Soh Yamamoto
YOU?
Author Swipe
View article: Bacillaceae serine proteases and Streptomyces epsilon-poly-l-lysine synergistically inactivate Caliciviridae by inhibiting RNA genome release
Bacillaceae serine proteases and Streptomyces epsilon-poly-l-lysine synergistically inactivate Caliciviridae by inhibiting RNA genome release Open
Human norovirus (HuNoV) is an enteric infectious pathogen belonging to the Caliciviridae family that causes occasional epidemics. Circulating alcohol-tolerant viral particles that are readily transmitted via food-borne routes significantly…
View article: Multilayered proteomics reveals that <scp>JAM</scp>‐A promotes breast cancer progression via regulation of amino acid transporter <scp>LAT1</scp>
Multilayered proteomics reveals that <span>JAM</span>‐A promotes breast cancer progression via regulation of amino acid transporter <span>LAT1</span> Open
Recent studies have shown that transmembrane‐type tight junction proteins are upregulated in various cancers compared with their levels in normal tissues and are involved in cancer progression, suggesting that they are potential therapeuti…
View article: The clarithromycin-binding proteins NIPSNAP1 and 2 regulate cytokine production through mitochondrial quality control
The clarithromycin-binding proteins NIPSNAP1 and 2 regulate cytokine production through mitochondrial quality control Open
The mechanism underlying the anti-inflammatory effect of macrolide antibiotics, such as clarithromycin (CAM), remains to be clarified. The CAM-binding proteins 4-nitrophenylphosphatase domain and non-neuronal synaptosomal associated protei…
View article: Rapid evolution bacteria reveal pathogenic mechanisms and clinical risk
Rapid evolution bacteria reveal pathogenic mechanisms and clinical risk Open
Bacteria continually evolve, as postulated in Darwin’s theory of evolution1-3. Previous studies have evaluated bacterial evolution in retrospect, but this approach is based on only speculation4-6. Cohort studies are reliable but require a …
View article: Serotype replacement and an increase in non-encapsulated isolates among community-acquired infections of Streptococcus pneumoniae during post-vaccine era in Japan
Serotype replacement and an increase in non-encapsulated isolates among community-acquired infections of Streptococcus pneumoniae during post-vaccine era in Japan Open
The progression of serotype replacement in non-invasive pneumococcal infections has occurred during the post-vaccine era in Japan, and non-encapsulated isolates, such as NCC, have increased. Antimicrobial susceptibility is not worsened.
View article: High prevalence of colistin heteroresistance in specific species and lineages of Enterobacter cloacae complex derived from human clinical specimens
High prevalence of colistin heteroresistance in specific species and lineages of Enterobacter cloacae complex derived from human clinical specimens Open
Background Colistin (CST) is a last-line drug for multidrug-resistant Gram-negative bacterial infections. CST-heteroresistant Enterobacter cloacae complex (ECC) has been isolated. However, integrated analysis of epidemiology and resistance…
View article: The potent BECN2-ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation of GPRASP1/GASP1-associated GPCRs
The potent BECN2-ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation of GPRASP1/GASP1-associated GPCRs Open
AMBRA1 autophagy and beclin 1 regulator 1; ATG14 autophagy related 14; ATG5 autophagy related 5; ATG7 autophagy related 7; BECN1 beclin 1; BECN2 beclin 2; CC coiled-coil; CQ chloroquine CNR1/CB1R cannabinoid receptor 1 DAPI 4',6-diamidino-…
View article: Colistin-resistant bacteria poses few risks under physiological conditions
Colistin-resistant bacteria poses few risks under physiological conditions Open
Globally, 5.0 million people die annually from infections associated with antimicrobial-resistant bacteria, most commonly Escherichia coli1. As colistin is a last-resort antibiotic for multidrug-resistant bacterial infections, the global s…
View article: High prevalence of colistin heteroresistance in specific species and lineages of Enterobacter cloacae complex derived from human clinical specimens
High prevalence of colistin heteroresistance in specific species and lineages of Enterobacter cloacae complex derived from human clinical specimens Open
Background Colistin (CST) is a last-line drug for multidrug-resistant Gram-negative bacterial infections. CST-heteroresistant Enterobacter cloacae complex (ECC) has been isolated. However, integrated analysis of epidemiology and resistance…
View article: Additional file 1 of High prevalence of colistin heteroresistance in specific species and lineages of Enterobacter cloacae complex derived from human clinical specimens
Additional file 1 of High prevalence of colistin heteroresistance in specific species and lineages of Enterobacter cloacae complex derived from human clinical specimens Open
Additional file 1: Table S1. Sequences of primers used in this study. Table S2. Characteristics of ECC and K. aerogenes clinical isolates used in this study. Table S3. Characteristics of CST-heteroresisatnt ECC clinical isolates. Table S4.…
View article: Reduction of susceptibility to azoles and 5-fluorocytosine and growth acceleration in <i>Candida albicans</i> by glucose in urine
Reduction of susceptibility to azoles and 5-fluorocytosine and growth acceleration in <i>Candida albicans</i> by glucose in urine Open
Candida species are causal pathogens for urinary tract infections, vulvovaginitis, and balanitis. Diabetes mellitus is a risk factor for Candida infection. To investigate the potential effects of glucosuria on Candida spp. ( C. albicans, C…
View article: An autophagy-related protein Becn2 regulates cocaine reward behaviors in the dopaminergic system
An autophagy-related protein Becn2 regulates cocaine reward behaviors in the dopaminergic system Open
The addictive effects of cocaine are regulated by an autophagy protein and can be prevented by autophagy inhibitors.
View article: Aberrant expression of junctional adhesion molecule‐A contributes to the malignancy of cervical adenocarcinoma by interaction with poliovirus receptor/CD155
Aberrant expression of junctional adhesion molecule‐A contributes to the malignancy of cervical adenocarcinoma by interaction with poliovirus receptor/CD155 Open
Recent studies have shown that aberrant expression of tight junction proteins (TJP) contributes to malignant potential of various cancers. In the present study, we investigated the expression of junctional adhesion molecule‐A (JAM‐A), one …
View article: Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity
Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity Open
Autophagy, a stress-induced lysosomal degradative pathway, has been assumed to exert similar metabolic effects in different organs. Here, we establish a model where autophagy plays different roles in insulin-producing β cells versus insuli…
View article: Evaluation of consistency in quantification of gene copy number by real‐time reverse transcription quantitative polymerase chain reaction and virus titer by plaque‐forming assay for human respiratory syncytial virus
Evaluation of consistency in quantification of gene copy number by real‐time reverse transcription quantitative polymerase chain reaction and virus titer by plaque‐forming assay for human respiratory syncytial virus Open
The plaque‐forming assay is the standard technique for determining viral titer, and a critical measurement for investigating viral replication. However, this assay is highly dependent on experimental technique and conditions. In the case o…
View article: A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease
A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease Open
Impairment of the autophagy pathway has been observed during the pathogenesis of Alzheimer's disease (AD), a neurodegenerative disorder characterized by abnormal deposition of extracellular and intracellular amyloid β (Aβ) peptides. Yet th…
View article: Mechanism of Reduced Susceptibility to Fosfomycin in<i>Escherichia coli</i>Clinical Isolates
Mechanism of Reduced Susceptibility to Fosfomycin in<i>Escherichia coli</i>Clinical Isolates Open
In recent years, multidrug resistance of Escherichia coli has become a serious problem. However, resistance to fosfomycin (FOM) has been low. We screened E. coli clinical isolates with reduced susceptibility to FOM and characterized molecu…
View article: Mitochondrial proteins NIP-SNAP-1 and -2 are a target for the immunomodulatory activity of clarithromycin, which involves NF-κB-mediated cytokine production
Mitochondrial proteins NIP-SNAP-1 and -2 are a target for the immunomodulatory activity of clarithromycin, which involves NF-κB-mediated cytokine production Open
Macrolide antibiotics have immunomodulatory activities, including suppression of cytokine production, cell adhesion molecule expression, and mucin production. These immunomodulatory activities improve the symptoms of respiratory diseases a…
View article: Tigecycline Nonsusceptibility Occurs Exclusively in Fluoroquinolone-Resistant Escherichia coli Clinical Isolates, Including the Major Multidrug-Resistant Lineages O25b:H4-ST131-H <i>30</i> R and O1-ST648
Tigecycline Nonsusceptibility Occurs Exclusively in Fluoroquinolone-Resistant Escherichia coli Clinical Isolates, Including the Major Multidrug-Resistant Lineages O25b:H4-ST131-H <i>30</i> R and O1-ST648 Open
Tigecycline (TGC) is a last-line drug for multidrug-resistant Enterobacteriaceae . We investigated the mechanism(s) underlying TGC nonsusceptibility (TGC resistant/intermediate) in Escherichia coli clinical isolates. The MIC of TGC was det…
View article: Pathogenic Lineage of <i>mcr</i>-Negative Colistin-Resistant <i>Escherichia coli</i>, Japan, 2008–2015
Pathogenic Lineage of <i>mcr</i>-Negative Colistin-Resistant <i>Escherichia coli</i>, Japan, 2008–2015 Open
LETTERSevolutionarily distinct from other AIVs (5).This H5N5 strain is a contemporary reassortant virus related to North American and Eurasian strains.The positive animals we identified originated from a single location on the Antarctic Pe…
View article: Mumps Virus Induces Protein-Kinase-R-Dependent Stress Granules, Partly Suppressing Type III Interferon Production
Mumps Virus Induces Protein-Kinase-R-Dependent Stress Granules, Partly Suppressing Type III Interferon Production Open
Stress granules (SGs) are cytoplasmic granular aggregations that are induced by cellular stress, including viral infection. SGs have opposing antiviral and proviral roles, which depend on virus species. The exact function of SGs during vir…