polyautoimmunity in patients with cutaneous lupus erythematosus: A nationwide sex- and age-matched cohort study from Denmark Open
Patients with CLE had higher prevalence and 5-year cumulative incidence of a non-LE autoimmune disease than the general population.
View article: Consequences of undertreatment of hypothyroidism
Consequences of undertreatment of hypothyroidism Open
View article: Contents
Contents Open
View article: O-262 The vaginal and faecal microbiome in women with recurrent pregnancy loss (RPL) before pregnancy according to the reproductive outcome after referral
O-262 The vaginal and faecal microbiome in women with recurrent pregnancy loss (RPL) before pregnancy according to the reproductive outcome after referral Open
Study question Is the vaginal or faecal microbiome different between primary RPL (pRPL) and secondary RPL (sRPL) patients, and is it related to reproductive outcome after referral? Summary answer Before pregnancy, the vaginal microbiome di…
View article: Anti-Müllerian hormone and live birth in unexplained recurrent pregnancy loss
Anti-Müllerian hormone and live birth in unexplained recurrent pregnancy loss Open
View article: TSH and FT4 Reference Intervals in Pregnancy: A Systematic Review and Individual Participant Data Meta-Analysis
TSH and FT4 Reference Intervals in Pregnancy: A Systematic Review and Individual Participant Data Meta-Analysis Open
Context Interpretation of thyroid function tests during pregnancy is limited by the generalizability of reference intervals between cohorts due to inconsistent methodology. Objective (1) To provide an overview of published reference interv…
View article: Association of Thyroid Peroxidase Antibodies and Thyroglobulin Antibodies with Thyroid Function in Pregnancy: An Individual Participant Data Meta-Analysis
Association of Thyroid Peroxidase Antibodies and Thyroglobulin Antibodies with Thyroid Function in Pregnancy: An Individual Participant Data Meta-Analysis Open
Objectives: Thyroid autoimmunity is common in pregnant women and associated with thyroid dysfunction and adverse obstetric outcomes. Most studies focus on thyroid peroxidase antibodies (TPOAbs) assessed by a negative-positive…
View article: Severe weight loss in a hypothyroid patient as an acute presentation of autoimmune polyglandular syndrome type II
Severe weight loss in a hypothyroid patient as an acute presentation of autoimmune polyglandular syndrome type II Open
Background Autoimmune disease, including autoimmune thyroid disease, with uncharacteristic symptoms can be due to additional severe disease. We report a life-threatening debut of autoimmune polyglandular syndrome type II (APS II) defined a…
View article: Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia:a systematic review and individual-participant data meta-analysis
Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia:a systematic review and individual-participant data meta-analysis Open
View article: The microbiome in reproductive health: protocol for a systems biology approach using a prospective, observational study design
The microbiome in reproductive health: protocol for a systems biology approach using a prospective, observational study design Open
STUDY QUESTION What is the microbiome profile across different body sites in relation to the normal menstrual cycle (with and without hormonal contraception), recurrent pregnancy loss (RPL) (before and during pregnancy, pregnancy loss or b…
View article: Acute and persistent symptoms in non-hospitalized PCR-confirmed COVID-19 patients
Acute and persistent symptoms in non-hospitalized PCR-confirmed COVID-19 patients Open
View article: Acute and persistent symptoms in non-hospitalized PCR-confirmed COVID-19 patients
Acute and persistent symptoms in non-hospitalized PCR-confirmed COVID-19 patients Open
Background Reports of persistent symptoms after hospitalization with COVID-19 have raised concern of a “long COVID” syndrome. This study aimed at characterizing acute and persistent symptoms in non- hospitalized patients with polymerase ch…