Sofya Mikhaleva
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View article: Adaptation of <i>Enterococcus faecalis</i> to intestinal mucus revealed by a human colonic organoid model
Adaptation of <i>Enterococcus faecalis</i> to intestinal mucus revealed by a human colonic organoid model Open
The human gastrointestinal tract hosts a diverse population of microorganisms that have a significant impact on host health. Among this population, Enterococcus faecalis ( Ef ) represents a common member of intestinal microbiota colonizing…
View article: Visualizing the disordered nuclear transport machinery in situ
Visualizing the disordered nuclear transport machinery in situ Open
The approximately 120 MDa mammalian nuclear pore complex (NPC) acts as a gatekeeper for the transport between the nucleus and cytosol 1 . The central channel of the NPC is filled with hundreds of intrinsically disordered proteins (IDPs) ca…
View article: Deciphering the conformations and dynamics of FG-nucleoporins <i>in situ</i>
Deciphering the conformations and dynamics of FG-nucleoporins <i>in situ</i> Open
The ∼120 MDa nuclear pore complex (NPC) acts as a gatekeeper for the molecular traffic between the nucleus and the cytosol. Small cargo readily passes through the transport channel, yet large cargo requires specialized nuclear transport re…
View article: Cover Picture: Debugging Eukaryotic Genetic Code Expansion for Site‐Specific Click‐PAINT Super‐Resolution Microscopy (Angew. Chem. Int. Ed. 52/2016)
Cover Picture: Debugging Eukaryotic Genetic Code Expansion for Site‐Specific Click‐PAINT Super‐Resolution Microscopy (Angew. Chem. Int. Ed. 52/2016) Open
Cytoplasmic re-targeting of the pyrrolysine-based genetic code expansion machinery by using a nuclear export signal (NES) substantially increases the site-specific incorporation of clickable amino acids (green) into proteins in mammalian c…
View article: Debugging Eukaryotic Genetic Code Expansion for Site‐Specific Click‐PAINT Super‐Resolution Microscopy
Debugging Eukaryotic Genetic Code Expansion for Site‐Specific Click‐PAINT Super‐Resolution Microscopy Open
Super‐resolution microscopy (SRM) greatly benefits from the ability to install small photostable fluorescent labels into proteins. Genetic code expansion (GCE) technology addresses this demand, allowing the introduction of small labeling s…