Sofya A. Polyanskaya
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View article: Data from SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia
Data from SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia Open
An enhanced requirement for nutrients is a hallmark property of cancer cells. Here, we optimized an in vivo genetic screening strategy in acute myeloid leukemia (AML), which led to the identification of the myo-inositol transporter SLC5A3 …
View article: Data from Transcriptional Silencing of <i>ALDH2</i> Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia
Data from Transcriptional Silencing of <i>ALDH2</i> Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia Open
Hundreds of genes become aberrantly silenced in acute myeloid leukemia (AML), with most of these epigenetic changes being of unknown functional consequence. Here, we demonstrate how gene silencing can lead to an acquired dependency on the …
View article: Supplementary Table S1 from Transcriptional Silencing of <i>ALDH2</i> Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia
Supplementary Table S1 from Transcriptional Silencing of <i>ALDH2</i> Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia Open
The E2/E3 sgRNA guide sequences.
View article: Supplementary Table S1 from Transcriptional Silencing of <i>ALDH2</i> Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia
Supplementary Table S1 from Transcriptional Silencing of <i>ALDH2</i> Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia Open
The E2/E3 sgRNA guide sequences.
View article: Supplementary Table S2 from Transcriptional Silencing of <i>ALDH2</i> Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia
Supplementary Table S2 from Transcriptional Silencing of <i>ALDH2</i> Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia Open
CRISPR screening data using the E2/E3 sgRNA library in 12 cell lines.
View article: Data from SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia
Data from SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia Open
An enhanced requirement for nutrients is a hallmark property of cancer cells. Here, we optimized an in vivo genetic screening strategy in acute myeloid leukemia (AML), which led to the identification of the myo-inositol transporter SLC5A3 …
View article: Supplementary Figures S1-S17 from SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia
Supplementary Figures S1-S17 from SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia Open
Figures S1 to S17
View article: Supplementary Table 2 from SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia
Supplementary Table 2 from SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia Open
Supplementary Table 2
View article: Supplementary Table 1 from SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia
Supplementary Table 1 from SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia Open
Supplementary Table 1
View article: Supplementary Table S3 from Transcriptional Silencing of <i>ALDH2</i> Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia
Supplementary Table S3 from Transcriptional Silencing of <i>ALDH2</i> Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia Open
Sequences of additional sgRNA and primers.
View article: Supplementary Material from Transcriptional Silencing of <i>ALDH2</i> Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia
Supplementary Material from Transcriptional Silencing of <i>ALDH2</i> Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia Open
Supplementary Figures
View article: Supplementary Table S2 from Transcriptional Silencing of <i>ALDH2</i> Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia
Supplementary Table S2 from Transcriptional Silencing of <i>ALDH2</i> Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia Open
CRISPR screening data using the E2/E3 sgRNA library in 12 cell lines.
View article: Supplementary Table S3 from Transcriptional Silencing of <i>ALDH2</i> Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia
Supplementary Table S3 from Transcriptional Silencing of <i>ALDH2</i> Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia Open
Sequences of additional sgRNA and primers.
View article: Supplementary Table 2 from SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia
Supplementary Table 2 from SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia Open
Supplementary Table 2
View article: Supplementary Table 1 from SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia
Supplementary Table 1 from SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia Open
Supplementary Table 1
View article: Data from Transcriptional Silencing of <i>ALDH2</i> Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia
Data from Transcriptional Silencing of <i>ALDH2</i> Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia Open
Hundreds of genes become aberrantly silenced in acute myeloid leukemia (AML), with most of these epigenetic changes being of unknown functional consequence. Here, we demonstrate how gene silencing can lead to an acquired dependency on the …
View article: Supplementary Material from Transcriptional Silencing of <i>ALDH2</i> Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia
Supplementary Material from Transcriptional Silencing of <i>ALDH2</i> Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia Open
Supplementary Figures
View article: Supplementary Figures S1-S17 from SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia
Supplementary Figures S1-S17 from SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia Open
Figures S1 to S17
View article: The SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
The SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia Open
Summary Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we used domain-focused CRISPR screening to identify the nuclear phosphatase SCP4 as a dependency in AML, yet thi…
View article: Transcriptional Silencing of <i>ALDH2</i> Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia
Transcriptional Silencing of <i>ALDH2</i> Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia Open
Hundreds of genes become aberrantly silenced in acute myeloid leukemia (AML), with most of these epigenetic changes being of unknown functional consequence. Here, we demonstrate how gene silencing can lead to an acquired dependency on the …
View article: <i>In vivo</i>genetic screen identifies a SLC5A3-dependent myo-inositol auxotrophy in acute myeloid leukemia
<i>In vivo</i>genetic screen identifies a SLC5A3-dependent myo-inositol auxotrophy in acute myeloid leukemia Open
An enhanced requirement for extracellular nutrients is a hallmark property of cancer cells. Here, we optimized an in vivo genetic screening strategy for evaluating dependencies in acute myeloid leukemia (AML), which led to the identificati…
View article: A Nuclear Phosphatase-Kinase Signaling Complex That Supports Acute Myeloid Leukemia
A Nuclear Phosphatase-Kinase Signaling Complex That Supports Acute Myeloid Leukemia Open
Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. A tightly regulated balance between phosphorylation and dephosphorylation, sustained by coordinated and competing activities o…
View article: Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo
Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo Open
Transcription factors are important drivers in acute myeloid leukemia (AML), but they are notoriously difficult to target. The authors demonstrate that inhibition of salt-inducible kinase (SIK3) inhibits AML cell proliferation in cells dep…
View article: Sliding of a 43S ribosomal complex from the recognized AUG codon triggered by a delay in eIF2-bound GTP hydrolysis
Sliding of a 43S ribosomal complex from the recognized AUG codon triggered by a delay in eIF2-bound GTP hydrolysis Open
During eukaryotic translation initiation, 43S ribosomal complex scans mRNA leader unless an AUG codon in an appropriate context is found. Establishing the stable codon-anticodon base-pairing traps the ribosome on the initiator codon and tr…