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View article: Zika Virus: Epidemiology, Clinical Manifestations, and Public Health Implications
Zika Virus: Epidemiology, Clinical Manifestations, and Public Health Implications Open
The Zika virus (ZIKV), a member of the Flavivirus genus, has garnered significant attention since its discovery in 1947, primarily due to its association with neurological complications and congenital anomalies. This abstract synthesises k…
View article: COMPARISON BETWEEN LATHE-CUT AND CAST-MOLDING SOFT CONTACT LENS MANUFACTURING TECHNIQUES ON OCULAR SURFACE INTEGRITY: A DOUBLE-BLIND RANDOMIZED CONTROL TRIAL
COMPARISON BETWEEN LATHE-CUT AND CAST-MOLDING SOFT CONTACT LENS MANUFACTURING TECHNIQUES ON OCULAR SURFACE INTEGRITY: A DOUBLE-BLIND RANDOMIZED CONTROL TRIAL Open
Background:Soft contact lenses are widely used for vision correction due to their comfort and optical performance. The manufacturing technique—whether lathe-cut or cast-molded—can significantly affect lens properties, including surface smo…
View article: Staphylococcus epidermidis in Acute Myeloid Leukemia: A Comparative Genomic Study Against Non-AML Isolates
Staphylococcus epidermidis in Acute Myeloid Leukemia: A Comparative Genomic Study Against Non-AML Isolates Open
Bloodstream infections (BSIs) are a major cause of morbidity and mortality in acute myeloid leukemia (AML) patients undergoing induction chemotherapy. Staphylococcus epidermidis, typically a skin commensal, is increasingly recognized as a …
View article: Effect of Corneal vs Scleral Rigid Gas Permeable (RGP) Lenses on corneal curvature and thickness in patients of Keratoconus
Effect of Corneal vs Scleral Rigid Gas Permeable (RGP) Lenses on corneal curvature and thickness in patients of Keratoconus Open
Objective: To investigate the changes in corneal curvature and thickness in patients of Keratoconus, wearing Rose k2 corneal and XL (scleral lenses) from last three months. Methodology: Interventional study was conducted at The Keratoconus…
View article: GLYCOSYLATED HEMOGLOBIN HBA1C AS A BIOMARKER FOR DIABETIC RETINOPATHY
GLYCOSYLATED HEMOGLOBIN HBA1C AS A BIOMARKER FOR DIABETIC RETINOPATHY Open
: Diabetes Mellitus (DM) is a long-term metabolic disorder marked by hyperglycemia. Diabetes may lead to various complications like retinopathy. Diabetic retinopathy is a microvascular disorder that may lead to vision loss. It was a hospit…
View article: PREVALENCE AND ANTIBIOTIC SUSCEPTIBILITY PATTERN OF HELICOBACTER PYLORI ISOLATES FROM GASTRIC BIOPSIES OF PATIENTS IN TERTIARY CARE HOSPITAL
PREVALENCE AND ANTIBIOTIC SUSCEPTIBILITY PATTERN OF HELICOBACTER PYLORI ISOLATES FROM GASTRIC BIOPSIES OF PATIENTS IN TERTIARY CARE HOSPITAL Open
Worldwide, Helicobacter pylori is prevalent and is strongly associated with causing numerous digestive tract infections. Combination therapy for this pathogen includes a combination of antimicrobials such as amoxicillin, metronidazole, cla…
View article: Supplememtary Methods, Figures 1 - 4, Tables 1 - 3 from ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy
Supplememtary Methods, Figures 1 - 4, Tables 1 - 3 from ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy Open
Supplementary Material and Methods : Plasma pharmacokinetics of topotecan with and without the ABCG2 inhibitor Ko143. Supplementary Figure S1: RNA expression of ABC transporters in human and mouse Group3 medulloblastoma. Supplementary Figu…
View article: Supplememtary Methods, Figures 1 - 4, Tables 1 - 3 from ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy
Supplememtary Methods, Figures 1 - 4, Tables 1 - 3 from ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy Open
Supplementary Material and Methods : Plasma pharmacokinetics of topotecan with and without the ABCG2 inhibitor Ko143. Supplementary Figure S1: RNA expression of ABC transporters in human and mouse Group3 medulloblastoma. Supplementary Figu…
View article: Data from ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy
Data from ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy Open
While a small number of plasma membrane ABC transporters can export chemotherapeutic drugs and confer drug resistance, it is unknown whether these transporters are expressed or functional in less therapeutically tractable cancers such as G…
View article: Data from ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy
Data from ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy Open
While a small number of plasma membrane ABC transporters can export chemotherapeutic drugs and confer drug resistance, it is unknown whether these transporters are expressed or functional in less therapeutically tractable cancers such as G…
View article: 3’ UTR-truncated HMGA2 overexpression induces non-malignant in vivo expansion of hematopoietic stem cells in non-human primates
3’ UTR-truncated HMGA2 overexpression induces non-malignant in vivo expansion of hematopoietic stem cells in non-human primates Open
Vector-mediated mutagenesis remains a major safety concern for many gene therapy clinical protocols. Indeed, lentiviral-based gene therapy treatments of hematologic disease can result in oligoclonal blood reconstitution in the transduced c…
View article: Marking of definitive HSC precursors in E7.5–E8.5 embryos using an Abcg2-CreER lineage-tracing mouse model
Marking of definitive HSC precursors in E7.5–E8.5 embryos using an Abcg2-CreER lineage-tracing mouse model Open
Abcg2, a member of the ATP-binding cassette transporter family, is expressed in adult hematopoietic stem cells (HSCs) and is required for the side population phenotype of adult bone marrow HSCs and other adult tissue-specific stem cells. L…
View article: Evaluating the Safety of Retroviral Vectors Based on Insertional Oncogene Activation and Blocked Differentiation in Cultured Thymocytes
Evaluating the Safety of Retroviral Vectors Based on Insertional Oncogene Activation and Blocked Differentiation in Cultured Thymocytes Open
Insertional oncogenesis due to retroviral (RV) vector integration has caused recurrent leukemia in multiple gene therapy trials, predominantly due to vector integration effects at the LMO2 locus. While currently available preclinical safet…