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View article: The assessment of comorbidity awareness in patients with atrial fibrillation: acapaf study
The assessment of comorbidity awareness in patients with atrial fibrillation: acapaf study Open
Background Elderly patients (≥65y) with atrial fibrillation (AF) have on average five comorbidities. Addressing comorbidities is the first pillar in the AF-CARE model of the new 2024 European Society of Cardiology guidelines of AF manageme…
View article: Altered liver sinusoidal endothelial cells in MASLD and their evolution following lanifibranor treatment
Altered liver sinusoidal endothelial cells in MASLD and their evolution following lanifibranor treatment Open
Data on changes in liver sinusoidal endothelial cells (LSECs) in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and their response to treatment are limited. This study demonstrates that LSEC capillarisation …
View article: The dwarf & pale leaf mutation reduces chloroplast numbers, resulting in sugar depletion that inhibits leaf growth of maize seedlings
The dwarf & pale leaf mutation reduces chloroplast numbers, resulting in sugar depletion that inhibits leaf growth of maize seedlings Open
Plant growth is ultimately driven by cell division and expansion, but how these processes are regulated to mediate a wide range of genotypic variation in organ size is still poorly understood. To address this, we screened an EMS maize muta…
View article: Active site-directed probes targeting dipeptidyl peptidases 8 and 9
Active site-directed probes targeting dipeptidyl peptidases 8 and 9 Open
View article: <scp>S100A8</scp> ‐enriched microglia populate the brain of tau‐seeded and accelerated aging mice
<span>S100A8</span> ‐enriched microglia populate the brain of tau‐seeded and accelerated aging mice Open
Long considered to fluctuate between pro‐ and anti‐inflammatory states, it has now become evident that microglia occupy a variegated phenotypic landscape with relevance to aging and neurodegeneration. However, whether specific microglial s…
View article: S100A8-enriched microglia populate the brain of tau-seeded and accelerated aging mice
S100A8-enriched microglia populate the brain of tau-seeded and accelerated aging mice Open
Long considered to fluctuate between pro- and anti-inflammatory states, it has now become evident that microglia occupy a variegated phenotypic landscape with relevance to aging and neurodegeneration. However, whether specific microglial s…
View article: Neuroanatomical characterization of the Nmu-Cre knock-in mice reveals an interconnected network of unique neuropeptidergic cells
Neuroanatomical characterization of the Nmu-Cre knock-in mice reveals an interconnected network of unique neuropeptidergic cells Open
Neuromedin U (NMU) is an evolutionary conserved neuropeptide that has been implicated in multiple processes, such as circadian regulation, energy homeostasis, reward processing and stress coping. Although the central expression of NMU has …
View article: ProCPU Is Expressed by (Primary) Human Monocytes and Macrophages and Expression Differs between States of Differentiation and Activation
ProCPU Is Expressed by (Primary) Human Monocytes and Macrophages and Expression Differs between States of Differentiation and Activation Open
Carboxypeptidase U (CPU, TAFIa, CPB2) is a potent attenuator of fibrinolysis that is mainly synthesized by the liver as its inactive precursor proCPU. Aside from its antifibrinolytic properties, evidence exists that CPU can modulate inflam…
View article: Response Surface Methodology to Efficiently Optimize Intracellular Delivery by Photoporation
Response Surface Methodology to Efficiently Optimize Intracellular Delivery by Photoporation Open
Photoporation is an up-and-coming technology for the gentle and efficient transfection of cells. Inherent to the application of photoporation is the optimization of several process parameters, such as laser fluence and sensitizing particle…
View article: Neuroanatomical characterization of the Nmu-Cre knock-in mice reveals an interconnected network of unique neuropeptidergic cells
Neuroanatomical characterization of the Nmu-Cre knock-in mice reveals an interconnected network of unique neuropeptidergic cells Open
Neuromedin U (NMU) is an evolutionary conserved neuropeptide that has been implicated in multiple processes, such as circadian regulation, energy homeostasis, reward processing and stress coping. Although central expression of NMU has been…
View article: Active Site-Directed Probes Targeting Dipeptidyl Peptidases 8 and 9
Active Site-Directed Probes Targeting Dipeptidyl Peptidases 8 and 9 Open
View article: Impact of pulmonary African trypanosomes on the immunology and function of the lung
Impact of pulmonary African trypanosomes on the immunology and function of the lung Open
View article: Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation
Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation Open
Monocyte-derived macrophages (Mφs) are crucial regulators during muscularis inflammation. However, it is unclear which micro-environmental factors are responsible for monocyte recruitment and anti-inflammatory Mφ differentiation in this pa…
View article: O-155 Dietary caloric normalization or restriction as preconception care strategies: impact on oocyte developmental competence and quality in high fat/high sugar-induced obese outbred mice
O-155 Dietary caloric normalization or restriction as preconception care strategies: impact on oocyte developmental competence and quality in high fat/high sugar-induced obese outbred mice Open
Study question Can diet normalization or caloric restriction (CR) for two weeks be used as a preconception care intervention in obese Swiss mice to restore oocyte development and quality Summary answer Diet normalization or CR as short-ter…
View article: Enteric glial cells favour accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation
Enteric glial cells favour accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation Open
Objective Monocyte-derived macrophages (Mφs) are crucial regulators during muscularis inflammation. However, it is unclear which microenvironmental factors are responsible for monocyte recruitment and neurotrophic Mφ differentiation in thi…
View article: Gibberellin Enhances the Anisotropy of Cell Expansion in the Growth Zone of the Maize Leaf
Gibberellin Enhances the Anisotropy of Cell Expansion in the Growth Zone of the Maize Leaf Open
Although plant organ shapes are defined by spatio-temporal variations of directional tissue expansion, this is a little characterized aspect of organ growth regulation. Although it is well known that the plant hormone gibberellin increases…
View article: Lactobacilli Have a Niche in the Human Nose
Lactobacilli Have a Niche in the Human Nose Open
Although an increasing number of beneficial microbiome members are characterized for the human gut and vagina, beneficial microbes are underexplored for the human upper respiratory tract (URT). In this study, we demonstrate that taxa from …
View article: Comparative genome analysis of Lactobacillus mudanjiangensis, an understudied member of the Lactobacillus plantarum group
Comparative genome analysis of Lactobacillus mudanjiangensis, an understudied member of the Lactobacillus plantarum group Open
The genus Lactobacillus is known to be extremely diverse and consists of different phylogenetic groups that show a diversity that is roughly equal to the expected diversity of a typical bacterial genus. One of the most prominent phylogenet…
View article: Recombinant human collagen type I hydrogels as superior cell carriers for corneal epithelial stem cells and corneal transplantation.
Recombinant human collagen type I hydrogels as superior cell carriers for corneal epithelial stem cells and corneal transplantation. Open
View article: Impact of spray‐drying on the pili of <i>Lactobacillus rhamnosus</i> <scp>GG</scp>
Impact of spray‐drying on the pili of <i>Lactobacillus rhamnosus</i> <span>GG</span> Open
Summary The preservation of the viability of microorganisms in probiotic formulations is the most important parameter ensuring the adequate concentration of live microorganisms at the time of administration. The formulation and processing …
View article: Comparative genome analysis of<i>Lactobacillus mudanjiangensis</i>, an understudied member of the<i>Lactobacillus plantarum</i>group
Comparative genome analysis of<i>Lactobacillus mudanjiangensis</i>, an understudied member of the<i>Lactobacillus plantarum</i>group Open
The genus Lactobacillus is known to be extremely diverse and consists of different phylogenetic groups that show a diversity roughly equal to the expected diversity of a typical bacterial genus. One of the most prominent phylogenetic group…
View article: Lactobacilli Have a Niche in the Human Nose
Lactobacilli Have a Niche in the Human Nose Open
View article: Experimentally Induced Biliary Atresia by Means of Rotavirus‐Infection Is Directly Linked to Severe Damage of the Microvasculature in the Extrahepatic Bile Duct
Experimentally Induced Biliary Atresia by Means of Rotavirus‐Infection Is Directly Linked to Severe Damage of the Microvasculature in the Extrahepatic Bile Duct Open
Vascular damage has been reported to contribute to atresia formation in several diseases including biliary atresia. This study focused on the extrahepatic biliary plexus in experimental biliary atresia. Newborn BALB/cAnNCrl‐pups were infec…
View article: Selective gene expression analysis of the neuroepithelial body microenvironment in postnatal lungs with special interest for potential stem cell characteristics
Selective gene expression analysis of the neuroepithelial body microenvironment in postnatal lungs with special interest for potential stem cell characteristics Open
View article: Maternal metabolic stress may affect oviduct gatekeeper function
Maternal metabolic stress may affect oviduct gatekeeper function Open
We hypothesized that elevated non-esterified fatty acids (NEFA) modify in vitro bovine oviduct epithelial cell (BOEC) metabolism and barrier function. Hereto, BOECs were studied in a polarized system with 24-h treatments at Day 9: (1) cont…
View article: Linear viral load increase of a single HPV‐type in women with multiple HPV infections predicts progression to cervical cancer
Linear viral load increase of a single HPV‐type in women with multiple HPV infections predicts progression to cervical cancer Open
Persistent high‐risk human papillomavirus (HPV) infection is strongly associated with development of high‐grade cervical intraepithelial neoplasia or cancer (CIN3+). In single type infections, serial type‐specific viral‐load measurements p…
View article: Identification of human papillomavirus types causing lesions in penile canerous, pre-cancerous and benign lesions using laser microdissection
Identification of human papillomavirus types causing lesions in penile canerous, pre-cancerous and benign lesions using laser microdissection Open
Background: Almost half of penile cancers and the majority of penile warts are associated with the two HR types (HPV 16 and HPV 18) and two LR HPV types (HPV 6 and HPV 11), respectively. It is therefore important to document the burden HPV…
View article: In-vivo evaluation of apocynin for prevention of Helicobacter pylori-induced gastric carcinogenesis
In-vivo evaluation of apocynin for prevention of Helicobacter pylori-induced gastric carcinogenesis Open
The emergence of antibiotic-resistant Helicobacter pylori strains impacts the efficacy of eradication therapy and promotes the development of alternative treatment strategies. Apocynin inhibits neutrophil NADPH oxidase and hence may decrea…