Sofie Martens
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View article: MLKL deficiency in BrafV600EPten−/− melanoma model results in a modest delay of nevi development and reduced lymph node dissemination in male mice
MLKL deficiency in BrafV600EPten−/− melanoma model results in a modest delay of nevi development and reduced lymph node dissemination in male mice Open
Cancers acquire several capabilities to survive the multistep process in carcinogenesis. Resisting cell death is one of them. Silencing of the necroptosis initiator Ripk3 occurs in a wide variety of cancer types including melanoma. Little …
View article: Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state
Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state Open
Significance Historically, programmed cell death by apoptosis is considered crucial for proper intestinal organogenesis and gut homeostasis. To challenge this concept, we generated caspase-3 and -7 double knockout mice specifically in inte…
View article: Tozasertib Analogues as Inhibitors of Necroptotic Cell Death
Tozasertib Analogues as Inhibitors of Necroptotic Cell Death Open
Receptor interacting protein kinase 1 (RIPK1) plays a crucial role in tumor necrosis factor (TNF)-induced necroptosis, suggesting that this pathway might be druggable. Most inhibitors of RIPK1 are classified as either type II or type III k…
View article: RIPK1-dependent cell death: a novel target of the Aurora kinase inhibitor Tozasertib (VX-680)
RIPK1-dependent cell death: a novel target of the Aurora kinase inhibitor Tozasertib (VX-680) Open
The Aurora kinase family (Aurora A, B and C) are crucial regulators of several mitotic events, including cytokinesis. Increased expression of these kinases is associated with tumorigenesis and several compounds targeting Aurora kinase are …
View article: Sorafenib inhibits therapeutic induction of necroptosis in acute leukemia cells
Sorafenib inhibits therapeutic induction of necroptosis in acute leukemia cells Open
Induction of necroptosis has emerged as an alternative approach to trigger programmed cell death, in particular in apoptosis-resistant cancer cells. Recent evidence suggests that kinase inhibitors targeting oncogenic B-RAF can also affect …