Sofya A. Osharovich
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View article: Non-Small Cell Lung Cancer Imaging Using a Phospholipase A2 Activatable Fluorophore
Non-Small Cell Lung Cancer Imaging Using a Phospholipase A2 Activatable Fluorophore Open
Lung cancer, the most common cause of cancer-related death in the United States, requires advanced intraoperative detection methods to improve evaluation of surgical margins. In this study we employed DDAO-arachidonate (DDAO-A), a phosphol…
View article: Nonprotecting Group Synthesis of a Phospholipase C Activatable Probe with an Azo-Free Quencher
Nonprotecting Group Synthesis of a Phospholipase C Activatable Probe with an Azo-Free Quencher Open
The near-infrared fluorescent activatable smart probe Pyro-phosphatidylethanolamine (PtdEtn)-QSY was synthesized and observed to selectively fluoresce in the presence of phosphatidylcholine-specific phospholipase C (PC-PLC). PC-PLC is an i…