Sofie Midgley
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Primary care sentinel surveillance of influenza-like illness and laboratory detections of respiratory viral infections in Denmark, week 40 2021 to week 39 2023 Open
BACKGROUND The Danish respiratory virus sentinel surveillance system has monitored influenza-like illness and influenza virus activity for over 30 years. During the last decade, additional virus groups were added. In 2021, the system was u…
High throughput method for monitoring SARS-CoV-2 variants in wastewater by Nanopore sequencing Open
Early in the COVID-19 pandemic, it was hypothesized that wastewater-based surveillance could be used to monitor SARS-CoV-2 like it has been used to monitor poliovirus for decades. We present a high throughput laboratory procedure to quanti…
View article: Acute flaccid myelitis in Europe between 2016 and 2023: indicating the need for better registration
Acute flaccid myelitis in Europe between 2016 and 2023: indicating the need for better registration Open
Background Acute flaccid myelitis (AFM) is a rare polio-like condition affecting mainly children and characterised by severe, often persistent, weakness. It is one of several causes of acute flaccid paralysis (AFP), which manifests as acut…
View article: Epidemiological and Clinical Insights into Enterovirus Circulation in Europe, 2018–2023: A Multicenter Retrospective Surveillance Study
Epidemiological and Clinical Insights into Enterovirus Circulation in Europe, 2018–2023: A Multicenter Retrospective Surveillance Study Open
Background Enteroviruses (EV) cause yearly outbreaks with severe infections, particularly in young children. This study investigates EV circulation, age, and clinical presentations in Europe from 2018 to 2023. Methods Aggregated data were …
View article: Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021–2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study
Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021–2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study Open
Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of…
Results from the SARS-CoV-2 wastewater-based surveillance system in Denmark, July 2021 to June 2022 Open
The microbiological analysis of wastewater samples is increasingly used for the surveillance of SARS-CoV-2 globally. We described the setup process of the national SARS-CoV-2 wastewater-based surveillance system in Denmark, presented its m…
Detecting SARS-CoV-2 Omicron B.1.1.529 Variant in Wastewater Samples by Using Nanopore Sequencing Open
We report wastewater surveillance for SARS-CoV-2 variants of concern by using mutation-specific, real-time PCR and rapid nanopore sequencing. This surveillance might be useful for an early warning in a scenario in which a new variant is em…
Acute flaccid rhombencephalomyelitis with radiculitis in a child with an enterovirus A71 infection seen for the first time in Denmark: a case report Open
Background Acute flaccid myelitis is a serious condition of the spinal cord. More than 80% of patients experience a mild respiratory illness or fever consistent with a viral infection prior to acute flaccid myelitis development. Enteroviru…
View article: Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021
Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021 Open
We report a rapid increase in enterovirus D68 (EV-D68) infections, with 139 cases reported from eight European countries between 31 July and 14 October 2021. This upsurge is in line with the seasonality of EV-D68 and was presumably stimula…
European Non-Polio Enterovirus Network: Introduction of Hospital-Based Surveillance Network to Understand the True Disease Burden of Non-Polio Enterovirus and Parechovirus Infections in Europe Open
Background. Non-polio enteroviruses (EVs) and human parechoviruses (PeVs) cause a wide range of human infections. Limited data on their true disease burden exist as standardized European-wide surveillance is lacking. Aims. Our aim is to es…
View article: Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe
Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe Open
In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016-2018. Most E30 cases affected…
View article: Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe
Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe Open
In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016–2018. Most E30 cases affected…
Application of an Optimized Direct Lysis Method for Viral RNA Extraction Linking Contaminated Dates to Infection With Hepatitis A Virus Open
Consumption of dates has not been considered a common risk of hepatitis A virus (HAV) infection. In January 2018, an outbreak of hepatitis was identified with cases resident in all regions of Denmark. All the detected strains belonged to H…
Correction: Seasonality of ventricular fibrillation at first myocardial infarction and association with viral exposure Open
[This corrects the article DOI: 10.1371/journal.pone.0226936.].
Erratum: Seasonality of ventricular fibrillation at first myocardial infarction and association with viral exposure (PLoS ONE (2020)15:2(e0226936)Doi: 10.1371/journal.pone.0226936) Open
The fifteenth author's initials are indexed incorrectly in PubMed. The correct initials are: Fischer TK.
Seasonality of ventricular fibrillation at first myocardial infarction and association with viral exposure Open
[This corrects the article DOI: 10.1371/journal.pone.0226936.].
View article: Co-circulation of multiple enterovirus D68 subclades, including a novel B3 cluster, across Europe in a season of expected low prevalence, 2019/20
Co-circulation of multiple enterovirus D68 subclades, including a novel B3 cluster, across Europe in a season of expected low prevalence, 2019/20 Open
Enterovirus D68 (EV-D68) was detected in 93 patients from five European countries between 1 January 2019 and 15 January 2020, a season with expected low circulation. Patients were primarily children (n = 67, median age: 4 years), 59 patien…
View article: A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts
A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts Open
Polymerase chain reaction (PCR) detection has become the gold standard for diagnosis and typing of enterovirus (EV) and human parechovirus (HPeV) infections. Its effectiveness depends critically on using the appropriate sample types and hi…
Improving preparedness to respond to cross-border hepatitis A outbreaks in the European Union/European Economic Area: towards comparable sequencing of hepatitis A virus Open
Introduction Sequence-based typing of hepatitis A virus (HAV) is important for outbreak detection, investigation and surveillance. In 2013, sequencing was central to resolving a large European Union (EU)-wide outbreak related to frozen ber…
Improving preparedness to respond to cross-border hepatitis A outbreaks in the European Union/European Economic Area: towards comparable sequencing of hepatitis A virus Open
Introduction Sequence-based typing of hepatitis A virus (HAV) is important for outbreak detection, investigation and surveillance. In 2013, sequencing was central to resolving a large European Union (EU)-wide outbreak related to frozen ber…
Prevalence of anti-hepatitis E virus immunoglobulin G in HIV-infected individuals over three decades Open
HEV seroprevalence rates were stable in HIV-infected individuals from the early 1980s to 2013. Rates increased with age. No evidence of persistent HEV infection was detected. Infection with HEV is frequent, but persistent HEV infection is …
Hepatitis A outbreak disproportionately affecting men who have sex with men (MSM) in the European Union and European Economic Area, June 2016 to May 2017 Open
Between 1 June 2016 and 31 May 2017, 17 European Union (EU) and European Economic Area countries reported 4,096 cases associated with a multi-country hepatitis A (HA) outbreak. Molecular analysis identified three co-circulating hepatitis A…
Two concurrent outbreaks of hepatitis A highlight the risk of infection for non-immune travellers to Morocco, January to June 2018 Open
From January to June 2018, two ongoing hepatitis A outbreaks affected travellers returning from Morocco and cases in Europe without travel history, resulting in 163 patients in eight European countries. Most interviewed travel-related case…
Hepatitis E virus epidemiology among HIV-infected women in an urban area in Tanzania Open
An annual HEV infection incidence rate of 1% strongly indicates ongoing transmission of HEV in Tanzania and should be kept in mind for pregnant women presenting with signs of acute hepatitis.
View article: Recommendations for enterovirus diagnostics and characterisation within and beyond Europe
Recommendations for enterovirus diagnostics and characterisation within and beyond Europe Open
Enteroviruses (EV) can cause severe neurological and respiratory infections, and occasionally lead to devastating outbreaks as previously demonstrated with EV-A71 and EV-D68 in Europe. However, these infections are still often underdiagnos…
Hepatitis A outbreak disproportionately affecting men who have sex with men (MSM) in the European Union and European Economic Area, June 2016 to May 2017 Open
Between 1 June 2016 and 31 May 2017, 17 European Union (EU) and European Economic Area countries reported 4,096 cases associated with a multi-country hepatitis A (HA) outbreak. Molecular analysis identified three co-circulating hepatitis A…