Sofie Seghers
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View article: Pathway-selective strategies reveal specific PI3K–mTOR inhibitors as key partners in KRAS G12D-targeted therapy
Pathway-selective strategies reveal specific PI3K–mTOR inhibitors as key partners in KRAS G12D-targeted therapy Open
KRAS G12D is the most common oncogenic mutation in pancreatic ductal adenocarcinoma (PDAC), driving resistance and heterogeneity. Using robotic high-throughput drug screening with live-cell imaging, we evaluated normalized organoid growth …
View article: Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models
Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models Open
Lipid‐based nanoparticles (LNPs) are essential vehicles for mRNA vaccine delivery, with the chemistry of the ionizable lipid determining antigen expression levels and immune activation. In this study, a structure‐activity relationship (SAR…
View article: Development and validation of the Normalized Organoid Growth Rate (NOGR) metric in brightfield imaging-based assays
Development and validation of the Normalized Organoid Growth Rate (NOGR) metric in brightfield imaging-based assays Open
This study focuses on refining growth-rate-based drug response metrics for patient-derived tumor organoid screening using brightfield live-cell imaging. Traditional metrics like Normalized Growth Rate Inhibition (GR) and Normalized Drug Re…
View article: Challenges and prospects of LAG-3 inhibition in advanced gastric and gastroesophageal junction cancer: insights from the RELATIVITY-060 trial
Challenges and prospects of LAG-3 inhibition in advanced gastric and gastroesophageal junction cancer: insights from the RELATIVITY-060 trial Open
View article: Advancements in Research and Treatment Applications of Patient-Derived Tumor Organoids in Colorectal Cancer
Advancements in Research and Treatment Applications of Patient-Derived Tumor Organoids in Colorectal Cancer Open
Colorectal cancer (CRC) remains a significant health burden globally, being the second leading cause of cancer-related mortality. Despite significant therapeutic advancements, resistance to systemic antineoplastic agents remains an importa…
View article: Auranofin repurposing for lung and pancreatic cancer: low CA12 expression as a marker of sensitivity in patient-derived organoids, with potentiated efficacy by AKT inhibition
Auranofin repurposing for lung and pancreatic cancer: low CA12 expression as a marker of sensitivity in patient-derived organoids, with potentiated efficacy by AKT inhibition Open
Background This study explores the repurposing of Auranofin (AF), an anti-rheumatic drug, for treating non-small cell lung cancer (NSCLC) adenocarcinoma and pancreatic ductal adenocarcinoma (PDAC). Drug repurposing in oncology offers a cos…
View article: mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells
mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells Open
View article: Design of a Mesoscale Continuous‐Flow Route toward Lithiated Methoxyallene
Design of a Mesoscale Continuous‐Flow Route toward Lithiated Methoxyallene Open
Invited for this month′s cover is the group of Christian Stevens at Ghent University. The image shows how continuous flow chemistry can help to rapidly obtain a library of compounds. Lithiated alkoxyallenes are like chameleons turning them…
View article: Miniaturized continuous flow process design for challenging chemistry
Miniaturized continuous flow process design for challenging chemistry Open