Sofya Norman
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Non-invasive in vivo bidirectional magnetogenetic modulation of pain circuits Open
Primary nociceptors in the dorsal root ganglion (DRG) receive sensory information from discrete parts of the body and are responsible for initiating signaling events that in supraspinal regions will be interpreted as physiological or patho…
View article: Bidirectional regulation of motor circuits using magnetogenetic gene therapy
Bidirectional regulation of motor circuits using magnetogenetic gene therapy Open
Here, we report a magnetogenetic system, based on a single anti-ferritin nanobody-TRPV1 receptor fusion protein, which regulated neuronal activity when exposed to magnetic fields. Adeno-associated virus (AAV)–mediated delivery of a floxed …
Bidirectional Regulation of Motor Circuits Using Magnetogenetic Gene Therapy Open
Here we report a novel suite of magnetogenetic tools, based on a single anti-ferritin nanobody-TRPV1 receptor fusion protein, which regulated neuronal activity when exposed to magnetic fields. AAV-mediated delivery of a floxed nanobody-TRP…
Management of refractory bacterial meningitis–associated cerebral vasospasm: illustrative case Open
BACKGROUND Cerebral vasospasm is an alarming complication of acute bacterial meningitis with potentially devastating consequences. It is essential for providers to recognize and treat it appropriately. Unfortunately, there is no well-estab…
COVD-27. THE COVID-19 PANDEMIC AND NEURO-ONCOLOGICAL PATIENTS Open
INTRODUCTION The Coronavirus disease 2019 (COVID-19) pandemic has uprooted healthcare systems worldwide, disrupting care and increasing dependence on alternative forms of health care delivery. It is yet to be determined how the pandemic af…
A Retrospective Analysis of Precision Medicine Outcomes in Patients With Advanced Cancer Reveals Improved Progression-Free Survival Without Increased Health Care Costs Open
Purpose: The advent of genomic diagnostic technologies such as next-generation sequencing has recently enabled the use of genomic information to guide targeted treatment in patients with cancer, an approach known as precision medicine. How…