Sofie Nyström
YOU?
Author Swipe
View article: SARS-CoV-2 spike protein amyloid fibrils impair fibrin formation and fibrinolysis
SARS-CoV-2 spike protein amyloid fibrils impair fibrin formation and fibrinolysis Open
Long COVID, also known as post-acute sequelae of COVID-19 (PASC) from SARS-CoV-2 infection, is a debilitating and persistent disease of multiple systems and organs. WHO reports a total of 778 million registered SARS-CoV-2 infections as of …
View article: Efficient Seeding of Cerebral Vascular Aβ-Amyloidosis by Recombinant AβM1-42 Amyloid Fibrils
Efficient Seeding of Cerebral Vascular Aβ-Amyloidosis by Recombinant AβM1-42 Amyloid Fibrils Open
View article: Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits
Dual-ligand fluorescence microscopy enables chronological and spatial histological assignment of distinct amyloid-β deposits Open
View article: The Fluorescent Amyloid Ligand X34 Binding to Transthyretin (TTR) Tetramer and Fibrils: FRET and Binding Constants of a Sequential Two‐step Process
The Fluorescent Amyloid Ligand X34 Binding to Transthyretin (TTR) Tetramer and Fibrils: FRET and Binding Constants of a Sequential Two‐step Process Open
The amyloidogenic homotetrameric plasma protein transthyretin (TTR) has an affinity for bicyclic small molecule ligands in its two thyroxine (T4) binding sites. We have shown that native tetrameric TTR binds to amyloid ligands based on the…
View article: Divergent Age-Dependent Conformational Rearrangement within Aβ Amyloid Deposits in APP23, APPPS1, and <i>App</i> <sup> <i>NL-F</i> </sup> Mice
Divergent Age-Dependent Conformational Rearrangement within Aβ Amyloid Deposits in APP23, APPPS1, and <i>App</i> <sup> <i>NL-F</i> </sup> Mice Open
Amyloid plaques composed of fibrils of misfolded Aβ peptides are pathological hallmarks of Alzheimer's disease (AD). Aβ fibrils are polymorphic in their tertiary and quaternary molecular structures. This structural polymorphism may carry d…
View article: Efficient Seeding of Cerebral Vascular Aβ-Amyloidosis by Recombinant Aβ1-42 Amyloid Fibrils
Efficient Seeding of Cerebral Vascular Aβ-Amyloidosis by Recombinant Aβ1-42 Amyloid Fibrils Open
View article: Divergent age-dependent conformational rearrangement within Aβ amyloid deposits in APP23, APPPS1, and App<sup>NL-F</sup>mice
Divergent age-dependent conformational rearrangement within Aβ amyloid deposits in APP23, APPPS1, and App<sup>NL-F</sup>mice Open
Amyloid plaques composed of fibrils of misfolded Aβ peptides are pathological hallmarks of Alzheimer’s disease (AD). Aβ fibrils are polymorphic in their tertiary and quaternary molecular structures. This structural polymorphism may carry d…
View article: SARS-CoV-2 Spike amyloid fibrils specifically and selectively accelerates amyloid fibril formation of human prion protein and the amyloid β peptide
SARS-CoV-2 Spike amyloid fibrils specifically and selectively accelerates amyloid fibril formation of human prion protein and the amyloid β peptide Open
An increasing number of reports suggest an association between COVID-19 infection and initiation or acceleration of neurodegenerative diseases (NDs) including Alzheimer’s disease (AD) and Creutzfeldt-Jakob disease (CJD). Both these disease…
View article: Viruses and amyloids - a vicious liaison
Viruses and amyloids - a vicious liaison Open
The crosstalk between viral infections, amyloid formation and neurodegeneration has been discussed with varying intensity since the last century. Several viral proteins are known to be amyloidogenic. Post-acute sequalae (PAS) of viral infe…
View article: <i>In Vivo</i> Targeting and Multimodal Imaging of Cerebral Amyloid-β Aggregates Using Hybrid Gdf <sub>3</sub> Nanoparticles
<i>In Vivo</i> Targeting and Multimodal Imaging of Cerebral Amyloid-β Aggregates Using Hybrid Gdf <sub>3</sub> Nanoparticles Open
Aim: To propose a new multimodal imaging agent targeting amyloid-β (Aβ) plaques in Alzheimer's disease. Materials & methods: A new generation of hybrid contrast agents, based on gadolinium fluoride nanoparticles grafted with …
View article: Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosis
Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosis Open
Cerebrospinal fluid (CSF) biomarkers play an important role in diagnosing Alzheimer’s disease (AD) which is characterized by amyloid-β (Aβ) amyloidosis. Here, we used two App knock-in mouse models, App NL-F/NL-F and App NL-G-F/NL-G-F , exh…
View article: HSP10 as a Chaperone for Neurodegenerative Amyloid Fibrils
HSP10 as a Chaperone for Neurodegenerative Amyloid Fibrils Open
Neurodegenerative diseases (NDs) are associated with accumulated misfolded proteins (MPs). MPs oligomerize and form multiple forms of amyloid fibril polymorphs that dictate fibril propagation and cellular dysfunction. Protein misfolding pr…
View article: Amyloidogenesis of SARS-CoV-2 Spike Protein
Amyloidogenesis of SARS-CoV-2 Spike Protein Open
SARS-CoV-2 infection is associated with a surprising number of morbidities. Uncanny similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances together with neurologic and cardiac problems led us to invest…
View article: Additional file 1 of Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosis
Additional file 1 of Increased CSF-decorin predicts brain pathological changes driven by Alzheimer’s Aβ amyloidosis Open
Additional file 1: Table S1. Phosphorylation profiling of decorin treated and non-treated mouse primary neurons.
View article: Amyloidogenesis of SARS-CoV-2 Spike Protein
Amyloidogenesis of SARS-CoV-2 Spike Protein Open
SARS-CoV-2 infection is associated with a surprising number of morbidities. Uncanny similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances together with neurologic and cardiac problems led us to invest…
View article: Distinct conformers of amyloid beta accumulate in the neocortex of patients with rapidly progressive Alzheimer's disease
Distinct conformers of amyloid beta accumulate in the neocortex of patients with rapidly progressive Alzheimer's disease Open
View article: Tyrosine Side‐Chain Functionalities at Distinct Positions Determine the Chirooptical Properties and Supramolecular Structures of Pentameric Oligothiophenes
Tyrosine Side‐Chain Functionalities at Distinct Positions Determine the Chirooptical Properties and Supramolecular Structures of Pentameric Oligothiophenes Open
Control over the photophysical properties and molecular organization of π‐conjugated oligothiophenes is essential to their use in organic electronics. Herein we synthesized and characterized a variety of anionic pentameric oligothiophenes …
View article: Fibrillation and molecular characteristics are coherent with clinical and pathological features of 4-repeat tauopathy caused by MAPT variant G273R
Fibrillation and molecular characteristics are coherent with clinical and pathological features of 4-repeat tauopathy caused by MAPT variant G273R Open
View article: Prion protein glycans reduce intracerebral fibril formation and spongiosis in prion disease
Prion protein glycans reduce intracerebral fibril formation and spongiosis in prion disease Open
Posttranslational modifications (PTMs) are common among proteins that aggregate in neurodegenerative disease, yet how PTMs impact the aggregate conformation and disease progression remains unclear. By engineering knockin mice expressing pr…
View article: Insulin amyloid polymorphs: implications for iatrogenic cytotoxicity
Insulin amyloid polymorphs: implications for iatrogenic cytotoxicity Open
Structural polymorphism of insulin amyloids in vivo can be recognized using novel amyloid specific fluorescent probes, pFTAA and BTD21.
View article: Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer’s disease pathology
Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer’s disease pathology Open
Amyloid-β (Aβ) pathology in Alzheimer's disease (AD) is characterized by the formation of polymorphic deposits comprising diffuse and cored plaques. Because diffuse plaques are predominantly observed in cognitively unaffected, amyloid-posi…
View article: S100A9-Driven Amyloid-Neuroinflammatory Cascade in Traumatic Brain Injury as a Precursor State for Alzheimer’s Disease
S100A9-Driven Amyloid-Neuroinflammatory Cascade in Traumatic Brain Injury as a Precursor State for Alzheimer’s Disease Open
View article: Aggregated Aβ1-42 Is Selectively Toxic for Neurons, Whereas Glial Cells Produce Mature Fibrils with Low Toxicity in Drosophila
Aggregated Aβ1-42 Is Selectively Toxic for Neurons, Whereas Glial Cells Produce Mature Fibrils with Low Toxicity in Drosophila Open
View article: ApoE facilitates the microglial response to amyloid plaque pathology
ApoE facilitates the microglial response to amyloid plaque pathology Open
One of the hallmarks of Alzheimer’s disease is the presence of extracellular diffuse and fibrillar plaques predominantly consisting of the amyloid-β (Aβ) peptide. Apolipoprotein E (ApoE) influences the deposition of amyloid pathology throu…
View article: Amyloid fibril polymorphism: a challenge for molecular imaging and therapy
Amyloid fibril polymorphism: a challenge for molecular imaging and therapy Open
The accumulation of misfolded proteins ( MP s), both unique and common, for different diseases is central for many chronic degenerative diseases. In certain patients, MP accumulation is systemic (e.g. TTR amyloid), and in others, this is l…
View article: Aggregated AA1-42 is Selectively Toxic for Neurons, Whereas Glial Cells Produce Mature Fibrils with Low Toxicity in Drosophila
Aggregated AA1-42 is Selectively Toxic for Neurons, Whereas Glial Cells Produce Mature Fibrils with Low Toxicity in Drosophila Open
View article: Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease
Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease Open
Significance The clinical and pathological variability among patients with Alzheimer’s disease (AD) remains largely unexplained. Evidence is growing that this heterogeneity may be influenced by the heterogeneous molecular architecture of m…
View article: Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging
Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging Open
Proteins that deposit as amyloid in tissues throughout the body can be the cause or consequence of a large number of diseases. Among these we find neurodegenerative diseases such as Alzheimer's and Parkinson's disease afflicting primarily …
View article: Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging
Imaging Amyloid Tissues Stained with Luminescent Conjugated Oligothiophenes by Hyperspectral Confocal Microscopy and Fluorescence Lifetime Imaging Open
Proteins that deposit as amyloid in tissues throughout the body can be the cause or consequence of a large number of diseases. Among these we find neurodegenerative diseases such as Alzheimer's and Parkinson's disease afflicting primarily …
View article: <i>trans</i>-Stilbenoids with Extended Fluorescence Lifetimes for the Characterization of Amyloid Fibrils
<i>trans</i>-Stilbenoids with Extended Fluorescence Lifetimes for the Characterization of Amyloid Fibrils Open
It was previously reported that two naphthyl-based trans-stilbene probes, (E)-4-(2-(naphthalen-1-yl)vinyl)benzene-1,2-diol (1) and (E)-4-(2-(naphthalen-2-yl)vinyl)benzene-1,2-diol (3), can bind to both na…