Sofieke Temmink
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View article: Outcomes of watch and wait after short-course radiotherapy in an international multicentre watch-and-wait cohort
Outcomes of watch and wait after short-course radiotherapy in an international multicentre watch-and-wait cohort Open
View article: Surgical Outcomes after Radiotherapy in Rectal Cancer
Surgical Outcomes after Radiotherapy in Rectal Cancer Open
Over the past decade, the treatment of rectal cancer has changed considerably. The implementation of TME surgery has, in addition to decreasing the number of local recurrences, improved surgical morbidity and mortality. At the same time, t…
View article: Oncological outcomes after a pathological complete response following total neoadjuvant therapy or chemoradiotherapy for high-risk locally advanced rectal cancer in the RAPIDO trial
Oncological outcomes after a pathological complete response following total neoadjuvant therapy or chemoradiotherapy for high-risk locally advanced rectal cancer in the RAPIDO trial Open
The doubled pCR rate of TNT compared to CRT results in similar oncological outcomes. Characteristics associated with pCR are the EXP treatment, normal CEA, and small tumour size.
View article: Oncological Outcomes after a Pathological Complete Response Following Total Neoadjuvant Therapy or Chemoradiotherapy for High-Risk Locally Advanced Rectal Cancer in the RAPIDO Trial
Oncological Outcomes after a Pathological Complete Response Following Total Neoadjuvant Therapy or Chemoradiotherapy for High-Risk Locally Advanced Rectal Cancer in the RAPIDO Trial Open
View article: Complete response rates in rectal cancer: Temporal changes over a decade in a population-based nationwide cohort
Complete response rates in rectal cancer: Temporal changes over a decade in a population-based nationwide cohort Open
During the studied time period the overall complete response rate increased significantly presumably due to changes in national neoadjuvant treatment regimens. Since the start of the national WoW study clinical complete response seem to pa…
View article: Author response to: Comment on: Outcomes following watch and wait of a clinical complete response in rectal cancer after neoadjuvant treatment: comparison of patients with and without complete response at first reassessment in the International Watch & Wait Database (IWWD)
Author response to: Comment on: Outcomes following watch and wait of a clinical complete response in rectal cancer after neoadjuvant treatment: comparison of patients with and without complete response at first reassessment in the International Watch & Wait Database (IWWD) Open
View article: Baseline and early digital [18F]FDG PET/CT and multiparametric MRI contain promising features to predict response to neoadjuvant therapy in locally advanced rectal cancer patients: a pilot study
Baseline and early digital [18F]FDG PET/CT and multiparametric MRI contain promising features to predict response to neoadjuvant therapy in locally advanced rectal cancer patients: a pilot study Open
Objective In this pilot study, we investigated the feasibility of response prediction using digital [ 18 F]FDG PET/computed tomography (CT) and multiparametric MRI before, during, and after neoadjuvant chemoradiation therapy in locally adv…
View article: Watch and wait after neoadjuvant treatment in rectal cancer: comparison of outcomes in patients with and without a complete response at first reassessment in the International Watch & Wait Database (IWWD)
Watch and wait after neoadjuvant treatment in rectal cancer: comparison of outcomes in patients with and without a complete response at first reassessment in the International Watch & Wait Database (IWWD) Open
Background In rectal cancer, watch and wait for patients with a cCR after neoadjuvant treatment has an established evidence base. However, there is a lack of consensus on the definition and management of a near-cCR. This study aimed to com…
View article: Submucosal Regrowths after Watch and Wait in Rectal Cancer: A Case Series
Submucosal Regrowths after Watch and Wait in Rectal Cancer: A Case Series Open
This case series presents three patients with Stage II and III rectal cancer treated with neoadjuvant (chemo)radiotherapy who, after achieving initial complete response, developed cancer regrowths. In over 90% of cases, rectal cancer regro…
View article: Watch and wait after a clinical complete response in rectal cancer patients younger than 50 years
Watch and wait after a clinical complete response in rectal cancer patients younger than 50 years Open
Background Young-onset rectal cancer, in patients less than 50 years, is expected to increase in the coming years. A watch-and-wait strategy is nowadays increasingly practised in patients with a clinical complete response (cCR) after neoad…